Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer

Abstract

Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulating cell signaling pathways. Resveratrol is a well-known polyphenolic molecule with antioxidant, anti-inflammatory, and health-prompting effects among which its anticancer role has been best defined. Additionally, this polyphenol has confirmed its role in cancer management because it activates tumor suppressor genes, suppresses cell proliferation, induces apoptosis, inhibits angiogenesis, and modulates several other cell signaling molecules. The anticancer potential of resveratrol is recognized in numerous in vivo and in vitro studies. Previous experimental data suggested that resveratrol may be valuable in cancer management or improve the efficacy of drugs when given with anticancer drugs. This review emphasizes the potential role of resveratrol as an anticancer drug by modulating numerous cells signaling pathways in different types of cancer.

Interactive Effects of Swimming High-Intensity Interval Training and Resveratrol Supplementation Improve Mitochondrial Protein Levels in the Hippocampus of Aged Rats

“…Resveratrol affects a variety of proteins and signaling pathways [ 48 ]. The current study found that this supplementation increases SIRT5 protein levels in the hippocampus of aged rats, supported by another study performed by Gertz et al [ 49 ].…”

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

“…According to various studies, resveratrol is an antioxidant, anti-inflammatory, and anticancer agent [ 25 ]. Because mitochondria play a role in both healthy and diseased states, researchers are also looking into the effect of RES on mitochondrial function and dynamics.…”

Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus Agents

“…Resveratrol (RSV, 3,4 ,5-trihydroxystilbene, Figure 1) is a well-known natural polyphenol belonging to the subclass of stilbenoids, which are synthesized by various plants, including peanuts, grapes, and blueberries, in response to physiological or stress stimuli and are present in red wine [1,2]. Many research studies conducted on RSV have demonstrated biological activity in in vitro and in vivo models and have highlighted the potential benefits of this agent for many diseases [3], such as cancer [4,5], cardiovascular disease [6], longevity [7,8], bone health [9,10], neurodegenerative [11], and infectious diseases, including those caused by DNA and RNA viruses [12][13][14][15][16]. RSV efficacy has been related to its ability to modulate several biochemical mediators, as described in many comprehensive review articles on the subject [17,18].…”