Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial

Birkeland, Eline; Gharagozlian, Sedegheh; Birkeland, Kåre I.; Valeur, Jørgen; Måge, Ingrid; Rud, Ida; Aas, Anne-Marie

doi:10.1007/s00394-020-02282-5

Cited by 139 publications

(96 citation statements)

References 59 publications

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“…The characteristics of the studies included are shown in Table 2 . While three of these studies were conducted in Italy [ 26 , 27 , 28 ], one study each was carried out in Norway [ 29 ], Japan [ 30 ], Mexico [ 22 ], UK [ 23 ], Canada [ 31 ] and China [ 13 ]. All the studies were randomised controlled trials with parallel design, except one which was a randomised cross-over study [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, there were no significant differences in alpha or beta diversity [ 31 ]. According to Birkeland et al [ 29 ], in the dietary fibre group, there was moderate changes in the faecal microbiota composition (1.5%, p = 0.045), and the effect was most prominent on operational taxonomic units (OTUs) of Bifidobacterium adolescentis, followed by OTUs of Bacteroides.…”

Section: Resultsmentioning

confidence: 99%

“…In the study by Birkeland et al [ 29 ], while the intervention (dietary fibre) group showed a significant increase in faecal concentrations of total SCFA ( p = 0.04), acetic acid ( p = 0.02), and propionic acid ( p = 0.04) as compared to control group, there was no significant difference in relation to butyric acid between the treatments ( p = 0.19) or on the overall microbial diversity [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

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The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

et al. 2020

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Background: The prevalence of type 2 diabetes is on the increase worldwide, and it represents about 90% of adults who are diagnosed with diabetes. Overweight and obesity, lifestyle, genetic predisposition and gut microbiota dysbiosis have been implicated as possible risk factors in the development of type 2 diabetes. In particular, low intake of dietary fibre and consumption of foods high in fat and sugar, which are common in western lifestyle, have been reported to contribute to the depletion of specific bacterial taxa. Therefore, it is possible that intake of high dietary fibre may alter the environment in the gut and provide the needed substrate for microbial bloom. Aim: The current review is a systematic review and meta-analysis which evaluated the role of dietary fibre in modulating gut microbiota dysbiosis in patients with type 2 diabetes. Methods: This is a systematic review and meta-analysis of randomised controlled trials which relied on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. Electronic searches were conducted using EBSCOHost with links to Health Sciences Research Databases, EMBASE and Google Scholar. The reference lists of articles were also searched for relevant studies. Searches were conducted from date of commencement of the database to 5 August 2020. The search strategy was based on the Population, Intervention, Comparator, Outcomes, Studies (PICOS) framework and involved the use of synonyms and medical subject headings (MesH). Search terms were combined with Boolean operators (OR/AND). Results: Nine studies which met the inclusion criteria were selected for the systematic review and meta-analysis, and four distinct areas were identified: the effect of dietary fibre on gut microbiota; the role of dietary fibre on short-chain fatty acids (SCFAs); glycaemic control; and adverse events. There was significant difference (p < 0.01) in the relative abundance of Bifidobacterium with a mean difference of 0.72 (95% CI, 0.56, 0.89) between the dietary fibre group compared with placebo. In relation to the meta-analysis for SCFAs, while there was significant difference (p = 0.02) between the dietary fibre group and placebo with a standardised mean difference of 0.5 (95% CI, 0.08, 0.91) regarding total SCFAs, the differences were not significant (p > 0.05) in relation to acetic acid, propionic acid and butyric acid. There was only significant improvement (p = 0.002) with respect to glycated haemoglobin with a mean difference of −0.18 (95% CI, −0.29, −0.06) between the dietary fibre group and placebo group. Differences between the two groups were not significant (p > 0.05) in relation to fasting blood glucose and homeostatic model assessment of insulin resistance (HOMA-IR). Furthermore, there were no significant differences between the two groups in subjects who reported adverse events. It is possible that the promotion of SCFA producers in greater diversity and abundance by dietary fibre in this review led to improvement in glycated haemoglobin, partly due to increased glucagon-like peptide-1 (GLP-1) production. In addition, Bifidobacterium lactis has been reported to increase glycogen synthesis, decrease expression of hepatic gluconeogenesis genes, improve translocation of glucose transport-4 and promote glucose uptake. It is also possible that the reduction in body weight of participants in the intervention group compared with control may have contributed to the observed improvement in glycated haemoglobin. Conclusion: This systematic review and meta-analysis have demonstrated that dietary fibre can significantly improve (p < 0.05) the relative abundance of Bifidobacterium, total SCFAs and glycated haemoglobin. However, dietary fibre did not appear to have significant effect (p > 0.05) on fasting blood glucose, HOMA-IR, acetic acid, propionic acid, butyric acid and adverse events.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

et al. 2020

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“…The decrease of phylum Bacteroidetes was mainly due to the poor abundance of Bacteroides in the DM group at the genus level. Bacteroides was famous for its genomic capability, which could ferment various sugars into short-chain fatty acids (SCFAs) [ 9 ]. Among SCFAs, propionic acid could reduce visceral fat.…”

