2017
DOI: 10.1186/s13287-016-0463-4
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Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy

Abstract: BackgroundThe administration of cisplatin is limited due to its nephrotoxic side effects, and prevention of this nephrotoxicity of cisplatin is difficult. Mesenchymal stem cell (MSC)-derived exosomes have been implicated as a novel therapeutic approach for tissue injury. In this study, we demonstrated that the pretreatment of human umbilical cord MSC-derived exosomes (hucMSC-Ex) can prevent the development of cisplatin-induced renal toxicity by activation of autophagy in vitro and in vivo.MethodsIn vitro, rat … Show more

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Cited by 122 publications
(101 citation statements)
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References 52 publications
(45 reference statements)
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“…MSC-EVs-dependent renal protection is relied on the inhibition of apoptosis, necrosis and oxidative stress in renal tubular epithelial cells as well as suppression of detrimental immune response in the kidneys (Figure 2) [69]. MSC-sourced mRNAs, miRNAs and immunosuppressive factors were mainly responsible for beneficial effects of MSC-EVs in alleviation of acute and chronic renal inflammation [69][70][71][72][73][74][75][76][77][78][79][80].…”
Section: Molecular Mechanisms Responsible For Msc-evs-based Renal Promentioning
confidence: 99%
See 1 more Smart Citation
“…MSC-EVs-dependent renal protection is relied on the inhibition of apoptosis, necrosis and oxidative stress in renal tubular epithelial cells as well as suppression of detrimental immune response in the kidneys (Figure 2) [69]. MSC-sourced mRNAs, miRNAs and immunosuppressive factors were mainly responsible for beneficial effects of MSC-EVs in alleviation of acute and chronic renal inflammation [69][70][71][72][73][74][75][76][77][78][79][80].…”
Section: Molecular Mechanisms Responsible For Msc-evs-based Renal Promentioning
confidence: 99%
“…Wang and colleagues indicated that activation of autophagy in proximal tubular epithelial cells (PTEC) was responsible for greatly improved renal function of cisplatin + MSC-EVs-treated mice [75]. They showed that beneficial effects of MSC-EVs were completely abrogated by autophagy inhibitor, 3-methyladenine.…”
Section: Figurementioning
confidence: 99%
“…The HSP60 family also includes a type II hetero-oligomeric chaperonin (TRiC/CCT), which assists in the folding of about 10% of cytosolic proteins that are not folded by other simpler chaperone systems [35]. TRiC/CCT is associated with pathogenesis of many types of cancers through modulation of TRiC client proteins such as STAT3, cyclins B and E, p53, and Von Hippel-Lindau [36][37][38][39]. TRiC/CCT regulates the folding and function of STAT3 while activation of STAT3 is a common basal property of several solid and hematologic tumors.…”
Section: Role Of Hsp60 In Cancer Development Through Regulation Of MImentioning
confidence: 99%
“…EVs release and uptake have important physiological functions, and can contribute to the development of inflammatory, malignant and infectious diseases [36,37]. EVs are increasingly recognized for their role in regulating numerous biological processes, which they carry out by transferring a variety of immune modulators such as proteins, mRNAs, microRNAs and lipids, thus shuttling selected information to recipient cells [38,39]. This process may represent an alternative approach to stem cell therapy that could help attenuate disease progression.…”
Section: Discussionmentioning
confidence: 99%