The intense research activity on Twin-Field (TF) quantum key distribution (QKD) is motivated by the fact that two users can establish a secret key by relying on single-photon interference in an untrusted node. Thanks to this feature, variants of the protocol have been proven to beat the point-to-point private capacity of a lossy quantum channel. Here we generalize the main idea of the TF-QKD protocol introduced by Curty et al to the multipartite scenario, by devising a conference key agreement (CKA) where the users simultaneously distill a secret conference key through single-photon interference. The new CKA is better suited to high-loss scenarios than previous multipartite QKD schemes and it employs for the first time a W-class state as its entanglement resource. We prove the protocol's security in the finite-key regime and under general attacks. We also compare its performance with the iterative use of bipartite QKD protocols and show that our truly multipartite scheme can be advantageous, depending on the loss and on the state preparation.The most mature and developed application of quantum communication [1, 2] is certainly quantum key distribution (QKD) [3][4][5][6][7][8]. The majority of the QKD protocols proposed so far involve just two end-users, Alice and Bob, who want to establish a secret shared key. Nowadays there is a vibrant research towards protocols which are proven to be secure in the most adversarial situation possible (i.e. reducing the assumption on the devices) [9-14], but at the same time are also implementable with today's technology [15][16][17][18]. In this context, a protocol which recently received great attention is the Twin-Field (TF) QKD protocol originally proposed by Lucamarini et al [19], further developed to prove its security [20][21][22][23][24][25][26][27] and experimentally implemented [28][29][30][31]. Indeed, the TF-QKD protocol relies only on single-photon interference occurring in an untrusted node, making it a measurement-device-independent (MDI) QKD protocol capable of overcoming the repeaterless bounds [32,33].In a scenario where several users are required to share a common secret key, one can for instance perform bipartite QKD protocols between pairs of users and then use the secret keys established in this way to encode the final common secret key. Alternatively, one can perform a truly multipartite QKD scheme-also known as conference key agreement (CKA)-whose purpose is to deliver the same secret key to all the parties involved in the protocol [35][36][37][38][39]. In order to accomplish such a task, a resource which seems necessary is the multipartite Greenberger-Horne-Zeilinger (GHZ) state [34][35][36][37][38] or a multipartite private state-a 'twisted' version of the GHZ state [40,41].In this work we introduce a CKA which exploits for the first time the multipartite entanglement of a W-class state [42], in order to deliver the same secret key to all users. Despite having a number of users involved, the scheme relies on single-photon interference in an untrusted no...