Pre‐pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review

Lieshout, Ryan J. Van; Taylor, Valerie H.; Boyle, M. H.

doi:10.1111/j.1467-789x.2010.00850.x

Cited by 170 publications

(152 citation statements)

References 52 publications

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“…Antenatal maternal obesity predicts macrosomic birth 109 , later childhood obesity and metabolic disturbance 110,111 , poorer cognitive skills and greater risk of behavioural problems during childhood 112 . Antenatal interventions to prevent these consequences appear to have limited benefits.…”

Section: Persistence Of Adolescent Assets and Risksmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

288

228

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Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today’s adolescents, the largest cohort in human history, will yield great dividends for future generations.

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Section: Persistence Of Adolescent Assets and Risksmentioning

confidence: 99%

Adolescence and the next generation

Patton

Olsson

Skirbekk

et al. 2018

Nature

288

228

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“…Over the long term, children of mothers who were already overweight or obese during pregnancy are themselves at increased risk of becoming overweight or obese [103] and of developing hypertension and diabetes mellitus type II in later life [107]. In addition, there are initial indications pointing to a link between later cognitive impairments as well as externalizing and internalizing behavioral disorders and maternal obesity during pregnancy [108][109].…”

Section: Effects Of Malnutrition and Of Excessive Weight Gain Includimentioning

confidence: 99%

“…An inadequate intake of macro-and micronutrients is not just a significant health problem in low income countries [109]. According to recent meta-analyses, pregnant women in the USA, Canada, the United Kingdom, Japan, Australia and New Zealand are ingesting too much fat and saturated fatty acids [110] while the intake of folic acid, iron, iodine, and vitamin D supplements is too low and does not match national recommendations [111].…”

Section: Effects Of Malnutrition and Of Excessive Weight Gain Includimentioning

confidence: 99%

“…According to recent meta-analyses, pregnant women in the USA, Canada, the United Kingdom, Japan, Australia and New Zealand are ingesting too much fat and saturated fatty acids [110] while the intake of folic acid, iron, iodine, and vitamin D supplements is too low and does not match national recommendations [111]. Moreover, there has been a significant increase in the number of overweight and obese women of child-bearing age worldwide [109]. The results of a perinatal survey in Germany showed that the percentage of pregnant women with a BMI of 30-40 kg/m 2 increased from 8.2 % in 1995 to 13.0 % in 2011; the percentage of women with a BMI ≥ 40 kg/m 2 even tripled to 1.8 %, while the percentage of underweight pregnant women (BMI < 18.5 kg/m 2 ) remained almost constant at 4% [33].…”

Section: Effects Of Malnutrition and Of Excessive Weight Gain Includimentioning

confidence: 99%

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Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy – A Review

Ulrich

Petermann

2016

Geburtshilfe Frauenheilkd

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!In recent decades, the understanding of the short and longer term effects of health-damaging behaviors and mental health problems in pregnant women and the underlying mechanisms of these behaviors and illnesses has significantly increased. In contrast, little is known about the factors affecting individual pregnant women which contribute to health-damaging behaviors and mental illness. The aim of this paper was therefore to summarize the current state of research into the consequences of nicotine and alcohol consumption, malnutrition, excessive weight gain or obesity, and impaired mental health (depression and anxiety) during pregnancy. In addition, the characteristics of pregnant women which increase their risk of developing such behaviors or mental disorders are described. A better knowledge of these risks should make it easier for clinicians to identify cases at risk early on and put measures of support in place. A review of the literature has shown that certain characteristics of pregnant women (e.g. her relationship with her partner, a previous history of mental illness prior to pregnancy) are associated with various healthdamaging behaviors as well as with impaired mental health. Affected women often show an accumulated psychosocial stress which was already present prior to the pregnancy and which may persist even after the birth of the child. Zusammenfassung Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy -A ReviewAuswirkungen und mögliche Prädiktoren gesundheitsschädigender Verhaltensweisen und psychischer Beeinträchtigungen in der Schwangerschaft -ein Überblick

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“…93) (23) . Others have shown a possible link between maternal obesity and adverse neurodevelopmental outcomes, including cognitive problems and attentiondeficit disorders in the baby (24) . However, the most widely investigated programming effect of maternal obesity is on offspring obesity.…”

Section: Programming Of Adverse Pregnancy Outcomementioning

confidence: 99%

The consequences of obesity and excess weight gain in pregnancy

2011

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The prevalence of obesity in pregnancy is rising exponentially; about 15–20% of pregnant women now enter pregnancy with a BMI which would define them as obese. This paper provides a review of the strong links between obesity and adverse pregnancy outcome which operate across a range of pregnancy complications. For example, obesity is associated with an increased risk of maternal mortality, gestational diabetes mellitus, thromboembolism, pre-eclampsia and postpartum haemorrhage. Obesity also complicates operative delivery; it makes operative delivery more difficult, increases complications and paradoxically increases the need for operative delivery. The risk of the majority of these complications is amplified by excess weight gain in pregnancy and increases in proportion to the degree of obesity, for example, women with extreme obesity have OR of 7·89 for gestational diabetes and 3·84 for postpartum haemorrhage compared to their lean counterparts. The consequences of maternal obesity do not stop once the baby is born. Maternal obesity programmes a variety of long-term adverse outcomes, including obesity in the offspring at adulthood. Such an effect is mediated at least in part via high birthweight; a recent study has suggested that the odds of adult obesity are two-fold greater in babies weighing more than 4 kg at birth. The mechanism by which obesity causes adverse pregnancy outcome is uncertain. This paper reviews the emerging evidence that hyperglycaemia and insulin resistance may both play a role: the links between hyperglycaemia in pregnancy and both increased birthweight and insulin resistance have been demonstrated in two large studies. Lastly, we discuss the nature and rationale for possible intervention strategies in obese pregnant women.

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Pre‐pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review

Cited by 170 publications

References 52 publications

Adolescence and the next generation

Adolescence and the next generation

Consequences and Possible Predictors of Health-damaging Behaviors and Mental Health Problems in Pregnancy – A Review

The consequences of obesity and excess weight gain in pregnancy

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