Predictive Suppression of Cortical Excitability and Its Deficit in Schizophrenia

Lakatos, Péter L.; Schroeder, Charles E.; Leitman, David I.; Javitt, Daniel C.

doi:10.1523/jneurosci.0010-13.2013

Cited by 114 publications

(120 citation statements)

References 71 publications

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“…The findings support the concept of multiplexing of different cortical functions across several temporal scales to enable efficient multisite communication in the brain (1). Disturbances in large-scale network communication and low-frequency phase concentration have previously been implicated in several neuropsychiatric disorders, such as schizophrenia (43). In the future, a better understanding of large-scale network impairments might offer the possibility to individually tailor therapeutic interventions by means of frequency-specific noninvasive brain stimulation (28 Behavioral relevance of coupled delta and alpha signatures.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

106

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Conscious visual perception is proposed to arise from the selective synchronization of functionally specialized but widely distributed cortical areas. It has been suggested that different frequency bands index distinct canonical computations. Here, we probed visual perception on a fine-grained temporal scale to study the oscillatory dynamics supporting prefrontal-dependent sensory processing. We tested whether a predictive context that was embedded in a rapid visual stream modulated the perception of a subsequent near-threshold target. The rapid stream was presented either rhythmically at 10 Hz, to entrain parietooccipital alpha oscillations, or arrhythmically. We identified a 2-to 4-Hz delta signature that modulated posterior alpha activity and behavior during predictive trials. Importantly, deltamediated top-down control diminished the behavioral effects of bottom-up alpha entrainment. Simultaneous source-reconstructed EEG and cross-frequency directionality analyses revealed that this delta activity originated from prefrontal areas and modulated posterior alpha power. Taken together, this study presents converging behavioral and electrophysiological evidence for frontal deltamediated top-down control of posterior alpha activity, selectively facilitating visual perception.top-down control | directional cross-frequency coupling | prefrontal cortex | alpha oscillations | phase-amplitude coupling V isual perception is flexible, selective, and rapidly integrates sensory evidence with endogenous high-level expectations and predictions (1, 2). It has been suggested that rhythmic brain activity constitutes a key mechanism to coordinate information flow in the human cerebral cortex by transiently forming task-relevant largescale networks (1). However, it is currently unclear how contextual information is dynamically integrated to support visual perception. Numerous studies have shown that visual perception critically depends on prestimulus alpha-band (8-12 Hz) activity (3-7). The gating-by-inhibition hypothesis postulates that alpha serves as a mechanism to route information to task-relevant cortical sites (8) but might also be under top-down control (6, 7). However, it is currently unclear which cortical regions and mechanisms mediate the directed top-down control of alpha oscillations (2). It has been suggested that slow-frequency activity in the delta range (<5 Hz) might reflect a mechanism for endogenous attentional selection and predictions (9, 10). In particular, endogenous low-frequency entrainment is thought to reflect a substrate of top-down processing (11)(12)(13)(14). Importantly, endogenous entrainment does not require rhythmicity in the input stream but reflects an intrinsic mechanism to enable predictions (15). Several studies have demonstrated that visual perception cycles as a function of the alpha phase but only a few reports have demonstrated that multiple rhythms modulate behavior on a fine-grained temporal scale (5,(16)(17)(18)(19).At present, it is uncertain how different temporal scales interact t...

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Section: Discussionmentioning

confidence: 99%

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Helfrich

Huang

Wilson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

106

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“…Neural oscillations are linked to several important brain functions disturbed in schizophrenia such as attention, memory and sensory processing. 55,56 Since potassium channels play a central role in neuronal synchronization, the schizophrenia-like behavior resulting from AMIGO/Kv2.1 disruption could at least partially be accounted for by disturbed synchrony and cortical oscillations associated with schizophrenia. 56 The phosphorylation, localization and activity of Kv2.1 are shown to be coupled.…”

Section: Discussionmentioning

confidence: 99%

AMIGO-Kv2.1 Potassium Channel Complex is Associated With Schizophrenia-Related Phenotypes

