Predictive value of lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) in patients with oesophageal cancer undergoing concurrent chemoradiotherapy

Abstract

Background and objectivesThe survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical and readily available to predict overall survival. The aim of this study was to determine whether lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) could be potential predictors of survival in patients with advanced oesophageal squamous cell carcinoma (ESCC) undergoing concurrent chemoradiotherapy.MethodsDifferences in survival among 204 patients with advanced oesophageal cancer who underwent concurrent chemoradiotherapy were collected and analysed. Univariate and multivariate COX regression analyses were used to investigate the association between blood inflammatory markers and patient survival before treatment.ResultsUnivariate COX regression analyses showed that a history of alcohol use, neutrophil count, LMR, NLR, tumour length, and N stage were significantly associated with the survival of tumour patients receiving concurrent chemoradiotherapy. Multivariate COX regression analysis showed that NLR and LMR were predictors of outcome in tumour patients receiving chemoradiotherapy. According to receiver operating characteristic (ROC) curve analysis, the AUC of LMR and NLR was 0.734 and 0.749, and the best cutoff point for LMR and NLR was 3.03 and 2.64, respectively.ConclusionsLMR and NLR can be used to predict the survival of patients with advanced oesophageal cancer receiving concurrent chemoradiotherapy, thereby providing clinicians with suggestions for further treatment options.

<p>Nomogram to Predict Preoperative Occult Peritoneal Metastasis of Gastrointestinal Stromal Tumors (GIST) Based on Imaging and Inflammatory Indexes</p>

“…31 Studies have shown that markers of systemic inflammation, including the NLR, LMR and PLR, are closely related to the development of tumors. [32][33][34] However, in our study, we found that the increase or decrease in serum NLR, LMR, and PLR were not independent predictors of occult PM of GIST. Therefore, these markers of systemic inflammation were not included during the development of the present model.…”

Routine blood parameters are helpful for early identification of&nbsp;influenza infection in children

“…Routine blood tests are the most common tests performed in pediatric fever clinics and have been used as the primary method for identifying bacterial and viral infections. In recent years, researchers have performed an in-depth analysis of various routine blood parameters, and these parameters are useful for the early diagnosis and prognostic assessment of other diseases [6][7][8][9][10][11][12].…”

Brief review on the roles of neutrophils in cancer development

“…104 NLR is directly associated with the clinical outcome of patients with cancer, which is usually combined with lymphocyte-to-monocyte ratio for evaluation. 105 Sometimes monocyte-neutrophils ratio is also utilized, 106 whereas it is important to have an absolute NLR value for patients to evaluate cancer stage, adequate treatment, and estimate clinical outcome, which would be largely valuable information. Besides, it seems that absolute number of neutrophils might be an underline factor to select the best treatment, which might be a promising index in clinic.…”