Achieving life satisfaction is the hope of every person, including academicians. Based on a preliminary study, the problem of life satisfaction of Christian theological seminary lecturers is a real phenomenon that has never been studied scientifically to date. This study aims to examine the life satisfaction model of seminary lecturers in terms of religiosity, self-efficacy, social support, and perceived organizational support with the meaning of work as a mediating variable. The method used in this research is quantitatively correlational; 252 lecturers from 41 theological seminaries in East Java were participants in this research. This study used six instruments to measure each variable, and the data were analyzed using the SEM-PLS technique. Based on the R 2 value for the endogenous variables, it was found that the meaning of work had a significant positive effect of 36.8% obtained from the independent variables, while the R 2 value for the life satisfaction variable is 0.259, meaning that life satisfaction can be explained by variance of 25.9% in the independent variables. The results of the research hypothesis indicate that religiosity and self-efficacy have an indirect effect on life satisfaction with the meaning of work as a full mediator, while social support does not affect both the meaning of work and life satisfaction. This study also confirms that perceived organizational support has a direct and indirect effect on life satisfaction with the meaning of work as a partial mediator. This research result is expected to enhance efforts made by seminary leaders and the government to increase the life satisfaction of lecturers in Christian theological seminaries in East Java.