Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan

Oodate, Mitsuru; Kimura, Kouji; Banno, Hirotsugu; Yokoyama, Satoru; Jin, Wei; Wachino, Jun-ichi; Hasegawa, Yoshinori; Arakawa, Yoshichika

doi:10.7883/yoken.jjid.2017.236

Cited by 8 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Owing to the limited numbers of the different pneumococcal serotypes in our data, it was difficult to perform any meaningful analysis to evaluate this relationship. It is however, of interest to note that the only full penicillin resistant isolate in this study was identified as serotype 19F, which has been previously associated with antibiotic resistance [ 50 ]. The prevalence of pneumococcal multidrug resistance observed among both adult and children SCD populations (>30%), concurs with the increasingly high pneumococcal multidrug resistance of 7.8–87%% observed in Ghana in the last decade [ 5 , 24 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Pneumococcal carriage among sickle cell disease patients in Accra, Ghana: Risk factors, serotypes and antibiotic resistance

et al. 2018

View full text Add to dashboard Cite

BackgroundPneumococcal carriage is the precursor for development of pneumococcal disease, and is also responsible for transmission of the organism from person-to-person. Individuals with Sickle Cell Disease (SCD) are more likely to develop invasive disease with S. pneumoniae compared to their healthy counterparts and the presentation of disease in the former is usually abrupt and severe. In Africa, little is known about the pneumococcus in relation to people with SCD Sickle Cell Disease (SCD). The aim of the study was to investigate the epidemiology of pneumococcal carriage among SCD patients including the carriage prevalence, risk factors, serotypes and antibiotic resistance.MethodThis was a cross sectional study involving 402 SCD patients recruited from Korle Bu Teaching Hospital and Princess Marie Louis Hospital in Accra from October 2016 to March 2017. The study subjects included 202 children of the age groups: ≤5 years (94), >5–9 years (75), ≥10–13 years (33) and 200 adults of the age groups: 14–20 years (46), 21–40 years (112), 41–60 years (25), ≤ 61 years (17). Nasopharyngeal (NP) swabs were collected from the study participants as well as epidemiological data on demographic, household and clinical features. The NP specimens were cultured for S. pneumoniae and the isolates were serotyped by latex agglutination. Antimicrobial susceptibility tests of the isolates were done by the disc diffusion test and E-test.ResultsPrevalence of S. pneumoniae carriage among children and adult SCD patients enrolled in the study were 79/202 (39.1%; 95% CI: 32.3 to 46.2) and 20/200 (10.0%; 95% CI: 6.2 to 15.0) respectively. Risk factors associated with pneumococcal carriage were age (OR = 1.137; 95% CI: 1.036–1.248; p = 0.007) and runny nose (OR = 5.371; 95% CI: 1.760–16.390; p = 0.003). Overall, twenty-six pneumococcal serotypes were isolated from the study participants and the predominant serotype was 6B (10.6%), followed by 23B (8.2%). Among the children, serotype coverage of the 13-valent Pneumococcal Conjugate Vaccine, which is currently used in Ghana was 32.4%. Prevalence of penicillin resistance among the pneumococcal isolates was 37.4% (37/99) and all the penicillin-resistant isolates exhibited intermediate penicillin resistance with the exception of one isolate that showed full resistance and was susceptible to ceftriaxone. Prevalence of resistance to the other antibiotics ranged from 2.5% (levofloxacin) to 85% (cotrimoxazole). Multidrug resistance occurred among 34.3% (34/99) of the pneumococcal isolates.ConclusionPneumococcal carriage was four-fold higher in SCD children than adults and was characterized by predominance of non-vaccine serotypes and considerable level of multidrug resistance, though penicillin, cefotaxime and levofloxacin resistance appeared to be very low.

show abstract

Section: Discussionmentioning

confidence: 99%

Pneumococcal carriage among sickle cell disease patients in Accra, Ghana: Risk factors, serotypes and antibiotic resistance

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Serotypes 14, 6A/B, and 19F were observed among highly resistant isolates with penicillin MICs ≥ 32. Dissemination of 19F isolates has increased in many parts of the world, and they have become resistant to penicillin (30)(31)(32). In this study, all 19F isolates were resistant to penicillin.…”

Section: Discussionmentioning

confidence: 63%

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Azimian

Khosrojerdi

Kebriaei

et al. 2021

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Streptococcus pneumonia is one of the common bacterial pathogens in pediatrics. In this study, we performed antimicrobial susceptibility testing, serotyping, and molecular typing of blood-isolated strains of pneumococci in Bojnurd. Objectives: In the current study, blood-isolated, penicillin-nonsusceptible Streptococcus pneumoniae strains were subjected to antimicrobial susceptibility testing and typing of capsular polysaccharides using the quelling reaction and PCR method, as well as genotyping using the Multi Locus Sequence Typing (MLST) method. Methods: In this study, 51 S. pneumonia strains were isolated from blood samples of children less than five-years-old in 2014 - 2018. Antibiogram was performed using the Kirby-Bauer method. All of the isolates were serotyped by the Quelling reaction and PCR. The MLST method was applied to determine the molecular types. Results: Our study revealed that the most common serotypes of blood-isolated pneumococci were 19A, 6A/B, 1, 23F, 19F, 14, 15B/C, and 15A, and the common serotypes in Penicillin-nonsusceptible pneumococci (PNSP) isolates were 19F, 19A, 23F, 14, and finally 15A, 6A/B, 1, and 15B/C. The MLST analysis of PNSP isolates revealed that three highly resistant isolates with MIC ≥ 16 belonged to Sweden15A-25-19A (ST63), Taiwan19F-14-1 (ST236), and Taiwan19F-14 (ST236) clones. Conclusions: Regarding the common serotypes in this study, it seems that PCV-13 is a suitable choice for vaccination in this area. We also observed a high prevalence of PNSP and MDR strains between 2014 and 2018. It seems that the Taiwan19F-14 clone and its related STs played an essential role in the diffusion of antibiotic-resistant S. pneumonia isolates in Bojnurd.

show abstract

Phenotypic and genotypic characteristics of non-invasive S. pneumoniae isolates recovered from PCV10-vaccinated children in Bulgaria

Alexandrova

Pencheva

Mitov

et al. 2022

Indian Journal of Medical Microbiology

View full text Add to dashboard Cite

Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible <i>Streptococcus pneumoniae</i> Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan

Cited by 8 publications

References 31 publications

Pneumococcal carriage among sickle cell disease patients in Accra, Ghana: Risk factors, serotypes and antibiotic resistance

Pneumococcal carriage among sickle cell disease patients in Accra, Ghana: Risk factors, serotypes and antibiotic resistance

Characterization of Blood-isolated, Penicillin-Nonsusceptible Streptococcus pneumoniae From Children Between 2014 and 2018 in Bojnurd, Iran

Phenotypic and genotypic characteristics of non-invasive S. pneumoniae isolates recovered from PCV10-vaccinated children in Bulgaria

Contact Info

Product

Resources

About