“…2,[6][7][8][9] In general, the incidence of vomiting is decreased with higher doses and IV administration of hydromorphone, with concurrent administration of acepromazine, and in purpose-bred or research conditioned dogs from which food had not been withheld versus clinical patients undergoing elective surgery. [10][11][12][13][14] Underlying gastrointestinal tract dysfunction, along with upper airway abnormalities and surgical intervention, put dogs of brachycephalic breeds at increased risk of perianesthesia vomiting, regurgitation, aspiration pneumonia, and increased mortality rate. Vomiting and regurgitation, especially when associated with anesthesia and the use of hydromorphone, have been documented as risk factors for the development of aspiration pneumonia in dogs.…”