Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model

Choi, Ji Suk; Lee, Joonbum; Lee, Yuseon; Seo, Ji‐Hun; Hong, Kwang Dae

doi:10.1039/d1tb02341a

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…Thus, ECM proteins and synthetic ECMs can be used as implant coatings to reduce the amount of inflammation, regulate protein adhesion and subsequent cytokine release, and control immunomodulation. [221][222][223] Recently, MPC, a zwitterionic polymer, was used to create an artificial ECM to mimic the components that give structure and support to cells and tissues. Subsequently, it has garnered much interest for use as a coating material, mainly for implants and devices in the biomedical field.…”

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

“…Subsequently, it has garnered much interest for use as a coating material, mainly for implants and devices in the biomedical field. [187,221,222,[224][225][226][227] Over the long-term, covalently attaching MPC to the surface of PDMS diminishes the immune response along with the thickness of the fibrous capsule and levels of inflammatory indicators. [225,226,228] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion-coated PDMS microfillers reduced the immunological response in a rat model.…”

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

“…[225,226,228] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion-coated PDMS microfillers reduced the immunological response in a rat model. [221,222] Semipermeable hydrogels have been intensively investigated as antifouling implant coverings due to their unique properties, such as high water content, ease of solute transport, and the capacity for numerous active groups for future chemical modification. [221,229] They can be used to encapsulate islets against attack from immune cells by preventing direct physical contact while allowing molecules such as reactive oxygen species, NO, and cytokines to pass freely across the hydrogel network.…”

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

“…[ 225,226,228 ] Researchers have reported that based on the inflammatory and fibrosis scores, MPC zwitterion‐coated PDMS microfillers reduced the immunological response in a rat model. [ 221,222 ]…”

Section: Strategies To Enhance the Surface Biocompatibility Of Pdms A...mentioning

confidence: 99%

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Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Sutthiwanjampa

Hong

Kim

et al. 2023

Adv Materials Inter

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Section: Wwwadvmatinterfacesdementioning

confidence: 99%

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

Section: Wwwadvmatinterfacesdementioning

confidence: 99%

Section: Strategies To Enhance the Surface Biocompatibility Of Pdms A...mentioning

confidence: 99%

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Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

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Hong

Kim

et al. 2023

Adv Materials Inter

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Enhancing the Antishrinkage and Mechanical Performances of the PBAT/PVA Foam for Environment-Friendly Packaging

Ye,

Xu,

Wang

2024

Ind. Eng. Chem. Res.

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Currently, as a biodegradable polyester, poly(butylene adipate-co-terephthalate) (PBAT) and its foamed part are widely used in the packaging field due to its excellent ductility and heat resistance. However, the low-melt strength and poor shrinkage resistance of PBAT influence the foaming behavior, decrease the mechanical performance, and weaken the shape stability, thus restricting its regular use. Herein, an environment-friendly and water-soluble poly(vinyl alcohol) (PVA), with superior mechanical properties and low cost, was introduced to fabricate the blend foam via combining thermal processing and supercritical carbon dioxide (scCO 2 ) foaming technologies. The effects of PVA content on the phase morphology and rheological behavior of the blend, as well as the cell structure and mechanical properties of the PBAT/PVA blend foam, were deeply investigated. Additionally, the incorpation of PVA and the porous structure of blend foam contributed to the soil consumption capacity, owing to PVA's better water solubility and foam's higher specific surface area. The achieved PBAT/PVA foam demonstrated a higher specific compressive strength of 1.05 × 10 4 N•m/kg, a higher mass loss ratio of 28.2%, and a lower volume shrinkage ratio of 0.7%, providing valuable insights for expanding PBAT applications and addressing disposable foam plastic pollution.

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Microfluidic-Generated Injectable Bulking Agents with Biocompatible Surfaces and Their Mid-term Outcomes in a Rat Model with Anal Sphincter Injury

Lee,

Choi,

Lee

et al. 2024

ACS Omega

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Bulking agents have gained attention as new, minimally invasive treatments for fecal incontinence. Various materials and surface treatment techniques have been extensively studied to ensure good biocompatibility and long-term stability. Despite significant improvements in biocompatibility, the nonuniform particle size of existing materials has led to other challenges, such as the induction of phagocytosis or reduction of injectability during in vivo tests. This study aimed to conduct a preclinical test of the midterm stability of bulking agents with newly formulated particles with uniform size. To this end, the particles were fabricated using microfluidics, resulting in a narrow size dispersity of less than 5% as the coefficient of variation, which is essentially distinct from conventional bulking agents. The microfluidic fabrication resulted in uniformly sized particles larger than the in vivo migratory limit of 80 μm and in a reduction in maximum injection pressure. Histological staining and microscopic observations confirmed proper positioning of the filler materials in vivo and a negligible immune response for up to 6 months, indicating successful midterm stability.

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Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model

Abstract: The use of zwitterion-coated particulate silicone as a bulking agent for the treatment of fecal incontinence was investigated in a rat model.

Cited by 3 publications

References 39 publications

Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Hydrophilic Modification Strategies to Enhance the Surface Biocompatibility of Poly(dimethylsiloxane)‐Based Biomaterials for Medical Applications

Enhancing the Antishrinkage and Mechanical Performances of the PBAT/PVA Foam for Environment-Friendly Packaging

Microfluidic-Generated Injectable Bulking Agents with Biocompatible Surfaces and Their Mid-term Outcomes in a Rat Model with Anal Sphincter Injury

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