Prediction of torsional failure in 22 cadaver femora with and without simulated subtrochanteric metastatic defects: A CT scan-based finite element analysis

Spruijt, S.; Linden, J.C. van der; Dijkstra, P. D. Sander; Wiggers, Theo; Oudkerk, M.; Snijders, Chris J.; Keulen, Fred van; Verhaar, Jan A N; Weinans, Harrie; Swierstra, Bart A

doi:10.1080/17453670610046424

Cited by 29 publications

(24 citation statements)

References 25 publications

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“…Although this method is widely studied to calculate the fracture risk in osteoporosis (for example (Bessho et al, 2009;Keyak et al, 2013;Kopperdahl et al, 2013;Orwoll et al, 2009)), few groups have used it for assessing failure load in metastatic bone disease in the femur (Cheal et al, 1993;Derikx et al, 2012;Keyak et al, 2005aKeyak et al, , 2007Spruijt et al, 2006;Tanck et al, 2009). Cheal et al (1993) were one of the first to use FE modelling for this purpose.…”

Section: Mechanical Models To Assess Femoral Bone Strengthmentioning

confidence: 98%

Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease

Derikx

Tanck²

2015

Journal of Biomechanics

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Current clinical practice lacks an accurate predictor for the pathological fracture risk in metastatic bone disease, but biomechanical tools are under development to improve these predictions. In this paper we explain the limitations of currently used clinical guidelines and provide an overview of more objective and quantitative approaches that have been proposed for fracture risk assessment in metastatic bone disease. Currently, such mechanical models are as sensitive and specific as clinical guidelines, but there are a number of opportunities to further improve their predictive capacity. Hence, they are a promising tool to decrease the numbers of over- and undertreated patients.

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Section: Mechanical Models To Assess Femoral Bone Strengthmentioning

confidence: 98%

Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease

Derikx

Tanck²

2015

Journal of Biomechanics

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“…Rectangular concentrators due to defect corners were examined in [5]. These concentrators were with the right angles [5] or with rounded edges [15]. The mentioned geometric dimensions of defects do not correspond fully to cuts formed after a sectoral resection; an angular size of post-resection defects can reach 3π/2.…”

mentioning

confidence: 99%

“…This approach is currently widely used for prediction of fractures and corresponding loads as well as localization of fracture in femur under different loading conditions; important results in this area are described in [1,2,9,10,13,14]. Assessments of fracture risk and definition of a failure load for bones with metastatic lesions based on the finite-element method were carried out in [3,5,7,15,16]. In a study on prediction of fracture load and objective assessment of the failure of femur with lytic defects [11], an engineering theory of beams was used in conjunction with tomographic data on structural stiffness.…”

mentioning

confidence: 99%

“…FE simulations of femurs with rectangular-shaped defects were carried out in [5] and [15]. A maximum width of defects in these studies was assumed to be equal to 0.3 [5] and 0.25 [15] of an external diameter of the bone. Rectangular concentrators due to defect corners were examined in [5].…”

mentioning

confidence: 99%

“…Basically, FE modelling and corresponding experimental verification were carried out for femurs with metastatic lesions of round or oval shape [3,7,11,16]. FE simulations of femurs with rectangular-shaped defects were carried out in [5] and [15]. A maximum width of defects in these studies was assumed to be equal to 0.3 [5] and 0.25 [15] of an external diameter of the bone.…”

mentioning

confidence: 99%

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Formation of microcracks near surgical defect in femur: Assessment of ultimate loading conditions

Босяков¹,

Алексеев²,

Shpileuski³

et al. 2016

ZN PRz Mechanika

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A bone defect of rectangular shape in a femur is considered as a result of a surgical resection of tumor lesions. Based on finite-element calculation of J-integral near the bone defect, ultimate combinations of loads corresponding to formation of microcracks were determined. The loads corresponds to simultaneous actions of own human's weight, flexion-extension, adduction-abduction and rotation of the femur. Recommendations for the prevention of pathological fractures of the femur with the surgical defect based on the obtained results were formulated.

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Accounting for patient variability in finite element analysis of the intact and implanted hip and knee: A review

Taylor

Bryan

Galloway

2012

Numer Methods Biomed Eng

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It is becoming increasingly difficult to differentiate the performance of new joint replacement designs using available preclinical test methods. Finite element analysis is commonly used and the majority of published studies are performed on representative anatomy, assuming optimal implant placement, subjected to idealised loading conditions. There are significant differences between patients and accounting for this variability will lead to better assessment of the risk of failure. This review paper provides a comprehensive overview of the techniques available to account for patient variability. There is a brief overview of patient-specific model generation techniques, followed by a review of multisubject patient-specific studies performed on the intact and implanted femur and tibia. In particular, the challenges and limitations of manually generating models for such studies are discussed. To efficiently account for patient variability, the application of statistical shape and intensity models (SSIM) are being developed. Such models have the potential to synthetically generate thousands of representative models generated from a much smaller training set. Combined with the automation of the prosthesis implantation process, SSIM provides a potentially powerful tool for assessing the next generation of implant designs. The potential application of SSIM are discussed along with their limitations.

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Prediction of torsional failure in 22 cadaver femora with and without simulated subtrochanteric metastatic defects: A CT scan-based finite element analysis

Abstract: In the future, CT scan-based FE analysis may provide a useful tool for identification of impending pathological fractures requiring prophylactic stabilization.

Cited by 29 publications

References 25 publications

Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease

Towards clinical application of biomechanical tools for the prediction of fracture risk in metastatic bone disease

Formation of microcracks near surgical defect in femur: Assessment of ultimate loading conditions

Accounting for patient variability in finite element analysis of the intact and implanted hip and knee: A review

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