Precipitation of curcumin by pressure reduction of CO2-expanded acetone

Prasad, Rupanjali; Patsariya, Rahul; Dalvi, Sameer V.

doi:10.1016/j.powtec.2016.12.042

Cited by 10 publications

(10 citation statements)

References 41 publications

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“…Recently, Prasad et al . reported curcumin particle formation by PPRGEL process 26 . The mean particle size of curcumin varied between 0.4 µm and 30.8 µm and the particles had a plate-like structure.…”

Section: Resultsmentioning

confidence: 99%

“…Few studies have reported formation of curcumin particles using SC-CO 2 technology by PGSS, PPRGEL, ARISE, and SEDS processes 22–26 . PGSS technique uses CO 2 as a solute.…”

Section: Resultsmentioning

confidence: 99%

“…In PGSS process, SC-CO 2 is dissolved in tristearin/soy phosphatidylcholine/DMSO/curcumin mixture and curcumin loaded solid lipid particles are produced by micronization of that mixture 22 . PPRGEL, a similar method to PGSS, is employed to produce curcumin particles by atomization of curcumin/acetone solution into water 26 . In addition, ARISE is based on atomization of curcumin mixture into a vessel pressurized with CO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…After exploring the new opportunities offered by supercritical fluid technology, and especially the green processing by SC-CO 2 technology, there has been several efforts to decrease the size of curcumin using SC-CO 2 . So far, solid lipid particles by Particles Generated from Gas Saturated Solution (PGSS) 22 , micronization by Atomized Rapid Injection Solvent Extraction (ARISE) 23,24 , loading nanofibrous silk fibroin by Solution-Enhanced Dispersion via SC-CO 2 (SEDS) 25 , and Precipitation by Pressure Reduction of Gas-Expanded Liquids (PPRGEL) 26 have been employed to decrease the size of curcumin using SC-CO 2 . However, the difficulty in controlling the particle size, the use of organic solvents like acetone, and limited number of food-grade chemicals used during the production are still significant drawbacks of the current techniques.…”

Section: Introductionmentioning

confidence: 99%

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A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Ubeyitogullari

Ciftci

2019

Sci Rep

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Health-promoting effects of curcumin are well-known; however, curcumin has a very low bioavailability due to its crystalline structure. The main objective of this study was to develop a novel green nanoparticle formation method to generate low-crystallinity curcumin nanoparticles to enhance the bioavailability of curcumin. Nanoporous starch aerogels (NSAs) (surface area of 60 m2/g, pore size of 20 nm, density of 0.11 g/cm3, and porosity of 93%) were employed as a mold to produce curcumin nanoparticles with the help of supercritical carbon dioxide (SC-CO2). The average particle size of the curcumin nanoparticles was 66 nm. Impregnation into NSAs decreased the crystallinity of curcumin and did not create any chemical bonding between curcumin nanoparticles and the NSA matrix. The highest impregnation capacity was 224.2 mg curcumin/g NSA. Curcumin nanoparticles significantly enhanced the bioaccessibility of curcumin by 173-fold when compared to the original curcumin. The concentration of curcumin in the bioaccessible fraction was improved from 0.003 to 0.125 mg/mL by impregnation of curcumin into NSAs (42-fold). This is a novel approach to produce food grade curcumin nanoparticles with reduced crystallinity and maximize the utilization of curcumin due to increased bioaccessibility.

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Section: Resultsmentioning

confidence: 99%

“…Few studies have reported formation of curcumin particles using SC-CO 2 technology by PGSS, PPRGEL, ARISE, and SEDS processes 22–26 . PGSS technique uses CO 2 as a solute.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Ubeyitogullari

Ciftci

2019

Sci Rep

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“…Polymorphism in curcumin was first reported in 2011 . Since then, studies aiming to understand the polymorphic behavior of curcumin have sparked a lot of interest among researchers. − Curcumin exists as three different polymorphs. The stable form, Form 1, has a monoclinic structure, while the metastable forms, Form 2 and 3, are both orthorhombic with different lattice parameters.…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Polymorphic Behavior of Curcumin during Antisolvent Crystallization: Insights from Raman Spectroscopy and Molecular Modeling

Prasad

Gupta

Poornachary

et al. 2020

Crystal Growth & Design

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The focus of this work is to understand the polymorphic behavior of curcumin crystallized from two different organic solvents by liquid antisolvent (LAS) precipitation carried out in a semibatch mode. LAS precipitation of curcumin from ethanol yielded the metastable (orthorhombic) Form 3, while acetonitrile led to the precipitation of stable (monoclinic) Form 1. These polymorphic crystal structures mirrored clustering of curcumin molecules in the respective organic solutions determined using in situ Raman spectroscopy. The presence of strong CH•••O bonds in acetonitrile solution indicated interactions between curcumin molecules through the phenolic end groups. On the other hand, parallel stacking of curcumin molecules was favored in ethanol solution due to stronger solute−solvent interactions at the polar end groups. These observations are consistent with the results obtained from density function theory (DFT) calculations and molecular dynamics (MD) simulations. Accordingly, with acetonitrile interacting weakly with the solute molecules, curcumin−curcumin interactions through the phenolic ends were promoted, in turn, favoring formation of Form 1. Stronger interaction between ethanol and curcumin led to relaxation of solute molecules into parallel stacked clusters, thereby favoring Form 3. Furthermore, the solvatochromic effect of curcumin exhibited in these solvents was related to solvent-induced conformations and, in turn, nucleation of curcumin crystal polymorphs.

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Micronization and characterization of ultrafine pure and composite aspirin by CO2-expanded solution

2020

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Precipitation of curcumin by pressure reduction of CO2-expanded acetone

Cited by 10 publications

References 41 publications

A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility

Elucidating the Polymorphic Behavior of Curcumin during Antisolvent Crystallization: Insights from Raman Spectroscopy and Molecular Modeling

Micronization and characterization of ultrafine pure and composite aspirin by CO2-expanded solution

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