Section: Discussionmentioning

confidence: 99%

The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes

Zhao

Zhang

Guo

et al. 2020

Journal of Diabetes Research

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Background. Diabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial community. We aimed to explore the alteration in composition and function of the gut microbiome in T2DM patients. Methods. A total of 137 patients with diabetes and 179 age- and gender-matched healthy controls selected from the healthy people sample center in the First Affiliated Hospital of Zhengzhou University were divided into the DM group and the Con group, respectively. We collected their venous blood for laboratory tests and stool samples for 16S rRNA sequencing. The comparison between the two groups including both composition and function of the gut microbiome is presented.Results. We found that the α-diversity of bacterial taxa in the DM group had an evident decrease compared to that in the Con group. At the phylum level, the DM group had an obvious decrease of Bacteroidetes and a marked increase of Proteobacteria, Actinobacteria, and Verrucomicrobia. At the genus level, Bacteroides and Prevotella decreased the most while Escherichia-Shigella, Lachnospiraceae_incertae_sedis, Subdoligranulum, Enterococcus, and Klebsiella had different degrees of expansion in the DM group. The ROC based on 246 optimum OTUs had very high test efficiency with an AUC of 92.25% in the training set and 90.48% in the test set. As for prediction of metabolic function, the gut microbiome of DM patients was predicted to be more active in environmental information processing and human diseases but less in metabolism. Conclusion. We observed alteration of composition and function of the gut microbiome in the DM group. These changes may provide a new treatment strategy for DM patients and new research targets.

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“…In fact, ndings concerning the effect of dietary bre intake on butyrate level are inconsistent across different studies. The intake of inulin-type fructans by patients with type 2 diabetes showed unchanged level [27], whereas inulin intake by mice showed the increasing level of butyrate in faeces, but not in plasma [28]. Alfalfa-containing diet also increased butyrate level in the caecal digesta of pigs [29] and caecal levels of mucosal genes involved in SCFA sensing and absorption [29].…”

Section: Discussionmentioning

confidence: 99%

The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

Liu¹,

Jiang²,

Chen³

et al. 2020

Preprint

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Background: Gestational intake of dietary fibre improves the parturition progress, which largely affects developmental outcomes of the offspring. Dietary fibre can alter the gut microbiome and production of symbiotic metabolites, e.g. short chain fatty acids (SCFAs). We hypothesized that the improvement of parturition progress by dietary fibre is associated with the symbiotic metabolites generated by the gut microbiome. Methods: Yorkshire sows were randomly given diet containing normal level of fibre (NDF, 16.2% dietary fibre, n = 20) or high level (HDF, 30.1%, n = 20) with other nutrients identical from days 90 of gestation to parturition. Faecal microbiome profiled with 16S amplicon sequencing, SCFAs and metabolome in the faeces and plasma around parturition were compared between the dietary groups. Correlation analysis was conducted to further explore the potential associations between specific bacterial taxa and metabolites. Results: HDF significantly improved the parturition progress, indicated by the shorter parturition duration. HDF increased abundance of the phyla Bacteroidetes and Synergistetes and multiple genera. Except for butyrate, SCFAs levels in the faeces and plasma of sows at parturition were increased in HDF group. The abundances of 15 and 12 metabolites in the faeces and plasma, respectively, markedly differ between HDF and NDF sows. These metabolites are involved in the bacterial metabolism of amino acids, bile acids, SCFAs and dietary fibre. Correlation analysis also showed associations between specific taxa (genera Cellulosilytica and Lachnoclostridia) and metabolites (acetate and isobutyrate).Conclusions: The improvement of parturition process by high fibre intake in late gestation is associated with altered gut microbiome, production of SCFAs and other metabolites, potentially serving for energy metabolism.

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Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial

Cited by 139 publications

References 59 publications

The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes

The Improvement of Parturition Progress by High Intake of Dietary Fibre in Late Gestation is Associated with the Altered Gut Microbiome and Metabolome in Sows

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