Preferential Expression of the Cell Adhesion Molecule CD44 in Papillary Thyroid Carcinoma

Figge, James; Rosario, A. D. Del; Gerasimov, G. A.; Dedov, Ivan I.; Bronstein, M. E.; Troshina, Katherine; Alexandrova, G. F.; Kallakury, Bhaskar; Bui, Hai X.; Bratslavsky, Gennady; Ross, Jeffrey S.

doi:10.1006/exmp.1994.1037

Cited by 41 publications

(28 citation statements)

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“…11,12,22 Our study showed intense staining for the CD44 cell adhesion molecule and cyclin D1 in FNA cytologic specimens of papillary carcinoma, confirming a previous report. 13 The results were confirmed on the corresponding resection specimens and appeared to be selective in that benign follicular cells and stromal elements were not reactive. The CD44 expression pattern was similar in both the lymph node metastasis and nonmetastasis group in FNA and resection specimens in this study.…”

Section: Discussionsupporting

confidence: 65%

“…11 In human breast cancer, a positive correlation has been found between the expression of CD44v6 and lymphatic metastasis. 12 Papillary thyroid carcinoma also expresses CD44 antigen, 13 as previously demonstrated in FNA specimens. 14 However, those studies were carried out on small numbers of patients.…”

Section: Objective: To Compare the Expression Pattern Of Cd44 And Cycmentioning

confidence: 81%

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Expression of CD44 and Cyclin D1 in Fine Needle Aspiration Cytology of Papillary Thyroid Carcinoma

Kim¹,

Cho²,

Rhee³

et al. 2002

Acta Cytologica

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Section: Discussionsupporting

confidence: 65%

Section: Objective: To Compare the Expression Pattern Of Cd44 And Cycmentioning

confidence: 81%

Expression of CD44 and Cyclin D1 in Fine Needle Aspiration Cytology of Papillary Thyroid Carcinoma

Kim¹,

Cho²,

Rhee³

et al. 2002

Acta Cytologica

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“…38,39 The heterogeneity of CD44 protein expression seems to arise from posttranslational modifications and alternative mRNA splicing.…”

Section: Discussionmentioning

confidence: 99%

“…13 -14 -38 - 39 The 85-to 95-kd CD44 macromolecule is known as the standard form, or CD44s, and has been associated with lymphocyte homing and recirculation and with invasion and metastasis of epithelial tumors. 15 CD44s and the variant isoforms produced by posttranslational splice modification are expressed on the cell membranes in a variety of normal epithelial cells, as well as in various malignant neoplasms.…”

Section: Discussionmentioning

confidence: 99%

CD44 Expression in Sinonasal Inverted Papillomas and Associated Squamous Cell Carcinoma

et al. 1998

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Increased expression of the cell adhesion molecule, CD44 standard form (CD44s), has been associated with papillary epithelial tumors, and decreased expression has been linked to tumor invasion and metastasis. Sinonasal inverted papillomas (SIPs) are the most common papillary tumors of the sinonasal tract. This study tests whether the development of squamous cell carcinoma (SCO in situ and invasive SCC in SIP is associated with altered expression of CD44s.Seventy-six specimens of SIP from 68 patients, 2 specimens of SIP with focal SCC in situ, and 10 specimens of invasive SCC arising in SIP were studied. Automated immunohistochemistry was performed for CD44s expression on paraffin-embedded tissue sections using mouse antihuman CD44 antibody.All 76 SIPs (100%) expressed CD44 (strong membranous staining, 83%; moderate staining, 12%; weak staining, 5%). TwoThe inverted papilloma is the most frequent benign mucosal neoplasm of the sinonasal tract.1-7 Sinonasal inverted papillomas (SIPs) are derived from the Schneiderian epithelium and occur most frequently during the fourth and fifth decades of life, with a male/female incidence ratio of 2:1.1 _ 6 Most commonly, SIP manifests as a unilateral nasal obstruction and features multiple mucosal sites of origin, reflecting a diffuse polypoid change of the nasal and paranasal sinus mucosa.6 Histologic features of SIP include squamous metaplasia of surface gland ducts and, frequently, branching gland ducts; stromal edema with infiltrates of lymphocytes, eosinophils, plasma cells, and m a c r o p h a g e s ; and n u m e r o u s macrophage-rich microcysts containing fragments of degenerated nuclear material.6 Although histologically benign, SIP features a substantial rate of recurrence after initial resection, which has varied from 33% to 74% in the published literature. [1][2][3][4][5][6] Squamous cell carcinoma (SCC) has been frequently associated with SIP since the first description by Hapman and Billroth in 1883/ Squamous cell carcinoma may be identified in the original excision of SIP or develop months or years after the first SIP excision, with roughly equal frequency. In published studies, the incidence of SCC associated with SIP has varied substantially. Woodson and c o w o r k e r s 8 reported an incidence of less than 2% of SCCs arising in SIP; Phillips and coworkers 9 reported a 7% incidence in 112 patients; and Bielamowicz et al 10 more recently reported a 17% cancer incidence in SIP.Cell adhesion molecules have been studied in a variety of papillary and nonpapillary epithelial neoplasms. CD44 is a polymorphic integral glycosylated cartilage link protein associated with cell matrix adhesion, lymphocyte activation and recirculation, and cell 309

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“…Expression of CD44 isoforms has been shown to be associated with metastasis and poor prognosis in colorectal cancer, gastrointestinal lymphoma, non-Hodgkin's lymphoma, thyroid, cervical and vulvar cancer (Jalkanen et al, 1991;Joensuu et al, 1993a;Wielenga et al, 1993;Figge et al, 1994;Kainz et al, 1995;Tempfer et al, 1996).…”

mentioning

confidence: 99%

The prognostic value of CD44 isoform expression in endometrial cancer

Tempfer

Haeusler²,

Kaider³

et al. 1998

Br J Cancer

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Preferential Expression of the Cell Adhesion Molecule CD44 in Papillary Thyroid Carcinoma

Cited by 41 publications

References 0 publications

Expression of CD44 and Cyclin D1 in Fine Needle Aspiration Cytology of Papillary Thyroid Carcinoma

Expression of CD44 and Cyclin D1 in Fine Needle Aspiration Cytology of Papillary Thyroid Carcinoma

CD44 Expression in Sinonasal Inverted Papillomas and Associated Squamous Cell Carcinoma

The prognostic value of CD44 isoform expression in endometrial cancer

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