Predictors of Patient Response to Antibiotic Therapy for the Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Multicenter Clinical Trial

Nickel, J. Curtis; Downey, Joe; Johnston, Brenda; Clark, Janet

doi:10.1016/s0022-5347(05)66344-6

Cited by 131 publications

(55 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, a few randomized, placebo-controlled studies showed significant improvement in 50% of CP patients receiving quinolone treatment. Antibiotic treatment was especially effective for patients who had developed CP within the past 4 weeks and had not yet received antibiotic treatment; of these patients, 75% showed signs of relief [12][13][14]. Similar results were also observed in the current study, in which 271 (72.8%) patients used antibiotics; of these, 215 (79.3%) perceived the treatment as effective or very effective.…”

Section: Discussionsupporting

confidence: 83%

Treatment of chronic prostatitis in Chinese men

Liang¹,

Li²,

Wang³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

The aim of this study is to assess the status of treatment of chronic prostatitis (CP) in Chinese men. A population-based cross-sectional survey was performed, in which 15 000 men aged between 15 and 60 years were randomly selected to receive a questionnaire designed to assess National Institutes of Health Chronic Prostatitis Symptoms Index (NIH-CPSI) status, therapeutic efficacy and 28 other items. A total of 12 743 men (84.95%) completed the questionnaire, of whom 1 071 (8.4%) were identified as having prostatitis-like symptoms and 517 (4.5%) were diagnosed with CP according to NIH-CPSI criteria and prostatitis-like symptomatology. Of the CP patients, 372 (65%) underwent long-term routine treatment 12 times per year. Additionally, 217 (72.8%) patients received antibiotic therapy and 215 (79.3%) men showed therapeutic effects. The treatment cost USD 1 151 (8 059 yuan) per person per year on average. Most CP patients received routine treatment, in most cases with antibiotics. Treatment was costly and most CP patients were not satisfied with its effectiveness. Antibacterial treatment might have been effective primarily in patients with bacterial disease.

show abstract

Section: Discussionsupporting

confidence: 83%

Treatment of chronic prostatitis in Chinese men

Liang¹,

Li²,

Wang³

et al. 2009

Asian J Androl

View full text Add to dashboard Cite

show abstract

“…NIH-CPSI responders were defined as patients who had experienced a 25% and/or a 6-point decrease (6-point responders) in the total NIH-CPSI score from the baseline values. 16,17 A 5% level of significance was used for all statistical testing, and the statistical analyses were performed using a commercially available analysis program, SPSS (SPSS Inc., Chicago, IL, USA).…”

Section: Discussionmentioning

confidence: 99%

More effects of extracorporeal magnetic innervation and terazosin therapy than terazosin therapy alone for non-inflammatory chronic pelvic pain syndrome: a pilot study

Paick

2006

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The objective of this study was to evaluate whether extracorporeal magnetic innervation (ExMI) combined with a-blocker therapy is more effective than a-blocker monotherapy for patients with non-inflammatory chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS), category IIIB. Patients were randomized to either terazosin monotherapy (group 1, n ¼ 21) or terazosin combined with ExMI therapy (group 2, n ¼ 19). Patients in group 2 had 12 treatment sessions of ExMI twice a week during 6 weeks. None of the patients experienced any side effects from treatment. The changes in each domain of the National Institutes of Health (NIH)-Chronic Prostatitis Symptom Index (CPSI) measured on week 6 were not significantly different between the groups. However, the difference (median, 25-75th percentiles) between the two groups in total NIH-CPSI scores was À4 (À11.5, À2) for group 1 and À12 (À17.3, À2.3) for group 2, respectively (P ¼ 0.047). At 6 weeks, 47.6% (10 of 21) of group 1 had a 425% decrease in total NIH-CPSI compared with 78.9% (15 of 19) of group 2 (P ¼ 0.041). Also, more patients in group 2 (78.9%) were rated as responders with a 6-point decrease in NIH-CPSI compared with group 1 (47.6%) (P ¼ 0.041). The early results suggest that ExMI combined with a-blocker therapy has better effect than a-blocker monotherapy for the treatment of CP/CPPS.

show abstract

“…Antibiotics are largely ineffective in the treatment of CP/ CPPS as the chronic nature of the syndrome is thought not to be completely attributable to an ongoing active or latent bacterial infection (43)(44)(45). Despite this, up to almost 80% of CP/CPPS patients receive antibiotics as treatment at some point during their disease course, more than 7 times that of non-CP/CPPS patients, and many receive multiple rounds of antibiotics despite lack of efficacy (46).…”

Section: Treatment Approaches To Cp/cppsmentioning

confidence: 99%