Pre-transplant ALBI Grade 3 Is Associated with Increased Mortality After Liver Transplantation

Bernardi, Nicole; Chedid, Marcio; Grezzana-Filho, T.J.M.; Chedid, Aljamir Duarte; Pinto, Marcelo Alves; Leipnitz, Ian; Prediger, João Edson; Prediger, Carolina; Backes, Ariane Nádia; Hammes, Thaís Ortiz; Guerra, Léa Teresinha; Araújo, Alexandre de; Álvares‐da‐Silva, Mário Reis; Kruel, Cléber Dario Pinto

doi:10.1007/s10620-019-5456-6

Cited by 18 publications

(13 citation statements)

References 30 publications

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“…The ALBI score is strongly associated with the degree of hepatic fibrosis, as assessed by the FIB-4 (fibrosis-4) index 81 , 82 or aspartate aminotransferase-to-platelet ratio index (APRI). 83 This observation presumably explains several reports that the ALBI score is an important risk factor for HCC development, 67 , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] particularly after sustained virologic response. [86] , [87] , [88] The best documented risk score for HCC in patients with chronic liver disease is the aMAP score 89 , 90 which combines ALBI with age, male sex and platelet count and may form the basis of a realistic risk stratification strategy.…”

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 60%

“… Bernardi et al. 78 Retrospective 301 Various Transplantation ALBI grade 3 was related to lower survival after liver transplantation. Zhang et al.…”

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 97%

“… 66 , [75] , [76] , [77] Perhaps surprisingly, it has been reported that ALBI predicts outcomes for patients undergoing liver transplantation. [78] , [79] , [80] The initial ALBI report showed no difference in survival according to pre-transplant ALBI, implying that prognosis was attributable to the function of the new liver. It is possible that, in those studies citing an association between ALBI and post-transplant survival, ALBI was acting as a measure of general peri-operative ill health.…”

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 99%

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The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda

Johnson

2022

JHEP Reports

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Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 60%

“… Bernardi et al. 78 Retrospective 301 Various Transplantation ALBI grade 3 was related to lower survival after liver transplantation. Zhang et al.…”

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 97%

Section: Beyond Hcc: Application Of the Albi Score/grade In General H...mentioning

confidence: 99%

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The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda

Johnson

2022

JHEP Reports

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“…Previous studies demonstrated that postoperative complications were related to preoperative clinical markers, including albumin, total bilirubin and ALBI scores [ 37 , 38 ]. The ALBI score was found to play an important role in evaluating the functional performance of the liver [ 39 , 40 ]. A poor grade (ALBI grade 3) was significantly associated with postoperative complications and mortality during hospitalization [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Low preoperative prealbumin predicts the prevalence of complications following liver transplantation

Liu

Jiang

et al. 2021

BMC Gastroenterol

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Background As a nutritional index, preoperative serum prealbumin highly correlates with surgical complications. However, the correlation between preoperative prealbumin and postoperative complications remains unclear in liver transplantation (LT). Methods A total of 191 patients who underwent LT between 2015 and 2019 were included in the retrospective analysis. According to a cut-off value calculated from a receiver operating characteristic (ROC) curve, the patients were divided into normal and low preoperative prealbumin groups. Univariable and multivariable logistic regression analyses were used to identify independent risk factors for postoperative complications. In addition, patients were divided into subgroups by Model for End-stage Liver Disease (MELD) score, and the association between preoperative prealbumin and postoperative complications was also assessed in each group. Results A total of 111 (58.1%) patients were included in the low prealbumin group based on a cut-off value of 120 mg/L. The area under the ROC curve (AUC) was 0.754 (95% confidence interval [CI] 0.678–0.832). Low prealbumin (95% CI 1.51–12.8, P = 0.007) was identified as a predictor for postoperative complications based on multivariable regression. In the low and normal prealbumin groups, the prevalence rates of postoperative complications were 27.5% and 8.0% (P = 0.003) in the MELD score ≤ 15 subgroup and 53.3% and 20.0% (P = 0.197) in the MELD score > 15 subgroup, respectively. Conclusions Preoperative prealbumin was associated with postoperative complications in LT, and preoperative nutritional support benefitted postoperative recovery, especially for patients with low MELD scores.

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“…Recently, some studies have proven that ALBI score and PALBI score have certain predictive values for the prognosis of liver cirrhosis, 18 - 20 hepatitis B virus (HBV)-related liver disordesr, 21 acute-on-chronic liver failure (ACLF), 22 cirrhosis-related upper gastrointestinal bleeding, 23 , 24 and liver transplantation. 25 AARC-ACLF score 26 is considered to be a newly developed simple scoring system, which depends on Asian ACLF patients. A previous study 27 showed that the AARC ACLF score was superior to other scoring systems in predicting the progression and prognosis of hospitalized patients with acute decompensated cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Prognostic Value of Existing Scoring Systems for Nosocomial Infection in Patients with Decompensated Liver Cirrhosis

Zhao¹,

Ou²,

Guo³

et al. 2023

Turk J Gastroenterol

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Background: Many scoring systems have been developed to evaluate the severity and survival of end-stage liver disorder patients. However, the conduction of these different predicting models has not been thoroughly verified in cirrhotic patients with nosocomial infections. This study ended to compare the predictive accuracy of various scoring systems. Methods: During January 2015 and January 2020, liver cirrhosis patients with nosocomial infections were involved in this study. The clinical data, laboratory findings, and demographic characteristics of patients were collected during diagnosis. Patients were followed up for at least 6 months or till death. Results: One hundred thirty-one patients meeting the criteria were enrolled and followed up for at least 6 months. The mortality rate at 30 days, 3 months, and 6 months was 23%, 35.1%, and 39.6%, respectively. The univariate analysis showed that all scoring systems indicated statistical significance between the surviving group and the non-surviving group at 6 months. Model for end-stage liver disease-Na showed excellent predictive accuracy in predicting the survival at 30 days, 3 months, 6 months, with the area under the curve of 0.807, 0.850, and 0.844, respectively. Model for end-stage liver disease-Na demonstrated sensitivities of more than 85%. In contrast, the child-turcotte-pugh and albumin-bilirubin scores showed a poorer predictive capability. Conclusion: All 5 models for end-stage liver disease-related scores (model for end-stage liver disease, model for end-stage liver disease-to-serum sodium ratio, model for end-stage liver disease-Na, model for end-stage liver disease-Delta, snd integrated model for end-stage liver disease) exhibited a reliable prediction for mortality of long-term prognosis and short-term prognosis of cirrhotic patients with nosocomial infections. Among them, the model for end-stage liver disease-Na score might be the best choice.

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Pre-transplant ALBI Grade 3 Is Associated with Increased Mortality After Liver Transplantation

Cited by 18 publications

References 30 publications

The ALBI score: From liver function in patients with HCC to a general measure of liver function

The ALBI score: From liver function in patients with HCC to a general measure of liver function

Low preoperative prealbumin predicts the prevalence of complications following liver transplantation

Evaluation of the Prognostic Value of Existing Scoring Systems for Nosocomial Infection in Patients with Decompensated Liver Cirrhosis

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