Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

Savignac, Hélène M.; Corona, Giulia; Mills, Henrietta; Chen, Li; Spencer, Jeremy P. E.; Tzortzis, George; Burnet, Philip W.J.

doi:10.1016/j.neuint.2013.10.006

Cited by 325 publications

(232 citation statements)

References 45 publications

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“…Moreover, NR1 subunit expression in the hippocampus was increased following prebiotic supplementation (Savignac et al, 2013). However, an alternative prebiotic did not alter CNS NDMA receptor expression in the frontal cortex (Savignac et al, 2015) and further studies are required to demonstrate that deliberate effects on relevant receptors can be achieved with other interventions such as probiotics.…”

Section: Microbial Regulation Of Cns Receptors Neurogenesis and Myelmentioning

confidence: 99%

Kynurenine pathway metabolism and the microbiota-gut-brain axis

et al. 2017

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Section: Microbial Regulation Of Cns Receptors Neurogenesis and Myelmentioning

confidence: 99%

Kynurenine pathway metabolism and the microbiota-gut-brain axis

et al. 2017

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“…However, after synbiotic supplementation the patient was satisfied with his sleep, and he felt more disposed and more capable of carrying out his daily activities. In fact, studies suggest that an improvement in QOL following synbiotic therapy is a credible hypothesis (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

et al. 2016

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Enfermedad renal crónica. Microbiota. Simbióticos. Diarrea. Hemodiálisis. Key words:Chronic kidney disease. Microbiota. Synbiotics. Diarrhea. Hemodialysis. ResumenIntroducción: los pacientes con enfermedad renal crónica (ERC) a menudo tienen síntomas gastrointestinales que pueden provocar desnutrición y un impacto negativo en su calidad de vida. La modulación de la microbiota intestinal puede ser una estrategia para promover la salud del huésped y la homeostasis. Caso clínico: los autores presentan un caso de diarrea crónica de etiología desconocida en un paciente en hemodiálisis (HD). Después de varias intervenciones fallidas durante un año, se realizó el tratamiento simbiótico. Los episodios de diarrea cesaron después de tres meses de la suplementación diaria y ambos parámetros bioquímicos y nutricionales mejoraron. La terapia con simbióticos promovió beneficios clínicos para este paciente. Discusión: por lo tanto, esta sencilla terapia puede ser una alternativa prometedora en la ERC y debe ser probada en estudios más amplios.Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis AbstractBackground: Chronic kidney disease (CKD) patients often have gastrointestinal symptoms which may result in malnutrition and a negative impact on their quality of life. Modulation of the gut microbiota can be a strategy to promote host health and homeostasis. Case report: The authors present a case of chronic diarrhea in a hemodialysis (HD) patient with an unknown etiology. After about one year and several failed interventions, synbiotic therapy was performed. The diarrhea episodes ceased after three months of daily supplementation and both biochemical and nutritional parameters improved. Synbyotic therapy promoted clinical benefits in this patient. Discussion: Therefore, this simple therapy may be a promising alternative in CKD and it should be tested in larger studies.

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“…BDNF regulates multiple aspects of cognitive and emotional behaviors and its expression can be modulated by prebiotic supplementation. BDNF gene expression notably increased in rats when orally administrated with prebiotics, fructooligosaccharides and galactooligosaccharides for five weeks [79].…”

Section: The Role Of Microbiota-derived Metabolitesmentioning

confidence: 99%

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

Lee¹,

Serre²

2015

JNHFS

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cell injury [6], metabolic regulation [7], GI tract development [8], innate and adaptive immune responses, and absorption of nutrients [9,10]. Alterations in microbiota composition and dysregulation of the intestinal mucosa homeostasis have been implicated in the development and progression of pathologies. This compositional change in the microbiota and/ or an abnormality in the interactions between the host and the commensal microbiota is referred to as dysbiosis. Gut microbiota dysbiosis has been linked to chronic low-grade intestinal inflammation and acute intestinal autoimmunity diseases such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) [11,12]. Abnormal microbiota composition is associated with a wide range of metabolic and behavioral disorders, such as anxiety/depression [13][14][15] [26]. GI microbiota dysbiosis might also be involved in the development and persistence of systemic disorders [27]. For example, obesity has been characterized by a decrease in overall diversity [28] and an increase in Proteobacteria abundance and in the Firmicutes to Bacteroidetes ratio [28,29] and microbiota composition is believed to influence energy balance and glucose homeostasis [30][31][32].Evidence that changes in microbiota composition are correlated with metabolic and behavioral disorders has drawn attention to a potential causal role for the microbiota in pathologies and has led to the emergence of the 'microbiota-gutbrain axis' concept [33][34][35]. The gut-brain axis is a bidirectional communication system between the GI tract and the brain [36] via hormonal, immunological, and neural signaling. Information from the GI tract and the intestinal microbiota can reach the peripheral and Central Nervous System (CNS), concurrently the brain is able to influence GI functions such as motility and secretion but also immune responses and cytokine production [36,37]. The Microbiota-Gut-Brain AxisThe gut microbiota can modulate gut-brain axis signaling via direct and indirect mechanisms. The microbiota acts via endocrine, metabolic (bacterial components and metabolites), AbstractThe human gut microbiota contains more than 100 trillion bacteria that, under normal physiological conditions, have beneficial symbiotic interactions with the host. However, a growing body of evidence has shown that alternations in the composition and diversity of the gut microbiota, or dysbiosis, can influence the development and progress of metabolic and neurological disorders. Communication between the microbiota and the brain is a bidirectional system involving endocrine, metabolic (bacterial components and metabolites), immune, and neural pathways. Gut microbiota composition influences the signals transmitted from the gut to the brain. Alternatively, the brain utilizes similar mechanisms, in particular endocrine and neural signaling, to modulate the composition of the gut bacteria. In this review, we describe the recent evidence of gut microbiota interaction with the central nervous system to influence physiological a...

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Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

Cited by 325 publications

References 45 publications

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

Gut Microbiome-Brain Communications Regulate Host Physiology and Behavior

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