Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

Hassan, Ahmed K.; Ameen, Suhaam T.; Saad, Bahruddin; Al-Aragi, Suad M.

doi:10.2116/analsci.25.1295

Cited by 12 publications

(5 citation statements)

References 25 publications

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“…Also, other types of techniques have been used: indirect atomic absorption method 12 . Voltammetry method 13 , Potentiometric sensors 14 . Electrochemical Sensing 15 .…”

Section: Fig 1: Chemical Structure Of Trifluoperazine-hclmentioning

confidence: 99%

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Hussein,

Nabbel

2023

Journal of Pharmaceutical and Applied Chemistry

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The estimation of trifluoperazine hydrochloride in pure and dosage forms has been developed using a simple spectrophotometric approach. The method employs an oxidation-reduction reaction with ceric sulfate in acidic medium the unreacted oxidant bleaches the color of complex prepared previously outside the reaction medium from reaction of 4,7diphenyl 1,10phenanthroline with ferrous ammonium sulfate to produce a red-violet colored product with a maximum absorbance of 533nm. The molar absorptivity of 0.700x10 4 L. mole -1 .cm -1 , Beer's law is followed over a concentration range of 1.25-62.5 µg ml-1. The proposed approach was successfully used to determine trifluoperazine hydrochloride in tablets. For the determination of trace quantities of TFPH, a simple, fast, exact, and sensible spectrophotometric approach has been suggested.

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“…Also, other types of techniques have been used: indirect atomic absorption method 12 . Voltammetry method 13 , Potentiometric sensors 14 . Electrochemical Sensing 15 .…”

Section: Fig 1: Chemical Structure Of Trifluoperazine-hclmentioning

confidence: 99%

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Hussein,

Nabbel

2023

Journal of Pharmaceutical and Applied Chemistry

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“…Several approaches are used for the detection of TFP including spectrophotometry, 1 capillary-zone electrophoresis, 2 titrimetry, 3 fluorometry, 4 high-performance liquid chromatography, 5 etc. There are few reports for TFP determination by electrochemical methods using potentiometric sensor, 6 modified gold electrode, 7 carbon paste electrode, 8 wax-impregnated graphite electrode, 9 and poly-ABSA/ SWNT film-modified glassy carbon electrode. 10 These previously reported methods lack adequate sensitivity with relatively high detection limits for TFP.…”

Section: Trifluoperazine (Tfp) Has the Chemical Name Of 10-[3-(4-meth...mentioning

confidence: 99%

Hematite Nanoparticles/Ionic Liquid Crystal/Graphene–Based Nanocomposite Electrochemical Sensor for Sensitive Determination of Antipsychotic Drug

Atta

Ahmed

BinSabt

et al. 2016

J. Electrochem. Soc.

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Psychotic symptoms have been widely spread and several drugs have been proposed to suppress its consequences including trifluoperazine (TFP). Here we introduce an electrochemical sensor based on glassy carbon electrode modified with a composite of hematite nanoparticles (FeNPs)/ionic liquid crystal (ILC)/graphene (RGO) for simple and direct determination of TFP. The sensor proved to be highly effective and sensitive due to the synergistic effects of FeNPs, ILC and RGO. The electrocatalytic oxidation of TFP was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Surface morphology was examined by scanning electron microscopy (SEM). Various figures of merit were evaluated including effects of pH and scan rates on the voltammetric response of TFP. Under optimal operational conditions, linear response was in the concentration range of 9 × 10 −10 to 1 × 10 −7 mol L −1 and 2 × 10 −6 to 2 × 10 −4 mol L −1 for TFP with correlation coefficients 0.997 and 0.998, respectively. The lower limits of detection and quantification were 2.29 × 10 −12 mol L −1 and 7.65 × 10 −12 mol L −1 , respectively. The sensor showed good stability, reproducibility, repeatability, anti-interference ability and selectivity. It was possible to determine TFP in real human samples and pharmaceutical formulations.

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“…Trifluoperazine (10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine, TFP) is a dopamine antagonist with antipsychotic and antiemetic activities mainly used for schizophrenia treatment. 1 TFP is one of the most potent antipsychotic phenothiazine-type drugs that express its antipsychotic effect by blocking central dopamine receptors and prevent effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to an increase of cytosolic calcium.…”

Section: ■ Introductionmentioning

confidence: 99%

Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe₃O₄ Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine

Ognjanović

Stanković

Jović

et al. 2020

ACS Appl. Nano Mater.

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Here, we report the design of a disposable singledrop voltammetric sensor for the quantitative determination of antipsychotic drug trifluoperazine (TFP). The sensor was built using inkjet-printed carbon nanotube (CNT) electrodes, which were modified with dimercaptosuccinic acid (DMSA)-coated magnetite nanoparticles uniformly dispersed over reduced graphene oxide nanosheets (DMSA/Fe 3 O 4 /RGO). The used modifying materials were characterized by electron microscopy techniques (transmission electron microscopy (TEM) and field emission-scanning electron microscopy (FE-SEM)), X-ray powder diffraction, ζ-potential measurements, dynamic light scattering (DLS), and electrochemical methods (cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS)). The developed sensor, best operated at pH 7 in the Britton−Robinson buffer solution (BRBS), shows linear electrocatalytic activity with TFP in the concentration range of 1−50 μM, a low detection limit of 0.54 μM, and excellent selectivity, repeatability, and reproducibility with an relative standard deviation (RSD) of 2.4%. A voltammetric approach using square wave voltammetry (SWV) is a sensitive technique under optimized conditions for the analytical determination of submicromolar amounts of TFP. Bare CNT and RGO-and DMSA/Fe 3 O 4 -modified CNT electrodes showed lower electrocatalytic activity than the DMSA/Fe 3 O 4 /RGO/CNT electrode. The development of this kind of TFP sensor based on nanoparticle-decorated graphene nanosheets can offer a tool for point-of-care applications as sensors in biomedicine.

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Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

Abstract: Experimental Reagents and chemicalsAll chemicals were of analytical-reagent grade. Doubly deionized water was used to prepare all solutions. High-molecular-weight poly(vinyl chloride) (PVC), di-n-butyl 2009

Cited by 12 publications

References 25 publications

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Hematite Nanoparticles/Ionic Liquid Crystal/Graphene–Based Nanocomposite Electrochemical Sensor for Sensitive Determination of Antipsychotic Drug

Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe₃O₄ Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine

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Potentiometric Sensors for the Determination of Trifluoperazine Hydrochloride in Pharmaceutical Preparations

Abstract: Experimental Reagents and chemicalsAll chemicals were of analytical-reagent grade. Doubly deionized water was used to prepare all solutions. High-molecular-weight poly(vinyl chloride) (PVC), di-n-butyl 2009

Cited by 12 publications

References 25 publications

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Development of a new indirect method for the determination of Trifluuperazine HCl in pharmaceutical formulations.

Hematite Nanoparticles/Ionic Liquid Crystal/Graphene–Based Nanocomposite Electrochemical Sensor for Sensitive Determination of Antipsychotic Drug

Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe3O4 Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine

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Product

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About

Inkjet-Printed Carbon Nanotube Electrodes Modified with Dimercaptosuccinic Acid-Capped Fe₃O₄ Nanoparticles on Reduced Graphene Oxide Nanosheets for Single-Drop Determination of Trifluoperazine