PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus

Li, Tao; Xu, Xiaoyan; Xu, Yi; Jin, Peiyao; Chen, Jianhua; Shi, Yongyong; Zou, Haidong

doi:10.1155/2019/5284867

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…1 It is known to all that chronic diabetes could cause many complications such as retinopathy, kidney disease, diabetes foot, heart disease and so forth. [2][3][4][5][6] Therefore, the timely treatment is extremely important.…”

Section: Introductionmentioning

confidence: 99%

<p>The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis</p>

Zhou

2020

DMSO

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Purpose: Mulberry leaf extract has exerted better antidiabetic activities, while the effects of major active components in mulberry leaf extract are still unclear. Cryptochlorogenic acid (CCA) as the major active component in mulberry leaf extracts was investigated herein. Materials and Methods: Rats were treated with 50mg/kg streptozotocin for the establishment of diabetic model in vivo, and cells were treated with 33.3 mM glucose for the establishment of cell model in vitro. HE staining assay was performed for observation of pancreatic pathology and aldehyde fuchsin staining assay for examining islet cell numbers. The iron content was detected via Perls staining assay with iron assay kit (ab83366). The malondialdehyde (MDA), glutathione (GSH) and oxidized glutathione (GSSG) were detected by corresponding kits. Real-time quantitative polymerase chain reaction (RT-qPCR) was performed for assessment of gene level and Western blot for measurement of protein expression level. The cell survival was detected via CCK-8 assay. Results: The blood glucose level, iron content, accumulation of lipid peroxides and islet injury in diabetic model were all improved by CCA via a concentration-dependent manner. CCA functions via inhibition of ferroptosis by activation of cystine/glutamate transporter system (XC − )/glutathione peroxidase 4(GPX4)/Nrf2 and inhibition of nuclear receptor coactivator 4 (NCOA4) in diabetes. Conclusion: CCA exerted excellent antidiabetic effects via inhibition of ferroptosis, so it may be a promising agent for diabetes therapy, providing a new avenue for diabetes treatment.

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Section: Introductionmentioning

confidence: 99%

<p>The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis</p>

Zhou

2020

DMSO

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“…The PPARG variant, rs1801282, is important in the development of obesity as well as adipose and muscle tissue metabolism [ 33 ]. This variant has recently been investigated in the development of early visual impairment in T2DM Chinese Han population [ 33 ] and been associated with obstructive sleep apnea in Chinese Han and Indian subjects diagnosed with T2DM [ 34 , 35 ]. Obesity is a known comorbid disease of diabetes and sleep apnea has also been associated with diabetes, therefore, this variant was included for investigation.…”

Section: Discussionmentioning

confidence: 99%

Genetic association of solute carrier transporter gene variants with metformin response

Abrahams-October

Xhakaza

Pearce

et al. 2021

Balkan Journal of Medical Genetics

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Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic drugs, however, response to treatment is highly variable with patients failing to achieve adequate glycemic control. Treatment response variability has been associated with single nucleotide polymorphisms (SNPs) which influence the pharma-cokinetics and pharmacodynamics of drug(s). The aim of this study was to evaluate the genetic association of 17 SNPs and the response to metformin therapy in patients diagnosed with diabetes from the indigenous Nguni population of South Africa. One hundred and forty indigenous African patients diagnosed with T2DM were recruited and genotyped using the MassARRAY® system. Therapeutic response of patients was ascertained by a change in Hb A1c. Two SNPs (rs1801282 and rs6265) were monomorphic. All other variants were within the Hardy-Weinberg equilibrium (HWE). The T allele of the SLC variant rs316009 [odds ratio (OR) = 0.25, 95% confidence interval (95% CI) = 0.01-0.09, p value = 0.044] and the CT genotype of the PCK1 variant rs4810083 (OR = 2.80, 95% CI = 1.01-7.79, p value = 0.049) were associated with an improved response to treatment after adjustment. No association was observed with post Bonferroni correction. Moreover, this study provides important additional data regarding possible associations between genetic variants and metformin therapy outcomes. In addition, this is one of the first studies providing genetic data from the understudied indigenous sub-Saharan African populations.

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“…The World Health Organization uses a threshold of 20/60 for visual impairment, while 20/40 is used as the standard of visual impairment for research purposes [ 32 – 34 ]. VA ≤ 20/25 (loss of 1 line) indicates mild poor vision, which means the individual may have mild difficulty in daily life without spectacles [ 35 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study

et al. 2022

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Background Decreased visual acuity (VA) is reported to be a risk factor for dementia. However, the association between VA and cortical thickness has not been established. We investigated the association between VA and cortical thickness in cognitively normal adults. Method We conducted a cross-sectional, single-center cohort study with cognitively normal adults (aged ≥ 45) who received medical screening examinations at the Health Promotion Center at Samsung Medical Center. Subjects were categorized as bad (VA ≤ 20/40), fair (20/40 < VA ≤ 20/25), and good (VA > 20/25) VA group by using corrected VA in the Snellen system. Using 3D volumetric brain MRI, cortical thickness was calculated using the Euclidean distance between the linked vertices of the inner and outer surfaces. We analyzed the association between VA and cortical thickness after controlling for age, sex, hypertension, diabetes, dyslipidemia, intracranial volume, and education level. Results A total of 2756 subjects were analyzed in this study. Compared to the good VA group, the bad VA group showed overall thinner cortex (p = 0.015), especially in the parietal (p = 0.018) and occipital (p = 0.011) lobes. Topographical color maps of vertex-wise analysis also showed that the bad VA group showed a thinner cortex in the parieto-temporo-occipital area. These results were more robust in younger adults (aged 45 to 65) as decreased VA was associated with thinner cortex in more widespread regions in the parieto-temporo-occipital area. Conclusion Our results suggest that a thinner cortex in the visual processing area of the brain is related to decreased visual stimuli.

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PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus

Cited by 9 publications

References 40 publications

<p>The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis</p>

<p>The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis</p>

Genetic association of solute carrier transporter gene variants with metformin response

Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study

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