Predictive factors for lymph node metastasis in patients with poorly differentiated early gastric cancer

Lee, J. H.; Choi, Min Gew; Min, Byung‐Hoon; Noh, Jae Hyung; Sohn, Tae Sung; Bae, Jae Moon; Kim, S.

doi:10.1002/bjs.8934

Cited by 36 publications

(30 citation statements)

References 22 publications

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“…These results were in line with previous reports. 22 However, although ulceration was considered as one of the independent risk factors of LNM in several studies, 23 it was not significant in the present study. In general, the presence of an ulcer is determined by endoscopic and pathological findings in the previous studies.…”

Section: Discussionmentioning

confidence: 51%

Is It Reasonable to Treat Early Gastric Cancer with Mucosal Infiltration and Well Differentiation by Endoscopic Submucosal Resection?

Feng

Sun

et al. 2015

Journal of Gastrointestinal Surgery

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Section: Discussionmentioning

confidence: 51%

Is It Reasonable to Treat Early Gastric Cancer with Mucosal Infiltration and Well Differentiation by Endoscopic Submucosal Resection?

Feng

Sun

et al. 2015

Journal of Gastrointestinal Surgery

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“…The most common symptoms in symptomatic patients are loss of appetite and weight loss. The five-year survival rate in patients who are diagnosed at an early stage cancer is reported to be improving, reaching up to 80% [3]. In countries where gastric cancer is frequently observed and routine screening programs are implemented, such as Japan, gastric cancer is more likely to be caught earlier, providing more chance of cure if possible [4].…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Preoperative Neutrophil Lymphocyte Ratio in Determining the Stage of Gastric Tumor

et al. 2017

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BackgroundNeutrophil-lymphocyte ratio (NLR) is an indicator of the inflammatory state, and its increase has been shown to be a negative prognostic factor for many malignancies. The aim of this study was to determine whether there was a relationship between NLR and tumor aggressiveness in gastric cancer patients and to investigate the prognostic significance of NLR.Material/MethodsThe medical records of 189 patients with gastric cancer between January 2009 and January 2014 were examined for the presence of metastasis, tumor staging, tumor differentiation grade, and preoperative NLR value.ResultsOf the 189 patients, 61 were female (32.2%) and 128 were male (67.7%). Eight-eight patients had NLR values of four or higher. A comparison of the high NLR value group and the low NLR value group found no statistically significant difference for clinicopathological features of age, gender, type of operation, of degree of differentiation; differences ranged from 20.7% to 46.2%, p<0.001.ConclusionsIncrease in NLR has been associated with poor prognosis in univariate analysis and variations of this parameter have also been shown to be correlated with tumor progression. NLR values should be considered as a useful follow-up parameter.

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“…Several variables associated with LNM have been reported previously, including sex, [20] depth of invasion, [7] macroscopic type, [8] tumor size, [9] and LVI. [6] In both this cohort and Japanese series, SRC histology tends to spread more superficially instead of invading deeply.…”

Section: Discussionmentioning

confidence: 99%

A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma

et al. 2016

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Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December 2015 were retrospectively reviewed. Multivariate logistic regression analysis was used to determine the independent factors of LNM. A nomogram for predicting LNM was constructed and internally validated. Additional external validation was performed using the database from Cancer Institute Ariake Hospital in Tokyo (n = 1273). Clinical performance of the model was assessed by decision analysis of curve. The overall LNM incidence was 12.9% (33/256). The multivariate logistic model identified sex, tumor size, and LVI as covariates associated with LNM. Subsequently, a nomogram consisted of sex, tumor size, and depth of invasion was established. The model showed qualified discrimination ability both in internal validation (area under curve, 0.801; 95% confidence interval [CI], 0.729–0.873) and in external dataset (area under curve, 0.707; 95% CI, 0.657–0.758). Based on the nomogram, treatment algorithm for early gastric SRC was proposed to assist clinicians in making better decisions. We developed a nomogram predicting risk of LNM for early gastric SRC, which should be helpful for patient counseling and surgical decision-making.

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Predictive factors for lymph node metastasis in patients with poorly differentiated early gastric cancer

Abstract: In the present study 3·2 per cent of patients who were negative for all identified risk factors had lymph node metastasis. The use of endoscopic submucosal dissection should be considered carefully in the treatment of poorly differentiated early gastric cancer.

Cited by 36 publications

References 22 publications

Is It Reasonable to Treat Early Gastric Cancer with Mucosal Infiltration and Well Differentiation by Endoscopic Submucosal Resection?

Is It Reasonable to Treat Early Gastric Cancer with Mucosal Infiltration and Well Differentiation by Endoscopic Submucosal Resection?

Predictive Value of Preoperative Neutrophil Lymphocyte Ratio in Determining the Stage of Gastric Tumor

A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma

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