Pre- and Postnatal Influences of Neurohormonal Triggering and Behaviour on the Immune System of Offspring

Abstract

It has been realized for some time that exposure of the developing neonate from conception through birth to (toxic) environmental agents can affect the subsequent health and well-being of the offspring. While organogenesis (the first eight weeks of human gestation) is recognized to be a highly susceptible period for the induction of malformations, the fetal/neonatal developmental phases are now acknowledged to be just as sensitive for many well-documented developmental deficits, amongst which are immune-related disorders. In addition, developing predominantly from studies of maternal stress during pregnancy, a growing body of literature now exists to show that changes in the neurohormonal milieu of both mother/infant during pregnancy and weaning can change immune potential of the offspring. Perhaps even more provocative, there is data to suggest that immune changes in the pregnant mother can in turn modify behavior in offspring. The review below provides a framework for consideration of many of the factors contributing to such processes, and their possible mechanism(s) of action.

Introduction: Advances in Neuroimmune Biology: A Comprehensive way to Look at Biology

“…Recent research indicates that fetal/neonatal developmental phases are sensitive for many welldocumented developmental deficits, amongst which are subtle immune-related disorders. In addition, a growing body of literature now exists to show that changes in the neurohormonal milieu of both mother/infant during pregnancy and weaning can itself produce profound changes in immune potential of the offspring, and, perhaps even more provocative, that immune changes in the pregnant mother can in turn modify behavior in offspring [56].…”

Feto-Marenal Interactions – Undisputable Evidence for the Concept of Neuroimmune Biology

“…Recent observations revealed that during parturition and shortly afterwards the bodily functions of animals and babies are imprinted for life. Healthy mothers will have healthy babies with normal imprinting and sick mothers will have sick babies who will suffer from diseases all their life [28]. Thus NISS does not only affect directly mothers and babies, it has a long term effect, affecting an entire generation, affecting the maintenance of the species!!…”