Peltola

Kuja-Panula

Liuhanen

et al. 2015

SCHBUL

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The enormous variability in electrical properties of neurons is largely affected by a multitude of potassium channel subunits. Kv2.1 is a widely expressed voltage-dependent potassium channel and an important regulator of neuronal excitability. The Kv2.1 auxiliary subunit AMIGO constitutes an integral part of the Kv2.1 channel complex in brain and regulates the activity of the channel. AMIGO and Kv2.1 localize to the distinct somatodendritic clusters at the neuronal plasma membrane. Here we have created and characterized a mouse line lacking the AMIGO gene. Absence of AMIGO clearly reduced the amount of the Kv2.1 channel protein in mouse brain and altered the electrophysiological properties of neurons. These changes were accompanied by behavioral and pharmacological abnormalities reminiscent of those identified in schizophrenia. Concomitantly, we have detected an association of a rare, population-specific polymorphism of KV2.1 (KCNB1) with human schizophrenia in a genetic isolate enriched with schizophrenia. Our study demonstrates the involvement of AMIGO-Kv2.1 channel complex in schizophrenia-related behavioral domains in mice and identifies KV2.1 (KCNB1) as a strong susceptibility gene for schizophrenia spectrum disorders in humans.

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“…For concurrent digits, perceptual centers were temporally aligned and digits were distinct in their 10 and one positions (e.g., co-occurences of "35" and "37" or "81" and "21" were avoided). The onset-to-onset interval of the digits was 1.49 s, resulting in a digit presentation rate of 0.67 Hz (50). Moderately quiet, continuous white noise (signal-to-noise ratio = +10 dB) masked cue and digits.…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal dynamics of auditory attention synchronize with speech

Wöstmann

Herrmann

Maess

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

188

229

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Attention plays a fundamental role in selectively processing stimuli in our environment despite distraction. Spatial attention induces increasing and decreasing power of neural alpha oscillations (8-12 Hz) in brain regions ipsilateral and contralateral to the locus of attention, respectively. This study tested whether the hemispheric lateralization of alpha power codes not just the spatial location but also the temporal structure of the stimulus. Participants attended to spoken digits presented to one ear and ignored tightly synchronized distracting digits presented to the other ear. In the magnetoencephalogram, spatial attention induced lateralization of alpha power in parietal, but notably also in auditory cortical regions. This alpha power lateralization was not maintained steadily but fluctuated in synchrony with the speech rate and lagged the time course of low-frequency (1-5 Hz) sensory synchronization. Higher amplitude of alpha power modulation at the speech rate was predictive of a listener's enhanced performance of stream-specific speech comprehension. Our findings demonstrate that alpha power lateralization is modulated in tune with the sensory input and acts as a spatiotemporal filter controlling the read-out of sensory content.attention | neural oscillations | alpha lateralization | synchronization | speech N eural oscillations are tenable biological substrates to instantiate attentional selection of sensory information from our environment (1-3). The power of alpha oscillations (8-12 Hz) is modulated by the degree of selective attention to a behaviorally relevant stimulus (4-6). Attentive focusing to one side in auditory, visual, or tactile space leads to a relative decrease in alpha power in contralateral compared with ipsilateral sensory brain regions (7-10) and governs success of selective attention, that is, of isolating one stimulus at a specific spatial location (11-13) in the context of other distracting stimuli. In speech, however, spatial selective attention alone does not suffice for successful speech comprehension given the multiple timescales (e.g., syllable and word rate) over which speech varies. Any attentional neural mechanism that respects the temporal structure of auditory sensory inputs must therefore be dynamic over time. Here, we tested the hypothesis that spatial attention to one of two concurrent speech streams induces a lateralization of alpha power that synchronizes with the speech rate over time and enhances speech comprehension.In addition to neural alpha oscillations and their role in selective attention, low-frequency neural oscillations (delta/theta band; 1-5 Hz) in sensory cortices synchronize with the temporal structure of acoustic stimuli (14, 15) such as human speech (16,17), and this synchronization supports perception (18). Furthermore, synchronization of low-frequency neural oscillations with speech is enhanced for speech streams to which participants attend (19,20). Critically, low-frequency oscillations are commonly specified as phase-locked activity (synchroni...

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Predictive Suppression of Cortical Excitability and Its Deficit in Schizophrenia

Cited by 114 publications

References 71 publications

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception

AMIGO-Kv2.1 Potassium Channel Complex is Associated With Schizophrenia-Related Phenotypes

Spatiotemporal dynamics of auditory attention synchronize with speech

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