SummaryIn this article, a power‐efficient hybrid voltage up level shifter (LS) is designed. By using a combination of a current mirror (CM) and a cross‐coupled pMOS pair in a pull‐up circuitry, the dynamic power is reduced significantly even at boosted switching speed. The designed LS circuit, which occupies a small silicon area, consists of 10 transistors and is mainly suitable for ultra‐low‐power applications, such as wireless sensor nodes and biomedical appliances. Moreover, it can convert extreme low‐level input voltages to the high supply voltage levels. The results obtained from post‐layout simulations in a standard 180‐nm CMOS process illustrate that the designed LS circuit has total power consumption, static power dissipation, and propagation delay of 33.93 nW, 253 pW, and 9.09 ns, respectively, at 1 MHz with a minimum supply voltage (VDDL) of 0.4 V and nominal supply voltage (VDDH) of 1.8 V. Also, the designed LS can convert an input voltage of 0.12–1.8 V at 10 kHz.