Predictors of hemoglobin in Danish blood donors: results from the Danish Blood Donor Study

Abstract

As ferritin was the strongest predictor of Hb, this study supports the implementation of regular ferritin measurement as a method of risk assessment among blood donors.

Low‐grade inflammation is associated with lower haemoglobin levels in healthy individuals: results from the Danish blood donor study

“…Hb levels were significantly higher in smokers compared with non‐smokers (0·18 m m , 95% CI: 0·15–0·22) as described previously , and multivariable linear models showed significant interaction between smoking and LGI ( P < 0·001). Models were therefore stratified for current smoking status.…”

“…Among non‐smokers, LGI was negatively correlated with Hb levels (0·08 m m lower [0·12 g/dl], 95% CI: −0·11–0·05) and was associated with an increased risk of having Hb levels below the 10th percentile (OR = 1·22, 95% CI: 1·05 –1·43). Low ferritin was the strongest predictor of Hb (0·29 m m lower [0·42 g/dl], 95% CI: ‐0·31–0·26) and of risk of low Hb (OR = 2·48, 95% CI: 2·17–2·83), as also found in previous analyses without the inclusion of LGI ; however, the effect of LGI was independent of the effect of ferritin. These results were unchanged when ferritin levels were included in the analysis as a continuous variable instead of the low‐ferritin cut‐off.…”

“…We also repeated the regression analysis using ferritin level as a continuous variable. In previous analyses of predictors of Hb, we found no consistently statistically significant associations between Hb levels and dietary factors or alcohol consumption . Therefore, these factors were omitted from the models presented in the current study.…”

“…BMI was found to be positively correlated with Hb and to be associated with reduced risk of having Hb below the 10th percentile in men, while high physical activity during leisure correlated negatively with Hb, and was associated with increased risk of having a Hb level below the 10th percentile.…”

“…hsCRP and ferritin levels were measured in thawed EDTA anticoagulated plasma samples using a commercially available assay on an automated system (Ortho Vitros 5600, Ortho Clinical Diagnostics, Rochester, NY, USA) validated as previously described . The hsCRP detection limit was 0·1 mg/l.…”