Powering the Future: How Can Electrochemistry Make a Difference in Organic Synthesis?

Meyer, Tjark H.; Choi, Isaac; Tian, Cong; Ackermann, Lutz

doi:10.1016/j.chempr.2020.08.025

Cited by 345 publications

(167 citation statements)

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“… 6 Particularly, organic electrochemistry has in recent years overcome some of its past limitations as a niche technique. 7 Electroorganic synthesis can indeed be traced back to the 19th century with Faraday’s hydrolysis of acetic acid to hydrocarbons 8 and Kolbe’s electrochemical decarboxylative dimerization ( Figure 1 ). 9 Hence, in the early twentieth century, Hickeling proposed that reactions could be conducted under potentiostatic control, rather than constant-current electrolysis.…”

Section: Introductionmentioning

confidence: 99%

Organic Electrochemistry: Molecular Syntheses with Potential

et al. 2021

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Efficient and selective molecular syntheses are paramount to inter alia biomolecular chemistry and material sciences as well as for practitioners in chemical, agrochemical, and pharmaceutical industries. Organic electrosynthesis has undergone a considerable renaissance and has thus in recent years emerged as an increasingly viable platform for the sustainable molecular assembly. In stark contrast to early strategies by innate reactivity, electrochemistry was recently merged with modern concepts of organic synthesis, such as transition-metal-catalyzed transformations for inter alia C–H functionalization and asymmetric catalysis. Herein, we highlight the unique potential of organic electrosynthesis for sustainable synthesis and catalysis, showcasing key aspects of exceptional selectivities, the synergism with photocatalysis, or dual electrocatalysis, and novel mechanisms in metallaelectrocatalysis until February of 2021.

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Section: Introductionmentioning

confidence: 99%

Organic Electrochemistry: Molecular Syntheses with Potential

et al. 2021

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“…Meyer et al . have highlighted four examples of cases where electrosynthesis can be seen to impact on the development of sustainable chemical technologies [11] . Organic electrosynthesis can be seen to increasingly make the jump from laboratory to industrial application, particularly when based on microreactors, flow, and based on paired processes [12] .…”

Section: Introduction To Paired Electrosynthesis With Innocent/sacrificial Reactionsmentioning

confidence: 99%

Recent Advances in Paired Electrosynthesis

Marken

Cresswell

Bull

2021

The Chemical Record

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Progress in electroorganic synthesis is linked to innovation of new synthetic reactions with impact on medicinal chemistry and drug discovery and to the desire to minimise waste and to provide energy‐efficient chemical transformations for future industrial processes. Paired electrosynthetic processes that combine the use of both anode and cathode (convergent or divergent) with minimal (or without) intentionally added electrolyte or need for additional reagents are of growing interest. In this overview, recent progress in developing paired electrolytic reactions is surveyed. The discussion focuses on electrosynthesis technology with proven synthetic value for the preparation of small molecules. Reactor types are contrasted and the concept of translating light‐energy driven photoredox reactions into paired electrolytic reactions is highlighted as a newly emerging trend.

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“…Therefore, in this review we are focusing on the recent developments in the design of enabling green strategies for otherwise activation of the inert C-H bonds towards improved sustainability and resource-economy. 11…”

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confidence: 99%