Predictors of diabetic cardiomyopathy in asymptomatic patients with type 2 diabetes

Mitrović, Jelena; Seferović, Petar; Tesic, B. Vujisic; Petrović, Milan; Ristić, Arsen D.; Lalić, Katarina; Jotić, Aleksandra; Tešić, Milorad; Milić, Nataša; Singh, Sandra; Lalić, Nebojša

doi:10.1016/j.ijcard.2012.01.052

Cited by 13 publications

(5 citation statements)

References 15 publications

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“…Cardiovascular complications are major contributors to the heightened mortality and morbidity levels in diabetic patients, with epigenetic changes, as a consequence of environmental factors and their interactions with genetic factors, proposed to play an important role in disease susceptibility. Epigenetic mechanisms, including DNA methylation, microRNA, chromatin remodelling and histone modifications are powerful regu- lators of gene expression, with relevance to the pathophysiology of DC [90,91]. MicroRNAs are a novel group of non-coding small RNAs that co-ordinate gene activity patterns, being increasingly recognized to have a significant role in a wide array of physiological and pathophysiological processes.…”

Section: Is It Possible To Prevent Dc?mentioning

confidence: 99%

Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies

Tarquini

Pala

Brancati

et al. 2018

CMC

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Section: Is It Possible To Prevent Dc?mentioning

confidence: 99%

Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies

Tarquini

Pala

Brancati

et al. 2018

CMC

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“…In those latter papers [ 8 – 11 ], although myocardial ischemia was excluded, some patients had hypertension and the number of patients was much smaller than in former papers [ 2 – 6 ]. Cardiac echographic features may be associated with diabetes and most often with older age, male gender, higher body mass index (BMI), hypertension, renal dysfunction, or other metabolic parameters such as dyslipidemia [ 2 , 3 , 12 , 13 ]. Although several recent studies have confirmed higher prevalence and severity of heart failure in diabetic than in nondiabetic patients [ 14 – 16 ], the specificity and the importance of diabetic cardiomyopathy are still debated [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Specific Diabetic Cardiomyopathy: An Observational Retrospective Echocardiographic Study in 656 Asymptomatic Type 2 Diabetic Patients

Pham

Cosson

Nguyen

et al. 2015

International Journal of Endocrinology

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Aim. Our aim was to assess the prevalence of subclinical diabetic cardiomyopathy, occurring among diabetic patients without hypertension or coronary artery disease (CAD). Methods. 656 asymptomatic patients with type 2 diabetes for 14 ± 8 years (359 men, 59.7 ± 8.7 years old, HbA1c 8.7 ± 2.1%) and at least one cardiovascular risk factor had a cardiac echography at rest, a stress cardiac scintigraphy to screen for silent myocardial ischemia (SMI), and, in case of SMI, a coronary angiography to screen for silent CAD. Results. SMI was diagnosed in 206 patients, and 71 of them had CAD. In the 157 patients without hypertension or CAD, left ventricular hypertrophy (LVH: 24.1%) was the most frequent abnormality, followed by left ventricular dilation (8.6%), hypokinesia (5.3%), and systolic dysfunction (3.8%). SMI was independently associated with hypokinesia (odds ratio 14.7 [2.7–81.7], p < 0.01) and systolic dysfunction (OR 114.6 [1.7–7907], p < 0.01), while HbA1c (OR 1.9 [1.1–3.2], p < 0.05) and body mass index (OR 1.6 [1.1–2.4], p < 0.05) were associated with systolic dysfunction. LVH was more prevalent among hypertensive patients and hypokinesia in the patients with CAD. Conclusion. In asymptomatic type 2 diabetic patients, diabetic cardiomyopathy is highly prevalent and is predominantly characterized by LVH. SMI, obesity, and poor glycemic control contribute to structural and functional LV abnormalities.

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“…Hyperglycemia is the key initiator of cardiac‐dysfunction associated with DM by activation and destroying the regulation of several metabolic pathways (Seferovic Mitrovic et al, ). Modulation in the levels of insulin‐like growth factor I (IGFI) is one of the critical conditions observed during the pathogenesis of DM (Thrailkill, ).…”

Section: Introductionmentioning

confidence: 99%

Deep sea minerals prolong life span of streptozotocin‐induced diabetic rats by compensatory augmentation of the IGF‐I‐survival signaling and inhibition of apoptosis

Liao

Shibu

Kuo

et al. 2015

Environmental Toxicology

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Consumption of deep sea minerals (DSM), such as magnesium, calcium, and potassium, is known to reduce hypercholesterolemia-induced myocardial hypertrophy and cardiac-apoptosis and provide protection against cardiovascular diseases. Heart diseases develop as a lethal complication among diabetic patients usually due to hyperglycemia-induced cardiac-apoptosis that causes severe cardiac-damages, heart failure, and reduced life expectancy. In this study, we investigated the potential of DSM and its related cardio-protection to increase the life expectancy in diabetic rats. In this study, a heart failure rat model was developed by using streptozotocin (65 mg kg(-1) ) IP injection. Different doses of DSM-1× (37 mg kg(-1) day(-1) ), 2× (74 mg kg(-1) day(-1) ) and 3× (111 mg kg(-1) day(-1) ), were administered to the rats through gavages for 4 weeks. The positive effects of DSM on the survival rate of diabetes rats were determined with respect to the corresponding effects of MgSO4 . Further, to understand the mechanism by which DSM enhances the survival of diabetic rats, their potential to regulate cardiac-apoptosis and control cardiac-dysfunction were examined. Echocardiogram, tissue staining, TUNEL assay, and Western blotting assay were used to investigate modulations in the myocardial contractile function and related signaling protein expression. The results showed that DSM regulate apoptosis and complement the cardiomyocyte proliferation by enhancing survival mechanisms. Moreover DSM significantly reduced the mortality rate and enhanced the survival rate of diabetic rats. Experimental results show that DSM administration can be an effective strategy to improve the life expectancy of diabetic subjects by improving cardiac-cell proliferation and by controlling cardiac-apoptosis and associated cardiac-dysfunction. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 769-781, 2016.

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Predictors of diabetic cardiomyopathy in asymptomatic patients with type 2 diabetes

Cited by 13 publications

References 15 publications

Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies

Clinical Approach to Diabetic Cardiomyopathy: A Review of Human Studies

Evidence for a Specific Diabetic Cardiomyopathy: An Observational Retrospective Echocardiographic Study in 656 Asymptomatic Type 2 Diabetic Patients

Deep sea minerals prolong life span of streptozotocin‐induced diabetic rats by compensatory augmentation of the IGF‐I‐survival signaling and inhibition of apoptosis

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