Potentiation of ethanol by <i>Coprinus atramentarius</i> in mice

Genest, K.; Coldwell, Blake B.; Hughes, Debbie

doi:10.1111/j.2042-7158.1968.tb09697.x

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…) S. F. Gray seems to be debatable. Some authors asserted that this species presents no or only a slight danger [Genest et al, 1968;Iancovitz, 19831. Furthermore, some authors recently described it as a potent toxic fungus [Laatsch, 19901 and apparently cases of poisoning have been reported [Trestdil, 19911.…”

Section: The Suspicious Fungi Speciesmentioning

confidence: 99%

Poisoning by Coprinus atramentarius

Michelot

1992

Natural Toxins

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The ink cap--Coprinus atramentarius (Bulliard ex Fries) Fries--is responsible for poisoning when ingested with alcohol. The investigation of the "Coprinus syndrome," although a minor poisoning incident, stimulated numerous research programs because the results were expected to yield a novel drug useful during the treatment of alcoholism. This work led to the identification of the active principle--coprine--and to an explanation of its mode of action; nevertheless, detailed toxicology investigations have shown that the mutagenic and gonadotoxic properties of this compound made it unsuitable for therapeutic use. Our current knowledge of the poisoning, the chemistry of the toxin, and its mode of action are here reviewed.

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Section: The Suspicious Fungi Speciesmentioning

confidence: 99%

Poisoning by Coprinus atramentarius

Michelot

1992

Natural Toxins

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“…Mice fed with suspensions of the mushroom followed by ethanol reacted with a * Present address: AB Draco, Fack, S-22101 Lund, Sweden. marked increase in sleeping-time compared to that after ethanol alone (Genest et al 1968). This interaction was accompanied by an increased bloodlevel of acetaldehyde as compared to animals receiving ethanol only (Coldwell et al 1969).…”

mentioning

confidence: 99%

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Carlsson¹,

Henning²,

Lindberg³

et al. 1978

Acta Pharmacologica et Toxicologica

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Coprine or disulfiram was given to rats in various doses at various time intervals before the administration of 2 g/kg ethanol. The ratio acetaldehyde/ethanol in the alveolar air was measured by gas chromatography and was taken as an index of the aldehyde dehydrogenase (ALDH) activity. The activity of dopamine β‐hydroxylase (DBH) was estimated in the same animals by measuring the amount of 14C‐octopamine formed from 14C‐tyramine in the heart. Coprine and disulfiram both caused an increase in the acetylaldehyde/ethanol ratio, coprine being more potent than disulfiram. Disulfiram, but not coprine, reduced the net yield of 14C‐octopamine. In rats pretreated with either coprine or disulfiram, blood‐pressure and heart‐rate were recorded before and after intraperitoneal injections of 0.4 g/kg ethanol. In both cases ethanol caused a marked and rapid fall in blood‐pressure. However, this effect was accompanied by tachycardia only in animals treated with coprine. It is concluded that coprine like disulfiram inhibits ALDH, but only disulfiram causes an additional inhibition of DBH. This difference may account for differences in the cardiovascular response to ethanol

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“…Isolation of disulfiram from C. atramentarius (9) was not confirmed (10, 11). Although no disulfiram was detected, recent investigations unequivocally confirmed that polar extracts of C. atramentarius significantly potentiate the action.of ethanol in mice (12,13). Recently, an active constituent isolated from C. atramentarius increased blood acetaldehyde levels in mice (14).…”

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confidence: 99%