Predictive factors of bacterial meningitis in the patients seen in emergency departments

Morales-Casado, María Isabel; Julián-Jiménez, Agustín; Lobato-Casado, Paula; Cámara-Marín, Belén; Pérez-Matos, Julio Alberto; Martínez-Maroto, Tamara

doi:10.1016/j.eimce.2016.02.001

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…--------------------------------------------------------------------------------------------------------------------------------------------- There was a significant difference between cases and controls regarding the median of platelet count and CRP level, and the mean of HCT (Table 2). The median of serum procalcitonin level was greater among cases than controls with no significant difference (Table 3) and there was a positive correlation between CRP and serum procalcitonin ( R= 0.257), that was statistically significant (P=0.048) as seen in figure (1). As regards the outcome of the studied groups, there was significant difference between both groups (Table 4).…”

Section: Resultsmentioning

confidence: 81%

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The Role of Serum Procalcitonin in The Diagnosis and Detection of The Outcome of Acute Bacterial Meningitis in Children

2023

The Egyptian Journal of Hospital Medicine

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Background: Bacterial meningitis is a pediatric emergency that requires quick diagnosis and treatment due to its high death and morbidity rates. Clinically, bacterial meningitis and non-bacterial meningitis are frequently difficult to distinguish from each other. Aim of work: To study the role of serum procalcitonin in the diagnosis and differentiation of acute bacterial from non-bacterial reasons for meningitis, in addition to its role in the evaluation of the acute bacterial meningitis outcome. Patients and Methods: This was a case-control hospital-based prospective study carried out at the Pediatric Department, Sohag University Hospital, and fever hospitals all over Sohag Governorate for 8 months, after obtaining ethical approval. Serum procalcitonin level for cases with bacterial meningitis and controls with non-bacterial meningitis was detected by Ethylenediaminetetraacetic acid (EDTA) and immunoassay device. All participants were followed clinically and by neuroimaging 2 months after the infection. Results: There was a significant increase in CRP level among cases in comparison to controls but as regards the PCT level among cases and controls, there was no significant difference between them and there was a statistically significant positive correlation between CRP and serum procalcitonin. There was a poor outcome among cases with a significant difference in comparison to controls with a significant correlation between cases outcome and serum procalcitonin. Conclusion: Serum procalcitonin levels had no significant associations with acute bacterial meningitis and had an important role in predicting its outcome but this should be confirmed by larger and more comprehensive studies.

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Section: Resultsmentioning

confidence: 81%

“…Meningitis is one of the most typical illnesses of the central nervous system in newborns and young children, which is caused by bacterial, viral, fungal, or parasitic organisms (1) . In children, it is frequently challenging to distinguish between bacterial and nonbacterial aetiologies due to comparable clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

The Role of Serum Procalcitonin in The Diagnosis and Detection of The Outcome of Acute Bacterial Meningitis in Children

2023

The Egyptian Journal of Hospital Medicine

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“…Острые бактериальные менингиты (ОБМ) остаются актуальной проблемой инфекционной патологии во всём мире, в том числе и в странах Центральной Азии, где уровень заболеваемости достигает эпидемического порога [1][2][3]. По данным ВОЗ, ОБМ регистрируются более чем в 155 странах мира, где уровень заболеваемости различен [4][5][6][7][8]. Так, показатель заболеваемости в развитых странах в межэпидемический период ОБМ составляет от 1 до 10 случаев на 100 тыс.…”

Section: Introductionunclassified

“…Несвоевременное выявление локализованных форм нейроинфекций, представляет большую опасность для развития генерализованных форм болезни и неблагоприятных исходов у 21-50% заболевших. Носительство пневмококковой инфекции достигает 35% среди здорового населения, а 70% всех пневмоний и 25% отитов вызваны именно пневмококком, а гемофильную палочку можно выделить из носоглотки 90% здоровых людей [4,7].…”

Section: Introductionunclassified

Clinical and Epidemiological Features of the Course of Acute Bacterial Meningitis in Various Age Groups

Beregovoi

Dzholbunova

Kadyrova

2019

BSP

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The clinical and epidemiological features of the course of acute bacterial meningitis in various age groups of patients in the period from 2014 to 2018 are described. An analysis of 398 case histories of patients was performed. Patients were divided into 5 age groups. The inclusion criterion is the presence of bacterial meningitis of any etiology. Patients with serious meningitis of viral and tuberculous etiology were excluded. Statistical processing was carried out using the SPSS program (determination of compliance with Gauss law, descriptive statistics, determination of average values, relationships between disease indicators, Bonferroni correction). Risk factors were determined, the course of neuro infection in various age groups was revealed, the criteria and the timing of the diagnosis of meningitis.

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“…Recent work has highlighted the role of PCT in the diagnosis of BM. [4][5][6][7][8][9] Many studies have investigated the utility of PCT for the differential diagnosis of BM and VM: serum PCT may have diagnostic value for BM since its level has been proven to be significantly increased in most cases of BM [4][5][6] ; however, the usefulness of PCT in CSF has shown conflicting outcomes. A few studies demonstrated CSF PCT levels had a higher predictive value than serum PCT levels, 7,8 while another research reported serum PCT showed a superior diagnostic value compared with CSF PCT among suspected meningitis patients.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels

Zhang

Zhou

et al. 2018

Clin Pediatr (Phila)

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The aim of this study was to analyze and compare procalcitonin (PCT) levels in serum and cerebrospinal fluid (CSF) as tools for detecting bacterial meningitis (BM) in children. Serum and CSF PCT levels as well as albumin index (AI = CSF albumin/serum albumin × 1000) were measured from 29 BM, 25 viral meningitis (VM), and 47 non-meningitis patients. Differences between groups only for CSF PCT were significant. A stronger positive correlation between CSF PCT level and AI was observed in the BM patients ( R = 0.68, P < .001). As a predictor of BM, the area under the receiver operating characteristics curve for CSF PCT was greater than that of serum PCT (0.76 vs 0.67, P < .05) and a cutoff of ⩾0.085 ng/mL achieved 55.17% sensitivity and 95.83% specificity. High levels of CSF PCT may indicate loss of integrity of the blood-brain barrier; only CSF PCT has a diagnostic value for BM in children suspected meningitis.

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Predictive factors of bacterial meningitis in the patients seen in emergency departments

Cited by 4 publications

References 31 publications

The Role of Serum Procalcitonin in The Diagnosis and Detection of The Outcome of Acute Bacterial Meningitis in Children

The Role of Serum Procalcitonin in The Diagnosis and Detection of The Outcome of Acute Bacterial Meningitis in Children

Clinical and Epidemiological Features of the Course of Acute Bacterial Meningitis in Various Age Groups

Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels

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