[1] We discuss the implementation and effectiveness of a dispersive noise multifrequency calibration scheme for Deep Space tracking. We show that the combination of two phase-coherent links at X band and Ka-band, with two separate uplink carriers, can provide an effective plasma and ionospheric noise removal, in the order of 75% of the plasma noise affecting the Ka-band link. This algorithm, which we refer to as "Dual Uplink, Dual Downlink", shows a modest loss in the radio link stability, if compared to the complete, state-of-the-art calibration achieved by a more complex radio system, which supplements the two separate uplinks and downlinks at X band and Ka-band with an additional "cross-link" (X-up/Ka-down). The calibration accuracy of these two algorithms is thoroughly compared to define their advantages and shortcomings. Finally, Cassini's multifrequency tracking data acquired in 2002 during a General Relativity solar conjunction experiment aimed at the estimation of the parametrized post Newtonian parameter were reanalyzed to assess the capability of the Dual Uplink, Dual Downlink calibration algorithm to support accurate radio science experiments.Citation: Mariotti, G. and P. Tortora (2013), Experimental validation of a dual-uplink multifrequency dispersive noise calibration scheme for Deep Space tracking,