2016
DOI: 10.1038/cdd.2016.6
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PPARγ neddylation essential for adipogenesis is a potential target for treating obesity

Abstract: The preadipocyte-to-adipocyte differentiation (adipogenesis) is a key process in fat mass increase and thus it is regarded as a compelling target for preventing or treating obesity. Of adipogenic hormone receptors, peroxisome proliferator-activated receptor gamma (PPARγ) has crucial roles in adipogenesis and lipid accumulation within adipocytes. Here we demonstrate that the NEDD8 (neuronal precursor cell expressed, developmentally downregulated 8)-based post-translation modification (neddylation) of PPARγ is e… Show more

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Cited by 77 publications
(71 citation statements)
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“…Therefore, we speculate that an antagonistic relationship may exist between neddylation and ubiquitination of SREBP‐1 as they compete to bind on the same lysine residue in tumor cells. This idea is in line with another report that neddylated PPARγ is stabilized through the inhibition of ubiquitination at the same domain of PPARγ 35 . Nonetheless, the actual residue involved in SREBP‐1 neddylation remains to be elucidated.…”
Section: Discussionsupporting
confidence: 86%
“…Therefore, we speculate that an antagonistic relationship may exist between neddylation and ubiquitination of SREBP‐1 as they compete to bind on the same lysine residue in tumor cells. This idea is in line with another report that neddylated PPARγ is stabilized through the inhibition of ubiquitination at the same domain of PPARγ 35 . Nonetheless, the actual residue involved in SREBP‐1 neddylation remains to be elucidated.…”
Section: Discussionsupporting
confidence: 86%
“…The gene network may be associated with PParG, as increased expression of PParG was detected in visceral adipose tissue in our previous study (18). PParG, which is widely described as playing an important role in adipocyte proliferation and differentiation, as well as in the conversion of various cells into adipose-like cells (25)(26)(27)(28)(29)(30), was implicated in the visceral adipose tissue accumulation of the experimental rats in the present study. PParG expression is also potentially associated with serum levels of c-c motif chemokine ligand 2 and interleukin-6 in rats (18), which may facilitate the accumulation of visceral adipose tissue, indicating that PParG serves a role in this phenomenon.…”
Section: Discussionsupporting
confidence: 55%
“…Suspected HFRS patients were diagnosed according to the criteria in the < Diagnostic criteria for epidemic hemorrhagic fever WS278-2008> issued by the Ministry of Health of China in 200819.…”
Section: Methodsmentioning
confidence: 99%