Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis

Jin, Yan; Qiang, Sheng; Shen, Xiaoran; Zhang, Yifeng; Liu, Bingtuan; Zhang, Guoxin

doi:10.1155/2017/1875843

Cited by 11 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A metaanalysis conducted by Yan et al suggested that miR-375 profiling can be used as a screening test for cancers if the specific race and cancer is considered. 27 Additionally, our study results revealed a significant up-regulation in FD-T2DM compared with FD-NGT group. Previous studies conducted on familial aggregation of T2DM showed a higher risk of developing diabetes and pre-diabetes progression in first degree relatives.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Baohua

et al. 2021

DMSO

View full text Add to dashboard Cite

The pancreatic islet specific microRNA-375 (miR-375) is overexpressed in type 2 diabetes mellitus (T2DM) patients suppressing the glucose-induced insulin secretion. Thus, miR-375 may serve as a biomarker for the early prediction of T2DM among high-risk individuals. We conducted this clinical study to assess the significance of miR-375 among type 2 diabetes mellitus (T2DM) patients and their first-degree relatives. Patients and Methods: We included 56 Han Chinese individuals (N: NGT = 21, T2DM = 10, FD-NGT =13 and FD-T2DM = 12) who received medical health check-ups from January 2018 to September 2018 at The Third Hospital of Yunnan Province, China. They were categorized as normal glucose tolerance (NGT), T2DM, first-degree relatives with normal glucose tolerance (FD-NGT) and first-degree relatives with T2DM (FD-T2DM). OGTT, C-peptide and Insulin tests were performed to confirm the diagnosis. The miR-375 levels were determined by Quantitative real-time RT-PCR (qRT-PCR). Results: The OGTT test showed a significant difference in T2DM and FD-T2DM groups compared with NGT and FD-NGT (p< 0.05). Similar results were observed during C-peptide and insulin tests. Interestingly, the 2-hour insulin test showed FD-NGT group having a significantly higher mean ± standard error of (64.240 ± 12.775) compared to NGT (28.836 ± 10.875). Assessment of miR-375 expression levels in 4 groups showed a significant up-regulation in T2DM and FD-T2DM compared with NGT and FD-NGT groups. A slight increase in miRNA expression was observed in FD-NGT compared with NGT group but was not statistically significant. Conclusion:The OGTT, C-peptide and insulin tests revealed a statistically significant difference in T2DM and FD-T2DM compared with NGT and FD-NGT groups. A significantly higher miR-375 expression was also observed in T2DM and FD-T2DM groups compared with NGT and FD-NGT and thus, miR-375 may serve as a stable biomarker for the early prediction of T2DM among high-risk individuals.

show abstract

Section: Discussionsupporting

confidence: 52%

“…A meta-analysis conducted by Yan et al suggested that miR-375 profiling can be used as a screening test for cancers if the specific race and cancer is considered. 27 …”

Section: Discussionmentioning

confidence: 99%

Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Baohua

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…The other common miRNAs such as mir-1269a and b, mir-210-5p, mir-147b, mir-3662-5p, mir-19a-5p and mir-4746-5p suggests that although these miRNAs does not regulate a very large set of genes and pathways, it does have a significant role in the development of cancer as it was seen regulating the most common pathways alongside the highly interactive ones. The up-regulation of the miR-1269a and miR-1269b promotes growth and inhibits apoptosis [41][42][43][44] whereas mir-210-5p over-expression results in an increase of generation of ROS and closely regulates VEGFR gene, Bcl2 which in turn regulates hypoxia and apoptosis in breast and gastric cancer patients [45][46][47][48] . A meta-analysis conducted by Li et al and other similar studies showed the prognostic factor of mir-210 in breast cancer, thereby identifying its therapeutic usage 49,50 .…”

