Potential Secondary Pathogenic Role for Bovine Herpesvirus 4

Donofrío, Gaetano; Cavirani, S.; Santen, Vicky L. van; Flammini, C. F.

doi:10.1128/jcm.43.7.3421-3426.2005

Cited by 35 publications

(40 citation statements)

References 19 publications

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“…Given the fact that BHV-4 may be isolated from both healthy and diseased animals, it is difficult to determine its role and significance in the development of pathological processes. In vitro investigations suggest that BHV-4 contribute to disease development by stimulation of the inflammatory reaction (Donofrio et al 2005). …”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bovine herpesvirus type 4 in aborting dairy cows

Cvetojevic¹,

Savić²,

Milićević³

et al. 2016

Polish Journal of Veterinary Sciences

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Bovine herpesvirus type 4 (BHV-4) is related to many different conditions: infertility, postpartal metritis, vulvovaginitis, mastitis, encephalitis, calf pneumonia, keratoconjunctivitis, cutaneous lesions, digital dermatitis and abortion. In this study a retrospective PCR examination of 100 extracted DNA samples from aborting cows was performed in order to determine: prevalence of BHV-4 in abortive cattle, whether coinfections BHV-4 with other abortifacient pathogens are present in the same sample and to determine the month of gestation when BHV-4 associated abortions were detected. Out of 100 examined samples, the BHV-4 genome was detected in 21 samples (21%). In two samples we detected coinfection of BHV-4 with bovine viral diarrhea virus (BVDV) and in one with Neospora caninum. Most of the BHV-4-associated abortions were detected during the seventh month of gestation. It was concluded that an active BHV-4 infection was present among cows that aborted on the farms examined. The high prevalence of the BHV-4 genome in abortion material suggests that this virus may have cause the abortions. Further studies and examinations are needed to establish causative connection between presence of BHV-4 and abortion.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Bovine herpesvirus type 4 in aborting dairy cows

Cvetojevic¹,

Savić²,

Milićević³

et al. 2016

Polish Journal of Veterinary Sciences

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“…BOMAC cells are suitable hosts for bovine virus cultivation (Donofrio et al 2005), and were used for investigating interactions with intracellular parasite (Theileria annulata) gene (Shiels et al 2004) or for analysis of gene expression after virus infection (Rola et al 2011). We stimulated BOMA monocytes/macrophages with Fh-ES what resulted in no TNF-α change, but LPS activated BOMA cells diminished release of TNF-α after Fh-ES stimulation.…”

Section: Discussionmentioning

confidence: 99%

Fasciola hepatica — the pilot study of in vitro assessing immune response against native and recombinant antigens of the fluke

Bąska

Zawistowska-Deniziak

Zdziarska

et al. 2013

Acta Parasitologica

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Fasciola hepatica is a liver fluke that infects 2.4 million of people and causes great economical loss in animal production. To date a 100% effective vaccine has not been developed and the disease is controlled by drug therapy. Great efforts are put into development of effective vaccine against parasite what is difficult since Fasciola spp. (like other helmints) during evolutionary process has developed sophisticated and efficient methods to evade immune response. During preliminary experiments it is convenient to use cell lines which are relatively cheap and allow for reproducible comparison of results between laboratories. We stimulated BOMA (bovine monocyte/macrophage cell line) and BOMAC (bovine macrophage cell line) with native or recombinant antigens of Fasciola hepatica and assessed IFN-γ, IL-4 and TNF-α level upon stimulation. We observed diminished secretion of proinflammatory TNF-α in LPS activated BOMA cells stimulated with Excretory/Secretory products of adult fluke (Fh-ES). We also observed greater changes in gene expression in LPS activated BOMA cells than in non activated BOMA cells upon stimulation using Fh-ES. The results show possibility of using cell lines for in vitro research of bovine immune response against liver fluke, although this model still requires validation and further characterization.

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“…The isolation of BHV-4 from the CNS of an animal that had neurologic signs but no gross or histo- logic lesions is likely an incidental finding, with no clinical significance in this case. This virus has been secondarily associated with cases of infertility, abortion and mastitis (Donofrio et al 2005, Deim et al 2007. Listeria monocytogenes can produce facial paralysis and vestibular signs but the epidemiology, the very low mortality, and the absence of the characteristic microabscesses in histological sections of the brainstem rule this agent out.…”

Section: Discussionmentioning

confidence: 99%

Facial paralysis and vestibular syndrome in feedlot cattle in Argentina

Odriozola¹,

Diab²,

Khalloub³

et al. 2009

Pesq. Vet. Bras.

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This paper reports 6 outbreaks of neurological disease associated with paralysis of the facial and vestibulocochlear nerves caused by intracranial space occupying lesions in feedlot cattle. The clinical signs observed were characterized by head tilt, uni or bilateral drooping and paralysis of the ears, eyelid ptosis, keratoconjunctivitis, and different degrees of ataxia. Morbidity and mortality rates ranged from 1.1 to 50% and 0 to 1%, respectively. Gross lesions observed included yellow, thickened leptomeninges, and marked enlargement of the roots of cranial nerves VII (facial) and VIII (vestibulocochlear). Histopathologically, there was severe, chronic, granulomatous meningitis and, in one case, chronic, granulomatous neuritis of the VII and VIII cranial nerves. Attempts to identify bacterial, viral, or parasitic agents were unsuccessful. Based on the morphologic lesions, the clinical condition was diagnosed as facial paralysis and vestibular syndrome associated with space occupying lesions in the meninges and the cranial nerves VII and VIII. Feedlot is a practice of growing diffusion in our country and this is a first report of outbreaks of facial paralysis and vestibular disease associated with space occupying lesions in Argentina.

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Potential Secondary Pathogenic Role for Bovine Herpesvirus 4

Cited by 35 publications

References 19 publications

Prevalence of Bovine herpesvirus type 4 in aborting dairy cows

Prevalence of Bovine herpesvirus type 4 in aborting dairy cows

Fasciola hepatica — the pilot study of in vitro assessing immune response against native and recombinant antigens of the fluke

Facial paralysis and vestibular syndrome in feedlot cattle in Argentina

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