Predictors of Epilepsy in Children With Cerebrovascular Disease

Ranzan, Josiane; Riesgo, Rudimar dos Santos

doi:10.1177/0883073812464270

Cited by 22 publications

(25 citation statements)

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“…Morais et al (5) and Yang et al (14) found a significant association between late post-stroke seizures and epilepsy in children after ischemic stroke similar to our study. These studies agree that late post-stroke seizure was a risk factor for post-stroke epilepsy.…”

Section: Epilepsysupporting

confidence: 80%

“…These similar pathophysiologic mechanisms are cellular biochemical dysfunction for early post-stroke seizures and epileptogenic gliotic scarring for late post-stroke seizures (15) . This high risk of post-stroke epilepsy has been also observed in the cases with late post-stroke seizures investigated in other studies (3,5,14) and furthermore this risk is higher than that reported for the general population experiencing their first unprovoked seizures (16) . Therefore, Dhanuka et al (17) also made a conclusion that early post-stroke seizures were rather common, did not recur and could not be treated with AEDs.…”

Section: Epilepsymentioning

confidence: 69%

“…Kopyta et al (12) described strokes in 26% of their 78 patients. In other studies, Incecik et al (5) and Morais et al (13) reported seizures in 35% and 64.6% of children, respectively. In our study, post-stroke epilepsy developed in only 16.7% of the patients.…”

Section: Epilepsymentioning

confidence: 99%

“…Lee et al (3) observed seizures in 41.4%, and epilepsy in 22.3% of children with stroke. Morais et al (5) reported that 29.2% of their patients developed post-stroke epilepsy. These discrepancies in the frequency of post-stroke epilepsy exist because different groups of children, and different populations have been investigated in each study.…”

Section: Epilepsymentioning

confidence: 99%

“…The incidence of post-stroke seizures in children is known to be high (4,5) . There have been reports about the incidence of seizures after stroke in adults (6) , but there are few studies concerning seizures and epilepsy occurring after ischemic stroke in children (5,(7)(8)(9) . Therefore, we conducted a retrospective study to identify the prevalence of seizures and epilepsy and risk factors of developing epilepsy in children with ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for epilepsy after ischemic stroke in children

İncecik¹,

Hergüner²,

Beşen³

2017

BUCH

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Objective: We performed this study to determine the incidence of seizures and poststroke epilepsy and risk factors of post-stroke epilepsy after childhood ischemic stroke. Methods: In this study, we retrospectively analyzed data from children who had ischemic stroke. Results: Of the one hundred and two children, mean age of stroke onset was 67.32± 25.48 months (1-180 months). There were 56 (54.9%) boys and 46 (45.1%) girls in the study . Of the 102 patients, 39 (38.2%) had seizures. Twenty seven (69.2%) had earlyonset post-stroke seizures, and 12 (30.8%) had late-onset post-stroke seizures. Epilepsy were detected in 17 (16.7%) of the patients. Eight of them had early-onset and nine had late-onset post-stroke seizures. We found that cortical involvement and late onset post-stroke seizure are predictors of the development of post-stroke epilepsy. Conclusions: Post-stroke seizures and epilepsy in children are common. Therefore, further studies are needed to describe risk factors for the development of post-stroke epilepsy in this population. Keywords:Ischemic stroke, post-stroke epilepsy, risk factors, children ÖZ Amaç: Bu çalışma, çocukluk çağı iskemik inme sonrasında nöbet, epilepsi ve epilepsi insidansı ile risk faktörlerinin saptanması için yapıldı. Yöntem: Çalışmada, iskemik inme geçiren çocukların verileri retrospektif olarak analiz edildi. Bulgular: İskemik inme geçiren 102 hastanın yaş ortalaması 67,32± 25,48 ay (1-180 ay) idi. Elli altısı (%54,9) erkek ve 46'sı ise (%45,1) kız idi. Yüz iki hastanın, 39'u (%38,2) nöbet geçirmişti. Yirmi yedi (%69,2) hastanın nöbeti erken başlangıçlı iken, 12 (%30,8) hastanın nöbeti geç başlangıçlıydı. Hastaların 17'sinde (%16,7) epilepsi gelişmişti. Bunların 8'i erken başlangıçlı nöbeti olan hastayken, 9'u ise geç başlangıç-lı nöbeti olan hastalardı. Lezyonun lokalizasyonu ve nöbet başlama zamanı epilepsi için risk faktörü saptandı. Sonuç: İnme sonrası nöbetler ve epilepsi çocuklarda sık görülür. Bu nedenle, bu populasyonda, inme sonrası epilepsi gelişme riskini saptamak için daha fazla çalışma-ya gereksinim vardır.

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Section: Epilepsysupporting

confidence: 80%

Section: Epilepsymentioning

confidence: 69%

Section: Epilepsymentioning

confidence: 99%

Section: Epilepsymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors for epilepsy after ischemic stroke in children

İncecik¹,

Hergüner²,

Beşen³

2017

BUCH

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Outcome and recurrence 1 year after pediatric arterial ischemic stroke in a population‐based cohort

Mallick

Ganesan

Kirkham

et al. 2016

Annals of Neurology

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Outcome and recurrence one year after paediatric arterial ischaemic stroke in a population-based cohort Arterial ischaemic stroke (AIS) is an important cause of acquired brain injury in children. Few prospective population-based studies of childhood AIS have been completed. We aimed to investigate the outcome of childhood AIS 12 months after the event in a population-based cohort. Methods:Children aged 29 days to less than 16 years with radiologically confirmed AIS occurring over a 1-year period residing in southern England (population 5.99 million children) were eligible for inclusion.Outcome was assessed during a home-visit using the Paediatric Stroke Outcome Measure (PSOM).Parental impressions of recovery were assessed using the Paediatric Stroke Recurrence and Recovery Questionnaire (RRQ). PSOM score was estimated via telephone interview or clinician interview whenever home-visit was not possible. Results:96 children with AIS were identified. 2 children were lost to follow-up. 9/94 (10%) of children died before the 12-month follow-up. One child had an AIS recurrence. PSOM scores were available for 78 of 85 living children at follow-up. 39/78 (50%) had a good outcome (total PSOM score <1) and 39/78 (50%) had a poor outcome. Seizures at onset of AIS were associated with a poor outcome (Odds Ratio 3.5 95% CI 1.16-10.6). 28/73 (38%) children were judged by their carers to have fully recovered. 10/84 (12%) of children had recurrent seizures and 17/84 (20%) reported recurrent headaches. Interpretation:AIS carries a significant risk of mortality and long-term neurological deficit. However, the rates of mortality, recurrence and neurological impairment were markedly lower in this study than previously published figures in the UK.

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