Predictors of postoperative morbidity after cytoreduction for advanced ovarian cancer: Analysis and management of complications in upper abdominal surgery

Panici, Pierluigi Benedetti; Donato, Violante Di; Fischetti, Margherita; Casorelli, Assunta; Perniola, Giorgia; Musella, Angela; Marchetti, Cláudia; Palaia, Innocenza; Berloco, P.B.; Muzii, Ludovico

doi:10.1016/j.ygyno.2015.03.043

Cited by 75 publications

(64 citation statements)

References 36 publications

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“…Regarding time interval between surgery and the initiation of adjuvant chemotherapy in PDS, Benedetti Panici et al 11 concluded that there were no differences between patients with or without postoperative complications. In our study, occurrences of major complications in the general group and in the PDS group were associated with ACD.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery

Castro

Reis

Cintra

et al. 2018

Int J Gynecol Cancer

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Section: Discussionmentioning

confidence: 99%

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery

Castro

Reis

Cintra

et al. 2018

Int J Gynecol Cancer

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“…Splenic hilum metastasis is not rare in cases with metastasis in the left upper quadrant of the abdomen. As pancreatectomy and splenectomy can significantly increase postoperative morbidity [10] and because the associated complications can cause serious and even fatal consequences [1112], the vast majority of gynecologic surgeons choose to leave these metastatic tumors alone. In such cases, optimal cytoreductive surgery is impossible.…”

Section: Discussionmentioning

confidence: 99%

Distal pancreatectomy with splenectomy for the management of splenic hilum metastasis in cytoreductive surgery of epithelial ovarian cancer

Xiang

et al. 2016

J Gynecol Oncol

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ObjectiveDistal pancreatectomy with splenectomy may be required for optimal cytoreductive surgery in patients with epithelial ovarian cancer (EOC) metastasized to splenic hilum. This study evaluates the morbidity and treatment outcomes of the uncommon procedure in the management of advanced or recurrent EOC.MethodsThis study recruited 18 patients who underwent distal pancreatectomy with splenectomy during cytoreductive surgery of EOC. Their clinicopathological characteristics and follow-up data were retrospectively analyzed.ResultsAll tumors were confirmed as high-grade serous carcinomas. The median diameter of metastatic tumors located in splenic hilum was 3.5 cm (range, 1 to 10 cm). Optimal cytoreduction was achieved in all patients. Eight patients (44.4%) suffered from postoperative complications. The morbidity associated with distal pancreatectomy and splenectomy included pancreatic leakage (22.2%), encapsulated effusion in the left upper quadrant (11.1%), intra-abdominal infection (11.1%), pleural effusion with or without pulmonary atelectasis (11.1%), intestinal obstruction (5.6%), pneumonia (5.6%), postoperative hemorrhage (5.6%), and pancreatic pseudocyst (5.6%). There was no perioperative mortality. The majority of complications were treated successfully with conservative management. During the median follow-up duration of 25 months, nine patients experienced recurrence, and three patients died of the disease. The 2-year progression-free survival and overall survival were 40.2% and 84.8%, respectively.ConclusionThe inclusion of distal pancreatectomy with splenectomy as part of cytoreduction for the management of ovarian cancer was associated with high morbidity; however, the majority of complications could be managed with conservative therapy.

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“…5 The postoperative hospital stay is correlated with the number of surgical procedures performed. 6 So, the hospital and surgeon volumes must be merged with outcome, for example, complete surgical resection and complications that must also be recorded.…”

Section: Specialized Multidisciplinary Decision Makingmentioning

confidence: 99%

European Society of Gynaecological Oncology (ESGO) Guidelines for Ovarian Cancer Surgery

Querleu

Planchamp

Chiva

et al. 2017

Int J Gynecol Cancer

146

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MethodsThe European Society of Gynaecological Oncology council nominated an international multidisciplinary development group made of practicing clinicians who have demonstrated leadership and interest in the care of ovarian cancer (20 experts across Europe). To ensure that the statements are evidence based, the current literature identified from a systematic search has been reviewed and critically appraised. In the absence of any clear scientific evidence, judgment was based on the professional experience and consensus of the development group (expert agreement). The guidelines are thus based on the best available evidence and expert agreement. Before publication, the guidelines were reviewed by 66 international reviewers independent from the development group including patients representatives.ResultsThe guidelines cover preoperative workup, specialized multidisciplinary decision making, and surgical management of diagnosed epithelial ovarian, fallopian tube, and peritoneal cancers. The guidelines are also illustrated by algorithms.

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Predictors of postoperative morbidity after cytoreduction for advanced ovarian cancer: Analysis and management of complications in upper abdominal surgery

Cited by 75 publications

References 36 publications

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery

Distal pancreatectomy with splenectomy for the management of splenic hilum metastasis in cytoreductive surgery of epithelial ovarian cancer

European Society of Gynaecological Oncology (ESGO) Guidelines for Ovarian Cancer Surgery

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