Potential role of green tea catechins in various disease therapies: Progress and promise

Mak, Judith C.W.

doi:10.1111/j.1440-1681.2012.05673.x

Cited by 129 publications

(77 citation statements)

References 81 publications

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“…Green tea catechins are receiving increasing attention for their potential palliative properties in lowering the risk of cardiovascular disease (Chacko et al, 2010) and as potential therapeutic intervention in cardiovascular diseases (Wolfram, 2007;Babu and Liu, 2008;Mak, 2012). Here, we report a novel mechanism of action for EGCG, the major catechin of green tea: EGCG modulates the function of Ca 2ϩ handling proteins in cardiac muscle, RyR2 Ca 2ϩ release channels, and NCX.…”

Section: Discussionmentioning

confidence: 99%

Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

et al. 2012

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Green tea polyphenolic catechins exhibit biological activity in a wide variety of cell types. Although reports in the lay and scientific literature suggest therapeutic potential for improving cardiovascular health, the underlying molecular mechanisms of action remain unclear. Previous studies have implicated a wide range of molecular targets in cardiac muscle for the major green tea catechin, (Ϫ)-epigallocatechin-3-gallate (EGCG), but effects were observed only at micromolar concentrations of unclear clinical relevance. Here, we report that nanomolar concentrations of EGCG significantly enhance contractility of intact murine myocytes by increasing electrically evoked Ca 2ϩ transients, sarcoplasmic reticulum (SR) Ca 2ϩ content, and ryanodine receptor type 2 (RyR2) channel open probability. Voltageclamp experiments demonstrate that 10 nM EGCG significantly inhibits the Na ϩ -Ca 2ϩ exchanger. Of importance, other Na ϩ and Ca 2ϩ handling proteins such as Ca 2ϩ -ATPase, Na ϩ -H ϩ exchanger, and Na ϩ -K ϩ -ATPase were not affected by EGCG Յ1 M. Thus, nanomolar EGCG increases contractility in intact myocytes by coordinately modulating SR Ca 2ϩ loading, RyR2-mediated Ca 2ϩ release, and Na ϩ -Ca 2ϩ exchange. Inhibition of Na ϩ -K ϩ -ATPase activity probably contributes to the positive inotropic effects observed at EGCG concentrations Ͼ1 M. These newly recognized actions of nanomolar and micromolar EGCG should be considered when the therapeutic and toxicological potential of green tea supplementation is evaluated and may provide a novel therapeutic strategy for improving contractile function in heart failure.

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Section: Discussionmentioning

confidence: 99%

Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

et al. 2012

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“…Despite the information regarding the effects of GT and GT polyphenols on several neurodegenerative disorders (reviewed in (Mak, 2012;Mandel et al, 2006), there is little information in literature about the use of GT to treat hemorrhagic stroke. In this study, using a collagenase model of ICH in rats, we show that GT treatment attenuates neuromotor deficit and striatum oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Catechins, a group of flavonoids, constitute around 30-45% of the solid GT extract (reviewed in (Mak, 2012)). The beneficial effects of tea consumption are probably due to its bioactive components (catechins and their derivatives), demonstrated to act directly as radical scavengers and to exert indirect antioxidant effects through activation of transcription factors and phase II antioxidant defense, thus modulating the cellular redox state (see review: Mandel et al, (2006).…”

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confidence: 99%

Green Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in Rats

Souza

Altermann

Martins

et al. 2016

Neuroscience International

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The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg ) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our results show that ICH causes neuromotor deficits observed by Neurological Deficit Scale (NDS), Open Field (OF) and Rotarod (RR). GT treatment attenuates this deficit on day 3 for NDS and OF and on day 7 for RR. Also, ICH increases Reactive Oxygen Species (ROS) production and lipid peroxidation, what is not observed in ICH + GT group. Currently, there are no effective pharmacologic or non-pharmacologic neuroprotective treatments for ICH. Nutritional interventions that help on its outcome are important, since they are generally accessible and have few side effects.

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“…(+)-Catechin [(+)-C, Figure 1A], which is one of the major active components of green tea and edible plants [1] , displays the strongest antioxidant activity during human low-density lipoprotein (LDL) oxidation compared with other polyphenols [2] . It has been reported that the cytoprotective activity of catechins is mainly due to their radical-scavenging properties and iron-chelating effects in vivo [3] .…”

Section: Introductionmentioning

confidence: 99%

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms

Lin

Wang

et al. 2016

Acta Pharmacol Sin

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Aim: (+)-Catechin and puerarin are polyphenol and flavonoid, respectively, in green tea and foodstuffs. They exhibit potent antioxidant activity and are widely used for treating cardiocerebrovascular diseases. The aim of this work was to investigate the potential interactions between (+)-catechin and puerarin following concurrent oral administration in rats, and their absorption mechanisms in Caco-2 cell monolayers. Methods: Pharmacokinetic studies were conducted in male rats received (+)-catechin (140 mg/kg, po) and/or puerarin (200 mg/kg, po). The cell uptake and transport behavior in Caco-2 cell monolayers and the interactions of the two compounds were analyzed. Results: When (+)-catechin and puerarin were administered concurrently, the AUC 0-12 h and C max values of puerarin were 2.48-fold and 3.91-fold, respectively, as large as those of puerarin alone; the AUC 0-12 h and C max values of (+)-catechin were decreased to 57.62% and 77.55%, respectively, compared with those of (+)-catechin alone. In Caco-2 cell monolayers, (+)-catechin (300 and 600 μmol/L) significantly increased the cell uptake and transport of puerarin, whereas puerarin (300 and 600 μmol/L) significantly decreased the cellular uptake and transport of (+)-catechin. Furthermore, both cyclosporine A (P-glycoprotein inhibitor) and MK-571 (MRP-2 inhibitor) significantly increased the cellular uptake and transport of (+)-catechin and puerarin. Conclusion: Concurrent oral administration of (+)-catechin and puerarin significantly increased the absolute oral bioavailability of puerarin, but decreasing that of (+)-catechin. The competitive efflux of (+)-catechin and puerarin by P-glycoprotein and MRP-2 might lead to this interaction during their absorption process in the small intestine.

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Potential role of green tea catechins in various disease therapies: Progress and promise

Cited by 129 publications

References 81 publications

Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

Coordinated Regulation of Murine Cardiomyocyte Contractility by Nanomolar (−)-Epigallocatechin-3-Gallate, the Major Green Tea Catechin

Green Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in Rats

Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms

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