Background: World health organization (WHO) recommended all mothers should be supported to initiate breastfeeding as soon as possible after birth within the first hour. This study examined the determinants of early initiation of breastfeeding in Ethiopia by using data from 2019 Ethiopia mini demographic and health survey (EMDHS)..Methods: The data for this study was extracted from 2019 EMDHS. A total of 3752 children born during the last 24 months at the time of survey were included for analysis from the nine regional states and two city administrations. Descriptive statistics was used to identify the proportion of children who had early initiation of breastfeeding (EIBF) after which multivariable logistic regression analysis was carried out to determine the predictors of EIBF. Results were presented using frequencies, percentages, p-value, crude and adjusted odds ratios. Statistical significance was declared at p <0.05 for the multivariable logistic regression analysis .Result: The prevalence of Early Initiation of Breastfeeding (EIBF) in Ethiopia was remarked to be 73.7% (n = 2767). Place of delivery [AOR =1.65, 95% CI: 1.39, 1.96] mother who deliveries at health facility had higher odds to practice early breast-feeding than those who deliveries at home, mode of delivery [ AOR = 3.94, 95% CI: 2.99, 5.17] mother who had deliveries by vaginal had 3.9 times higher odds to practice early breast-feeding compared with cesarian section and parity [ AOR = 1.57, 95% CI: 1.23, 2.00] mother who had more than five children had higher odds to practice early breastfeeding compared with first time babies. In addition, early breast-feeding initiation was also associated with region where mothers residing particularly in regions such as Oromia [AOR = 1.78, 95% CI: 1.26, 2.53] had higher odds to practice early breast feeding as compared with mothers residing in Tigray.Conclusions: The overall prevalence of EIBF was determined to be 73.7%. EIBF in Ethiopia was found to be significantly associated with place of delivery, mode of delivery, parity and region. Focus should be given to expand institutional delivery and increase awareness of mothers with their first delivery .