Precipitants in 42 cases of erythema multiforme

Villiger, Reto; Vigier, Rodo O. von; Ramelli, Gian Paolo; Hassink, R. I.; Mg, Bianchetti

doi:10.1007/s004310051244

Cited by 42 publications

(35 citation statements)

References 13 publications

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“…10 Although no identifiable cause can be found in about 50% of EM cases, many etiologic factors have been suggested, including drugs, physical agents, x-ray therapy, pregnancy, internal malignancies, and infectious agents such as Mycoplasma and HSV. 10,11 In fact, molecular and immunologic evidence suggesting that HSV causes a subset of EM lesions has led to the distinct classification of herpes-associated erythema multiforme (HAEM). 12 Kokuba, Aurelian, and Burnett 12 sought to understand the differences between EM associated with HSV infection compared to EM secondary to medication.…”

Section: Discussionmentioning

confidence: 99%

Erythema multiforme during anti–tumor necrosis factor treatment for plaque psoriasis

Ahdout

Haley

Chiu

2010

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Erythema multiforme during anti–tumor necrosis factor treatment for plaque psoriasis

Ahdout

Haley

Chiu

2010

Journal of the American Academy of Dermatology

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“…Prompt recognition of this rare disease is important to differentiate it from other manifestations that require specific therapy. The main differential diagnosis of AHEI of young children includes HSP [6, 7]. In Table 1 the main characteristics and differences between the two diseases are outlined.…”

Section: Discussionmentioning

confidence: 99%

Methylprednisolone Therapy in Acute Hemorrhagic Edema of Infancy

Risikesan

Koppelhus

Steiniche

et al. 2014

Case Reports in Dermatological Medicine

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We present a case of an 18-month-old boy who showed severe clinical signs indicative of acute hemorrhagic edema of infancy (AHEI) with painful purpuric skin affection primarily of the face and marked edema of the ears. The histological findings were diagnostic for leukocytoclastic vasculitis and thus met the histological criteria for AHEI. Indicative of infection as causative agent for the condition were symptoms of gastroenteritis. High-dose intravenous corticosteroids led to a fast resolution of symptoms and normalization of laboratory parameters. AHEI is usually not described as being very responsive to corticosteroids. The case presented here indicates that severe cases of AHEI can be treated with high-dose intravenous corticosteroids resulting in significant relief and shortening of the symptoms. Clinical followup showed no underlying malignancy or other severe chronic systemic diseases thus confirming earlier reports that AHEI is not associated with such conditions. The differential diagnoses with AHEI are discussed.

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“…Generally, HSV-1 infections and acute diseases of the upper respiratory tract, two recognized triggers of EM, mostly of the minor type, occur in infancy and in the preschool years. On the contrary, Mycoplasma pneumoniae infections and drug reactions, also others two recognized triggers of Erythema Multiforme, mostly of the major type, are rather unusual before school age [35] .…”

Section: Herpes Associated Erythema Multiforme (Haem)mentioning

confidence: 98%

“…In this survey infections were found as a definite or at least presumptive trigger of EM minor in 71% of cases. Drugs (or immunization) implicated as triggers of EM minor played a highly suggestive causative role in 10% and a possible causative role in a further 29% of the patients [35] . Differential diagnosis for EM minor includes primary herpetic gingivostomatitis, aphthous ulcers, pemphigus vulgaris, benign mucous membrane pemphigoid, erosive lichen planus [14] and leprosy [28] .…”

Section: Differential Diagnosismentioning

confidence: 99%

Erythema Multiforme Minor: A Revision

Oliveira¹,

Zucoloto²

2008

American J. of Infectious Diseases

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Abstract:The term Erythema Multiforme (EM) includes a wide and controversial variety of clinical expressions at the present time. This study revises the EM minor characteristics according to the most important publications found in literature. Erythema Multiforme is a distinct dermatologic hypersensitivity pathology characterized by cutaneous or mucous lesions and eventually it can also involve both. In their more severe forms, they appear with occasional visceral involvements. In the EM minor only one mucous membrane is affected and usually is the oral mucosa. When occur in the skin, the lesions usually appear symmetrically in the extremities, in a target form, could be continuous or recurrent and none additional systemic involvement is present for both cases. Nowadays, many authors separate etiologically the several manifestations of the EM spectrum. However, no clinical definition is still accepted thoroughly, making more difficult the comparisons of etiological and clinical aspects, histopathological studies and therapeutic protocols. For the present work, we tried to elucidate through an extensive literature revision some historical and current aspects of EM, focusing mainly the EM minor and its frequent association to HSV (Herpes Simplex Virus), with their diagnostic characteristics and current therapeutics, to facilitate the physician understanding and to favor future researches about this disease.

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Precipitants in 42 cases of erythema multiforme

Cited by 42 publications

References 13 publications

Erythema multiforme during anti–tumor necrosis factor treatment for plaque psoriasis

Erythema multiforme during anti–tumor necrosis factor treatment for plaque psoriasis

Methylprednisolone Therapy in Acute Hemorrhagic Edema of Infancy

Erythema Multiforme Minor: A Revision

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