2020
DOI: 10.1080/10495398.2020.1798974
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Pou2F3 silencing enhanced the proliferation of mammary epithelial cells in dairy goat via PI3K/AKT/mTOR signaling pathway

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Cited by 3 publications
(3 citation statements)
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“…Furthermore, we next conducted SCENIC analysis to identify the decisive regulators of the epithelial subsets between HSIL and CA (Figure 2J). Strikingly, BRCA1, 25 which play a crucial role in DNA replication, DNA repair and genomic stability maintenance, 26 predominantly regulates the HPV‐related HSIL cluster, whereas TP63, ELF3 and POU2F3 modulate the abnormal proliferation and differentiation of epithelial cells in the HPV‐related CA cluster 27,28 . Overall, we creatively discovered 12 critical node genes and 5 regulons during the progression from the HPV‐infected normal cervix to HSIL to CA.…”
Section: Resultsmentioning
confidence: 93%
See 1 more Smart Citation
“…Furthermore, we next conducted SCENIC analysis to identify the decisive regulators of the epithelial subsets between HSIL and CA (Figure 2J). Strikingly, BRCA1, 25 which play a crucial role in DNA replication, DNA repair and genomic stability maintenance, 26 predominantly regulates the HPV‐related HSIL cluster, whereas TP63, ELF3 and POU2F3 modulate the abnormal proliferation and differentiation of epithelial cells in the HPV‐related CA cluster 27,28 . Overall, we creatively discovered 12 critical node genes and 5 regulons during the progression from the HPV‐infected normal cervix to HSIL to CA.…”
Section: Resultsmentioning
confidence: 93%
“…Strikingly, BRCA1, 25 which play a crucial role in DNA replication, DNA repair and genomic stability maintenance, 26 predominantly regulates the HPV‐related HSIL cluster, whereas TP63, ELF3 and POU2F3 modulate the abnormal proliferation and differentiation of epithelial cells in the HPV‐related CA cluster. 27 , 28 Overall, we creatively discovered 12 critical node genes and 5 regulons during the progression from the HPV‐infected normal cervix to HSIL to CA. These findings could facilitate accurate molecular subtyping and provide novel insights for the precise intervention of cervical lesions and tumours in clinical practice.…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, the role of HSP47 in NSCLC remains to be explored. Furthermore, protein kinase B (AKT) signaling is implicated in a number of fundamental cellular processes, including proliferation [17] and survival [18]. Moreover, AKT also plays a regulatory role in angiogenesis and metabolism [19], in addition to modulating various cellular survival pathways, primarily as an inhibitor of apoptosis [20].…”
Section: Introductionmentioning
confidence: 99%