Predicting Anatomical Urological Abnormalities in Children Who Present With Their First Urinary Tract Infection

Zanetta, Vitor C.; Rosman, Brian M.; Rowe, Courtney K.; Buonfiglio, Helena B.; Passerotti, Carlo C.; Yu, Richard N.; Nguyen, Hiep T.

doi:10.1177/0009922813485284

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Those risk factors in children are stones, indwelling catheters, and abnormalities of the genitourinary tract [ 22 ]. Anatomical or functional abnormalities allow for the prolongation of bacteruria and decreasing the clearance of invading pathogens due to poor drainage [ 23 ]. Children with posterior urethral valves (PUV) have increased risks of UTI for voiding dysfunction, elevating bladder pressure stemming and ongoing renal damage.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of uropathogen and its antibiotic resistance among children with urinary tract infection from a single center in China

Zhang,

Fang,

Zhang

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A retrospective study of uropathogen and its antibiotic resistance among children with urinary tract infection from a single center in China

Zhang,

Fang,

Zhang

et al. 2024

Heliyon

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“…Among children, major complicating factors are infection stones, indwelling catheters, and abnormalities of the genitourinary tract 22 . Anatomical or functional abnormalities allow for the prolongation of bacteruria and decreasing the clearance of invading pathogens due to poor drainage 23 . Boys with PUV have increased risks of UTI voiding dysfunction, elevating bladder pressure stemming and ongoing renal damage.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antimicrobial susceptibility pattern of urinary tract infection among hospitalized children in a single center

Zhang

Hao

et al. 2022

Preprint

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The aim of this study was to explore the prevalence and antimicrobial susceptibility pattern of UTI among hospitalized children in our center. Records were reviewed retrospectively to discern the urine culture tests and antibiotic susceptibility tests of children with UTI from January 2014 to December 2021. Consequently, a total of 840 hospitalized children with UTI were collected. The proportion of culture-positive UTI was 54.52% (458/840) with majority of the isolates being Gram-negative bacteria. There were 694 children with complicated UTI in those children. The proportion of culture-positive UTI was 397/694 (57.20%). Gram-negative bacteria mainly included Escherichia coli 121 (30.48%), Klebsiella pneumoniae 32(8.06%), Pseudomonas aeruginosa 20 (5.04%), Enterobacter cloacae 11 (2.77%) and Citrobacter 13 (3.28%). Escherichia coli isolates were highly sensitive to amikacin (95.87%), ertapenem (91.74%), nitrofurantoin (92.56%), imipenem (90.08%), and cefotetan (87.60%) and high rate of resistant were also detected to ampicillin (93.39%), cephazolin (76.03%), and ceftriaxone (73.55%). Klebsiella pneumoniae isolates showed sensitive to ertapenem (96.87%), amikacin (96.87%), imipenem (93.75%) and piperacillin-tazobactam (90.62%), while highly resistant were observed to ampicillin (96.87%), cephazolin (75.00%), and ceftazidine, ceftriaxone, aztreonam (each 62.50%). The isolated Gram-positive bacteria mainly contained Enterococcus faecalis (14.61%) and Enterococcus faecium (each 16.62%). Enterococcus faecalis were sensitive to vancomycin, penicillin-G, tigecycline, linezolid and nitrofurantoin (100%, 94.83%, 88.48%, 87.93%, 86.20, respectively) and resident to tetracycline (86.21%), quinupristin (84.48%), erythromycin (75.86%). Likewise, Enterococcus faecium were sensitive to vancomycin, linezolid, tigecycline, quinupristin (98.48%, 95.45%, 84.85% , 83.33%), while resident to ampicillin (93.94%), erythromycin (89.39%), penicillin-G (84.85%), and ciproﬂoxacin (77.27%). In addition, there were 146 children diagnosed simple UTI. The culture-positive UTI was 61/146 (41.78%). The predominant bacteria were Escherichia coli (73.77%, 45/61) followed by Enterococcus faecium and CoNS (each 6.56%). Escherichia coli were highly sensitive to ertapenem, imipenem, and cefotetan (each 100%), amikacin (95.56%) and nitrofurantoin (91.11%) and high rate of resistant were also detected to ampicillin (91.11%), and trimethoprimsulfamethoxazole (64.44%). Moreover, both UTI organisms showed a high multiple drug resistance frequency (80.98% and 77.05%). Culture and susceptibility test is vital for appropriate management of UTI in the study. Further large-scale studies are warranted to examine the generalizability of our findings.

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Signs and symptoms of developmental abnormalities of the genitourinary tract

Nogueira

Paz

2016

Jornal de Pediatria

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Predicting Anatomical Urological Abnormalities in Children Who Present With Their First Urinary Tract Infection

Abstract: Young age (≤2 years) and temperature are the best factors to predict further intervention and urological abnormalities, with a temperature value of 38.3°C being a better predictive value than the currently used 38.0°C.

Cited by 4 publications

References 23 publications

A retrospective study of uropathogen and its antibiotic resistance among children with urinary tract infection from a single center in China

A retrospective study of uropathogen and its antibiotic resistance among children with urinary tract infection from a single center in China

Prevalence and antimicrobial susceptibility pattern of urinary tract infection among hospitalized children in a single center

Signs and symptoms of developmental abnormalities of the genitourinary tract

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