Pre-eclampsia and induction of labor: A randomized comparison of prostaglandin E2 as an intracervical gel, with oxytocin immediately, or as a sustained-release vaginal insert

Concurrent oxytocin with dinoprostone pessary versus dinoprostone pessary in labour induction of nulliparas with an unfavourable cervix: a randomised placebo‐controlled trial

“…We had opted for a lower oxytocin dose regimen to minimise risk of uterine hyperstimulation syndrome and also as infusion rate of 16 mu/minute is effective in nearly 90% of women 15 . It is possible that a higher maximum oxytocin dose regimen or a longer infusion period may be more effective in reducing induction‐to‐delivery time 10–12 . However, one other previous trial that employed a higher maximum oxytocin dose has also not shown a shorter induction‐to‐delivery time with concurrent oxytocin infusion and vaginal prostaglandin for labour induction, but different prostaglandin agents (slow‐release dinoprostone plus oxytocin infusion versus multidose misoprostol) were used in the treatment arms, making it difficult to compare directly with our study 9 …”

“…Our study design was different from that of previous studies 9–12 of concurrent oxytocin with prostaglandin for labour induction in women with an unfavourable cervix in that we planned to administer oxytocin for only 6 hours at initiation of labour induction compared with earlier studies where oxytocin infusion once started usually continued until delivery. We were interested in applying oxytocin in this manner as a previous study from our centre has shown that a single membrane sweep at initiation of formal labour induction in conjunction with either vaginal dinoprostone or amniotomy has beneficial effects, 5 and we were interested to establish whether ‘frontloading’ with oxytocin at initiation of labour induction would have similar benefits by tipping women into labour more effectively.…”

“…There are few studies looking at concurrent oxytocin infusion with prostaglandin administration for cervical ripening and labour induction. We performed a PubMed search in all languages on 6 September 2006 using the terms ‘prostaglandins and oxytocin and labor induction and trial’ and found 408 entries, but only four entries related to concurrent use of oxytocin infusion with a prostaglandin for labour induction with intact membranes 9–12 . Three of these studies 10–12 have shown shorter induction‐to‐delivery interval with concurrent infusion of oxytocin with a prostaglandin agent at initiation of labour induction, but the largest of the four trials with 151 women did not demonstrate a significantly shorter induction‐to‐delivery interval with concurrent oxytocin infusion 9 …”

The Effect of Parity on Labor Induction with Prostaglandin E2 Analogue (Dinoprostone): An Evaluation of 2090 Cases

“…There are many studies in the literature addressing the effect of dinoprostone as a cervical ripening and labor induction agent and the findings demonstrated that cervical ripening with dinoprostone-slowrelease vaginal insert was associated with a high rate of women entering active labor [9,[11][12][13][21][22][23]. But most of these studies did not evaluate the effect of parity on the success of labor induction with dinoprostone.…”

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

“…There are 5 studies on concurrent oxytocin infusion with prostaglandin administration for cervical ripening and labor induction [4,5,6,7,8]. Three of these studies have shown a shorter induction-to-delivery interval with concurrent oxytocin infusion with a prostaglandin agent at the initiation of labor, but the other 2 studies did not demonstrate a significantly shorter induction-to-delivery interval with concurrent oxytocin infusion [4,5,6,7,8]. However, in all of these studies the concurrent oxytocin infusion period and study populations were different.…”