Section: Identification Of Common Mirnas Among Different Cancer Typesmentioning

confidence: 99%

Common and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression

Niveditha

Jasoria

Narayan

et al. 2020

Sci Rep

View full text Add to dashboard Cite

cancer is a complex disease with a fatal outcome. early detection of cancer, by monitoring appropriate molecular markers is very important for its therapeutic management. in this regard, the short noncoding RnA molecules, microRnAs (miRnAs) have shown great promise due to their availability in circulating fluids facilitating non-invasive detection of cancer. In this study, an in silico comparative analysis was performed to identify specific signature miRNAs dysregulated across multiple carcinomas and simultaneously identify unique miRnAs for each cancer type as well. the miRnA-seq data of cancer patient was obtained from GDC portal and their differential expressions along with the pathways regulated by both common and unique miRnAs were analyzed. our studies show twelve miRnAs commonly dysregulated across seven different cancer types. Interestingly, four of those miRNAs (hsa-mir-210, hsa-mir-19a, hsa-mir-7 and hsa-mir-3662) are already reported as circulatory miRNAs (circRNAs); while, the miR-183 cluster along with hsa-mir-93 have been found to be incorporated in exosomes signifying the importance of the identified miRNAs for their use as prospective, non-invasive biomarkers. further, the target mRnAs and pathways regulated by both common and unique miRnAs were analyzed, which interestingly had significant commonality. This suggests that miRNAs that are commonly de-regulated and specifically altered in multiple cancers might regulate similar pathways to promote cancer. Our data is of significance because we not only identify a set of common and unique miRnAs for multiple cancers but also highlight the pathways regulated by them, which might facilitate the development of future non-invasive biomarkers conducive for early detection of cancers.

show abstract

“…Over the past two decades, the regulation of the physiological and pathophysiological processes mediated by miRNAs has been widely studied, including in cancer studies and in studies on inflammatory and infectious diseases [5,[20][21][22][23], as has the identification of miRNAs as a biomarker for infection and for the prognosis of diseases [24][25][26]. Our previous data revealed that the entrance of the parasite into the macrophages initiated the expression of miRNAs.…”

Section: Introductionmentioning

confidence: 99%

miR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensis

Acuña

Zanatta

Bento

et al. 2022

ncRNA

View full text Add to dashboard Cite

MicroRNAs are small non-coding RNAs that regulate cellular processes by the post-transcriptional regulation of gene expression, including immune responses. The shift in the miRNA profiling of murine macrophages infected with Leishmania amazonensis can change inflammatory response and metabolism. L-arginine availability and its conversion into nitric oxide by nitric oxide synthase 2 (Nos2) or ornithine (a polyamine precursor) by arginase 1/2 regulate macrophage microbicidal activity. This work aimed to evaluate the function of miR-294, miR-301b, and miR-410 during early C57BL/6 bone marrow-derived macrophage infection with L. amazonensis. We observed an upregulation of miR-294 and miR-410 at 4 h of infection, but the levels of miR-301b were not modified. This profile was not observed in LPS-stimulated macrophages. We also observed decreased levels of those miRNAs target genes during infection, such as Cationic amino acid transporters 1 (Cat1/Slc7a1), Cat2/Slc7a22 and Nos2; genes were upregulated in LPS stimuli. The functional inhibition of miR-294 led to the upregulation of Cat2 and Tnfa and the dysregulation of Nos2, while miR-410 increased Cat1 levels. miR-294 inhibition reduced the number of amastigotes per infected macrophage, showing a reduction in the parasite growth inside the macrophage. These data identified miR-294 and miR-410 biomarkers for a potential regulator in the inflammatory profiles of microphages mediated by L. amazonensis infection. This research provides novel insights into immune dysfunction contributing to infection outcomes and suggests the use of the antagomiRs/inhibitors of miR-294 and miR-410 as new therapeutic strategies to modulate inflammation and to decrease parasitism.

show abstract

Potential Role of MicroRNA-375 as Biomarker in Human Cancers Detection: A Meta-Analysis

Cited by 11 publications

References 39 publications

Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Assessing MicroRNA-375 Levels in Type 2 Diabetes Mellitus (T2DM) Patients and Their First-Degree Relatives with T2DM

Common and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression

miR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensis

Contact Info

Product

Resources

About