Pre- and per-treatment 18F-FDG PET/CT parameters to predict recurrence and survival in cervical cancer

Leseur, J.; Roman-Jimenez, Geoffrey; Devillers, Anne; Arango, Juan David Ospina; Williaume, D.; Castelli, J.; Tervé, Pierre; Lavoué, Vincent; Garin, Étienne; Lejeune, Florence; Acosta, Oscar; Crevoisier, R. de

doi:10.1016/j.radonc.2016.08.008

Cited by 41 publications

(45 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study is the first to report that TLR and tumor SUVmax have potential clinical significance in predicting recurrence in stage IIA CRC. Metabolic parameters from 18 F–FDG-PET/CT, such as SUVmax, have previously been reported as strong prognostic factors for a number of malignancies, including lung cancer, esophageal cancer, lymphoma, cervical cancer, and intrahepatic cholangiocarcinoma [ 8 , 21 – 26 ]. Moreover, elevated SUVmax in the primary tumor has been associated with poor prognosis in patients with CRC [ 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Huang

Zhou

et al. 2017

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

PurposeThe prognostic value of the tumor-to-liver uptake ratio (TLR) from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F–FDG-PET/CT) in the early stage of colorectal cancer (CRC) is unclear. Notably, some stage IIA CRC patients experience early recurrence even after curative resection and might benefit from neoadjuvant or adjuvant chemotherapy. This study aims to evaluate whether elevated TLR from 18F–FDG-PET/CT can predict poor prognosis in stage IIA CRC patients undergoing curative resection.MethodsFrom April 2010 to December 2013, 504 consecutive CRC patients with different TNM stages (I-IV) underwent 18F–FDG-PET/CT scans at the 6th Affiliated Hospital of Sun Yat-Sen University. Among the patients, 118 with stage IIA CRC who accepted preoperative 18F–FDG-PET/CT scanning and were treated with curative surgery alone were reviewed retrospectively. The maximum standardized uptake value (SUVmax) in the primary tumor, TLR, and demographic, clinical, histopathological, and laboratory data were analyzed. Receiver operating characteristic (ROC) curve, univariate and multivariate analyses were performed to identify prognostic factors associated with patient disease-free survival (DFS) and overall survival (OS).ResultsROC curve analysis demonstrated that TLR was superior to primary tumor SUVmax in predicting the risk of recurrence in stage IIA CRC. The optimal TLR cutoff was 6.2. Univariate analysis indicated that elevated TLR, tumor size, and lymphovascular/neural invasion correlated with DFS (P = 0.001, P = 0.002, and P = 0.001, respectively) and OS (P = 0.001, P = 0.003, and P < 0.001, respectively). The 1-, 3-, and 5-year DFS rates were 98.4%, 96.9%, and 96.9% for stage IIA CRC patients with lower TLR (≤6.2) versus 77.8%, 60.6%, and 60.6% for those with elevated TLR (>6.2), respectively. The 1-, 3-, and 5-year OS rates were 100.0%, 100.0%, and 98.3% for the patients with lower TLR versus 98.1%, 83.3%, and 74.3% for those with elevated TLR. Cox regression analysis showed that elevated TLR [>6.2; hazard ratio (HR): 3.109–57.463; P < 0.001] and tumor size (>4.4 cm; HR: 1.636–19.155; P = 0.006) were independent risk factors for DFS. Meanwhile, elevated TLR (>6.2; HR: 1.398–84.945; P = 0.023) and lymphovascular/neural invasion (positive; HR: 1.278–12.777; P = 0.017) were independent risk factors for OS.ConclusionElevated TLR predicted worse DFS and OS for stage IIA CRC patients and might serve as a potential radiological index to identify candidates for neoadjuvant or adjuvant chemotherapy. Stage IIA CRC patients with elevated TLR should be monitored carefully for early detection of possible recurrence.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Huang

