Predictors of severe hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency following exposure to oxidant stresses

Al‐Sweedan, Suleimman; Jdaitawi, Hussein; Khriesat, Wadah; Khader, Yousef; Al-Rimawi, Hala S.

doi:10.1016/s1658-3876(09)50025-8

Cited by 15 publications

(18 citation statements)

References 17 publications

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“…However, in prospective studies which focussed on safety, the estimated risk of severe adverse effects (severe anaemia, haemoglobinuric renal failure) was three orders of magnitude higher: 3.9 per thousand [39]. Although this figure still sounds reassuring at a population level it is important to emphasize that this risk is borne entirely by the sub-group of individuals who are G6PD deficient, all of whom will haemolyse with currently recommended primaquine doses to an extent determined by the severity of their enzyme deficiency [42,43]. These data also underscore the important difference in the safety of a single dose of primaquine versus continuous administration.…”

Section: Introductionmentioning

confidence: 99%

“…Naturally the clinical consequences of drug-induced AHA depend to a considerable extent on clinical status when the drug is administered, and particularly on pre-existing anaemia [34,42,43,46,48]. Thus, the risk is markedly different in healthy adults, such as those who were given primaquine experimentally, or soldiers who were given primaquine as anti-malarial prophylaxis, compared to children with acute malaria in endemic areas who are often already anaemic.…”

Section: Introductionmentioning

confidence: 99%

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Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

White

Qiao

Gao

et al. 2012

Malar J

120

147

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In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg; 45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

White

Qiao

Gao

et al. 2012

Malar J

120

147

View full text Add to dashboard Cite

show abstract

“…G6PD deficiency is not only the most common red blood cell enzymopathy but also represents the most common of all clinically significant enzyme defects of human biology as a whole [16]. G6PD deficiency constitutes a significant public health problem in the Middle East [17,18].…”

Section: Discussionmentioning

confidence: 99%

A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East

Al-Imam¹

2018

Preprint

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BACKGROUND G6PD deficiency is an inherited an X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain conditions. METHODS Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping. RESULTS Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis. CONCLUSION This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.

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“…G6PD deficiency is not only the most common red blood cell enzymopathy but also represents the most common of all clinically significant enzyme defects in human biology. 16 G6PD deficiency constitutes a significant public health problem in the Middle East. 17,18 The highest incidence of G6PD deficiency has been described in Sardinia.…”

Section: Discussionmentioning

confidence: 99%

Digital epidemiology and geographic mapping of G6PD deficiency: retrospective analytic of trends database existing on the surface web

Al-Imam

2018

Asian J Med Sci

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited X-linked recessive condition in which the body does not synthesise a sufficient quantity of the G6PD enzyme. Hemolytic anaemic episodes occur following exposure to some medications, foods, or even infections in G6PD-deficient individuals.Aims and Objectives: To assess the digital epidemiology as well as the geographic mapping of G6PD deficiency in the world including countries of the Mediterranean basin.Materials and Methods: This study is primarily based on a digital epidemiological analysis and geographic mapping based on data retrieved from Google Trends database, a very large database, existing on the surface web. A retrospective analysis was carried out for the period from the 22nd of March 2015 to the 24th of January 2016. Trends data will also be contrasted with a collateral data set of a cross-sectional analytic for the same period which was conducted based on the exploration of cases of G6PD deficiency admitted to Jordan University Hospital.Results: Concerning geographic mapping, countries of the Basin of the Mediterranean Sea and the Arabian Gulf accounted for one-third of the entire geographic map at 15.66% and 18.18% respectively. Countries of the Mediterranean basin included Jordan, Italy, Lebanon, Israel, Egypt, Greece, Syria, Cyprus, Tunisia, Algeria, and Morocco. Contributing countries surrounding the Arabian Gulf included Kuwait, Kingdom of Saudi Arabia, Bahrain, Iran, United Arab Emirates, Qatar, and Iraq. The Hashemite Kingdom of Jordan contributed to 2.78% of the global map which accounted for 17.74% of the entire Mediterranean basin. Concerning digital epidemiology, the prevalence was recorded as highest during May 2015 (12.10%), August 2015 (11.17%), and November 2015 (11.28%). Concerning the percentile contribution of monthly records, data were in harmony for those cases admitted to hospital and signals recorded via Google Trends. Both datasets averaged a percentile contribution of approximately 9% per month.Conclusion: This study is the first inferential research on G6PD deficiency based on data from a trends database and parallel data from Jordan University Hospital. Ambitious future research should deploy the use of machine learning for real-time and predictive analytics which will provide an excellent value for public health services and epidemiological studies.Asian Journal of Medical Sciences Vol.9(5) 2018 57-61

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Predictors of severe hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency following exposure to oxidant stresses

Abstract: Severe hemolysis can be predicted during hemolytic episodes in children with low G6PD by young age, male gender, a negative family history of G6PD deficiency, the presence of fever and vomiting and a high ALP.

Cited by 15 publications

References 17 publications

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common

A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East

Digital epidemiology and geographic mapping of G6PD deficiency: retrospective analytic of trends database existing on the surface web

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