Predicting Visual Outcome After Treatment of Pituitary Adenomas With Optical Coherence Tomography

Jacob, Marc C.; Raverot, Gérald; Jouanneau, Emmanuel; Borson‐Chazot, Françoise; Perrin, Gilles; Rabilloud, Muriel; Tilikete, Caroline; Bernard, Martine; Vighetto, Alain

doi:10.1016/j.ajo.2008.07.016

Cited by 142 publications

(109 citation statements)

References 23 publications

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“…OCT in several small studies has been useful in predicting visual outcome following the treatment of pituitary adenomas [91,92]. In a study of 19 patients, a greater RNFL thickness prior to treatment increased the probability of visual recovery following treatment (17 surgical and 2 pharmacological treatments).…”

Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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Summary: Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and other neurologic disorders that affect the anterior visual pathway. Optical coherence tomography (OCT) is a non-invasive technique that allows imaging of the retinal nerve fiber layer (RNFL), a structure which is principally composed of ganglion cell axons that form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure (no other central nervous system tract has this unique arrangement) for visualizing the processes of neurodegeneration, neuroprotection and, potentially, even neuro-repair. OCT is capable of providing high-resolution reconstructions of retinal anatomy in a rapid and reproducible fashion and permits objective analysis of the RNFL (axons) as well as ganglion cells and other neurons in the macula. In a systematic OCT examination of multiple sclerosis (MS) patients, RNFL thickness and macular volumes are reduced when compared to disease-free controls.Conspicuously, these changes, which signify disorganization of retinal structural architecture, occur over time even in the absence of a history of acute demyelinating optic neuritis. RNFL axonal loss in MS is most severe in those eyes with a corresponding reduction in low-contrast letter acuity (a sensitive vision test involving the perception of gray letters on a white background) and in those patients who exhibit the greatest magnitude of brain atrophy, as measured by validated magnetic resonance imaging techniques. These unique structure-function correlations make the anterior visual pathway an ideal model for investigating the effects of standard and novel therapies that target axonal and neuronal degeneration. We provide an overview of the physics of OCT, its unique properties as a non-invasive imaging technique, and its potential applications toward understanding mechanisms of brain tissue injury in MS, other optic neuropathies, and neurologic disorders.

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Section: Compressive and Infiltrative Optic Neuropathiesmentioning

confidence: 99%

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

et al. 2011

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“…14 Using the same technique, Johansson and Lindblom noted a reduction of cpRNFL that did not correlate with the visual field defect. 15 In 19 patients, Jacob et al 16 demonstrated that cpRNFL thinning measured by stratus OCT decreased the patient's chances of recovery of initial visual field defect 3 months after treatment. Inferior cpRNFL was strongly prognostic of visual field outcome after treatment of anterior visual pathway compressive lesions.…”

Section: Eyementioning

confidence: 99%

“…The GCC includes the RNFL, retinal ganglion cell (RGC) layers, and inner plexiform layer. 13 Previous studies [14][15][16][17][18] of patients with large pituitary tumours that induce optic chiasm compression identified a diffuse loss of RNFLs, even in the absence of visual field defects, and hypothesised that pituitary tumours per se, even in the absence of a compressive effect on the chiasm, may cause reversible RGC dysfunction. Whether pituitary tumours not associated to optic chiasm compression may also induce damage in RNFL is unknown.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

Cennamo

Auriemma²,

Cardone

et al. 2015

Eye

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Purpose The aim of this prospective study was to measure the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and the ganglion cell complex (GCC) using spectral domain optical coherence tomography (SD-OCT) in a cohort of consecutive de novo patients with pituitary macroadenomas without chiasmal compression. Patients and methods Twenty-two consecutive patients with pituitary macroadenoma without chiasmal compression (16 men, 6 women, aged 45.2 ± 14.6 years, 43 eyes) entered the study between September 2011 and June 2013. Among them, 31.8% harboured a growth hormone-secreting pituitary adenoma, 27.3% a prolactin-secreting pituitary adenoma, 27.3% a corticotrophin-secreting pituitary adenoma, and 13.6% a non-secreting pituitary tumour. Eighteen subjects (nine females, nine males, mean age 36.47 ± 6.37 years; 33 eyes) without pituitary adenoma, with normal ophthalmic examination, served as controls. In both patients and controls, cpRNFL and GCC thicknesses were measured by SD-OCT. Results Patients were significantly older (P = 0.02) than controls. Best corrected visual acuity, intraocular pressure, colour fundus photography, and automatic perimetry test were within the normal range in patients and controls. Conversely, cpRNFL (P = 0.009) and GCC (Po0.0001) were significantly thinner in patients than in controls. The average GCC (r = 0.306, P = 0.046) significantly correlated with the presence of arterial hypertension. OCT parameters did not differ significantly between patients with a tumour volume above the median and those with a tumour volume below the median. Conclusion Pituitary macroadenomas, even in the absence of chiasmal compression, may induce GCC and retinal nerve fibre layer thinning. SD-OCT may have a role in the early diagnosis and management of patients with pituitary tumours.

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“…The thinner the RNFL in a patient with an intracranial lesion that compresses the optic nerve, the more atrophy has occurred and the less likely it is for visual recovery to occur after optic nerve decompression. The prognostic value of OCT in patients with lesions compressing the optic nerve has been assessed by two different groups, both of which have concluded that this noninvasive imaging technique can be used as a prognostic tool in such patients [4,5]. Indeed, the study by Jacob et al [5] concluded that in patients with pituitary adenomas compressing the anterior visual pathways, the odds of complete recovery after 3 months from the initial visual field defect was multiplied by 1.29 for each increase by 1 µm of mean RNFL, independent from age and duration of symptoms.…”

mentioning

confidence: 99%

“…The prognostic value of OCT in patients with lesions compressing the optic nerve has been assessed by two different groups, both of which have concluded that this noninvasive imaging technique can be used as a prognostic tool in such patients [4,5]. Indeed, the study by Jacob et al [5] concluded that in patients with pituitary adenomas compressing the anterior visual pathways, the odds of complete recovery after 3 months from the initial visual field defect was multiplied by 1.29 for each increase by 1 µm of mean RNFL, independent from age and duration of symptoms. I commend the authors for emphasizing that even patients with chronically poor visual function from compressive optic neuropathy can recover after decompression and suggest that RNFL thickness as measured by OCT is a better prognostic indicator of potential visual recovery in such patients than the time-honored factors of preoperative visual status and duration of visual symptoms.…”

mentioning

confidence: 99%

Predicting visual recovery following optic nerve decompression for chronic optic neuropathy

Miller

2009

Acta Neurochir

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Predicting Visual Outcome After Treatment of Pituitary Adenomas With Optical Coherence Tomography

Cited by 142 publications

References 23 publications

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression

Predicting visual recovery following optic nerve decompression for chronic optic neuropathy

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