Zhou

et al. 2017

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Literature showed accuracies of 76 to 90% for staging of Locally Advanced Cervical Cancer (LACC) using MRI [7], compared to 60 to 69% for CT (Computed Tomography) [8]. However, even if conventional semi-quantitative PET indices such as Standardized Uptake Value (SUV), Metabolic Volume (MV) or Total Lesion Glycolysis (TLG) have proved useful as prognostic factors in LACC [6, 9], more information extracted from images holds promise to further increase the prognostic value of PET.…”

Section: Introductionmentioning

confidence: 99%

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

et al. 2017

View full text Add to dashboard Cite

ObjectivesTo identify an imaging signature predicting local recurrence for locally advanced cervical cancer (LACC) treated by chemoradiation and brachytherapy from baseline 18F-FDG PET images, and to evaluate the possibility of gathering images from two different PET scanners in a radiomic study.Methods118 patients were included retrospectively. Two groups (G1, G2) were defined according to the PET scanner used for image acquisition. Eleven radiomic features were extracted from delineated cervical tumors to evaluate: (i) the predictive value of features for local recurrence of LACC, (ii) their reproducibility as a function of the scanner within a hepatic reference volume, (iii) the impact of voxel size on feature values.ResultsEight features were statistically significant predictors of local recurrence in G1 (p < 0.05). The multivariate signature trained in G2 was validated in G1 (AUC=0.76, p<0.001) and identified local recurrence more accurately than SUVmax (p=0.022). Four features were significantly different between G1 and G2 in the liver. Spatial resampling was not sufficient to explain the stratification effect.ConclusionThis study showed that radiomic features could predict local recurrence of LACC better than SUVmax. Further investigation is needed before applying a model designed using data from one PET scanner to another.

show abstract

“…SUVmax primary cervical tumour is the most commonly used metabolic parameter in current routine practice and its prognostic benefit in the management of cervical cancers has been extensively described in the literature (17,(25)(26)(27)(28). The prognostic value of primary cervical tumour MTV and TLG has been also investigated in several studies (29)(30)(31)(32)(33). In our study, none of the metabolic parameters of primary cervical tumours appeared to be correlated with OS.…”

Section: Discussionmentioning

confidence: 47%

¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

et al. 2020

View full text Add to dashboard Cite

Introduction: To use positron emission tomography coupled with computed tomography (18 FDG-PET/CT) to identify a high-risk subgroup requiring therapeutic intensification among patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) involvement. Methods: In this retrospective multicentric study, patients with LACC and PALN involvement concurrently treated with chemoradiotherapy and extended-field radiotherapy (EFR) between 2006 and 2016 were included. A senior nuclear medicine specialist in PET for gynaecologic oncology reviewed all 18 FDG-PET/CT scans. Metabolic parameters including maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) were determined for the primary tumour, pelvic lymph nodes and PALN. Associations between these parameters and overall survival (OS) were assessed with Cox's proportional hazards model. Results: Sixty-eight patients were enrolled in the study. Three-year OS was 55.5% (95% CI [40.8-68.0]). When adjusted for age, stage and histology, pelvic lymph node TLG, PALN TLG and PALN SUVmax were significantly associated with OS (p<0.005). Conclusion: FDG-PET/CT was able to identify predictors of survival in the homogeneous subgroup of patients with LACC and PALN involvement, thus allowing therapeutic intensification to be proposed.

show abstract

Pre- and per-treatment 18F-FDG PET/CT parameters to predict recurrence and survival in cervical cancer

Cited by 41 publications

References 31 publications

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

Contact Info

Product

Resources

About

Pre- and per-treatment 18F-FDG PET/CT parameters to predict recurrence and survival in cervical cancer

Cited by 41 publications

References 31 publications

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Elevated tumor-to-liver uptake ratio (TLR) from 18F–FDG-PET/CT predicts poor prognosis in stage IIA colorectal cancer following curative resection

Prediction of cervical cancer recurrence using textural features extracted from 18F-FDG PET images acquired with different scanners

18F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment

Contact Info

Product

Resources

About

¹⁸F-FDG PET/CT Identifies Predictors of Survival in Patients with Locally Advanced Cervical Carcinoma and Paraaortic Lymph Node Involvement to Allow Intensification of Treatment