Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume.

Eldor, Amiram; Avitzour, Malka; Or, Reuven; Hanna, R; Penchas, S

doi:10.1136/bmj.285.6339.397

Cited by 83 publications

(47 citation statements)

References 19 publications

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“…It is seen that in the situations in which thrombopoiesis increases, depending on the increase in young platelets transferred into the circulation from the bone marrow, MPV also increases (4). It is seen that in serious thrombocytopenia the low MPV becomes in correlation with bleeding episodes susceptibly (5). As expected, big platelets including denser granules carry much more biochemical, functional and metabolic abilities.…”

Section: Introductionmentioning

confidence: 63%

Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

2010

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Section: Introductionmentioning

confidence: 63%

Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

2010

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“…7,10,11 We did not observe clinical signs of bleeding (petechiae, ecchymoses, etc) in the dogs in this study, possibly because increased MPV may enhance the hemostatic potential of platelets in thrombocytopenic states. 27 In this study, platelet aggregates or clumps could not be excluded as a contributing factor to the thrombocytopenia, as peripheral blood smears were not examined. Mild to moderate platelet clumping was reported to contribute to a decrease in platelet concentration when measured by the impedance method.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia

Yılmaz

Eralp

İlçöl

2008

Veterinary Clinical Pathol

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Background: Platelets are of great importance in the pathogenesis of endotoxemia. Although thrombocytopenia is used as a diagnostic sign of endotoxemia, changes in values for platelet indices (plateletcrit [PCT], mean platelet volume [MPV], and platelet size distribution width [PDW]) in response to endotoxin are still unknown. Objective: The aim of this study was to evaluate platelet count and its relations with platelet indices in a canine model of endotoxemia. Methods: Twenty dogs were divided into 2 groups of 10 each, and treated intravenously with Escherichia coli endotoxin (1 mg/kg) or vehicle. Venous blood samples were collected before treatment (0 hour) and 0.5, 1, 2, 4, 6, 8, 12, and 24 hours after treatment. Platelet counts and indices were determined on a CELL-DYN hematology analyzer. Results: The platelet count and PCT decreased by a mean of 73% and 93%, respectively (P o.001), at 0.5 hour, and remained 70% and 85% lower than baseline values (P o.001) for 24 hours after endotoxin injection. MPV and PDW increased by a mean of 28% and 45%, respectively (P o.01), at 0.5 hour, and remained increased by 7% and 16% over baseline values for 24 hours (P o.01-.001). Platelet count correlated positively with PCT (P o.001), but correlated negatively with MPV (P o.001) and PDW (P o.01). Conclusions: Changes in platelet count and its association with platelet indices may reflect changes in platelet production and reactivity. Platelet indices have potential value in the diagnosis and monitoring of dogs and humans with endotoxemia.

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“…[26] However various studies of PIs in dengue lack uniformity, probably due to methodological issues and standardization difficulties, in measuring PIs. [4,5].…”

Section: Discussionmentioning

confidence: 99%

Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?

Khandal¹,

Raghuraman²

2017

AJCMR

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Infectious diseases including Dengue illness remains the commonest cause of hospitalization in Indian settings. It is a significant global public health problem, with 2.5 billion world's population at risk and an estimated 50 to 390 million annual infections. Clinically, dengue illness manifestation varies from asymptomatic state to severe symptomatic disease. Symptomatic disease events in turn range from self-limiting dengue fever (DF) to severe dengue. Severe dengue, manifests as; dengue hemorrhagic fever (DHF), hypovolemic shock-dengue shock syndrome (DSS) or severe organ impairment. Thrombocytopenia is a common element to both dengue fever and severe dengue; and clinicians, unfortunately, tend to 'react' to thrombocytopenia with platelet transfusions at predetermined platelet thresholds. Readily available lab parameters to guide the clinician of impending platelet recovery is needed, one such parameter gaining recent interest is Platelet Indices (PIs): mean platelet volume (MPV) and platelet distribution width (PDW). Serially observing mean platelet volume along with Platelets might be valuable, with a rising trend in MPV suggesting platelet and patient recovery.

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Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume.

Cited by 83 publications

References 19 publications

Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

Mean Platelet Volume may be Reflects the Disease Activity of Ulcerative Colitis

Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia

Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?

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