Preferential hyperacuity perimeter in assessing responsiveness to ranibizumab therapy for exudative age-related macular degeneration

Querques, Giuseppe; Berboucha, Elya; Leveziel, Nicolas; Pece, Alfredo; Souied, Eric H.

doi:10.1136/bjo.2010.190942

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…Measuring changes in metamorphopsia has been shown to be an effective method of detecting the condition 7,8 and of monitoring response to treatment. 14,15 D-charts offer some advantages over existing methods of measuring metamorphopsia. M-charts use smaller elements in the targets, which makes them difficult to use for patients with vision less than 0.6 logMAR.…”

Section: Discussionmentioning

confidence: 99%

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McGowan

Yorston

Strang

et al. 2016

Retina

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Section: Discussionmentioning

confidence: 99%

D-Chart

McGowan

Yorston

Strang

et al. 2016

Retina

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“…It has an 85% sensitivity rate and 85% specificity [7,8,9,10,11,12,13,14,15,16,17,18]. It is significantly more sensitive than the Amsler grid for early detection of CNV and shows changes after anti-VEGF therapy.…”

Section: Figmentioning

confidence: 99%

Use of Home Device for Early Detection of Neovascular Age-Related Macular Degeneration

Loewenstein¹

2012

Ophthalmic Res

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Early treatment for choroidal neovascularization (CNV) is an important part of preserving visual function for patients with age-related macular degeneration. Preferential hyperacuity perimetry (PHP) provides high accuracy, sensitivity and specificity for detecting changes in lesions in diagnostic and treatment stages. The ForeseeHome is a PHP device designed for home use by patients. Regular use alerts retina specialists and patients of detected changes and allows patients to come in for visits when CNV begins or recurs. To maximize the benefit of recent breakthroughs in CNV treatment, patients should be better monitored with the ForeseeHome to detect new CNV while their vision is still good, and to promptly manage recurrence after treatment.

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“…This mechanism allows for the creation of a quantified visual field map of the metamorphopsia for each eye and longitudinal detections of changes in such maps as well as deviation from the normal population [19]. For severity measurements we used the ‘PHP test score' [13]. This score is normalized to values of p between 0 and 1 (which indicates the probability of the tested eyes to have such a visual field defect) and has been previously validated as a classifier to discriminate between patients with intermediate non-neovascular AMD and patients with neovascular AMD.…”

Section: Methodsmentioning

confidence: 99%

“…However, these charts do not yield quantitative data. Preferential hyperacuity perimetry (PHP; ForeseeHome; Notal Vision, Tel Aviv, Israel) has recently gained popularity as a device for objectively monitoring visual distortion in age-related macular degeneration (AMD) [13,14]. …”

Section: Introductionmentioning

confidence: 99%

Short-Term Retinal Sensitivity and Metamorphopsia Changes following Half-Fluence Photodynamic Therapy in Central Serous Chorioretinopathy

et al. 2016

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Purpose: The aim of this study was to investigate the short-term retinal sensitivity and metamorphopsia changes after half-fluence photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC). Methods: Patients with acute CSC and evidence of angiographic leakage and subretinal fluid on optical coherence tomography (OCT) were enrolled. Before, and 1 week (W-1) and 2 months (M-2) after PDT, all patients underwent best-corrected visual acuity, enhanced depth imaging OCT, microperimetry (MP) and preferential hyperacuity perimetry (PHP). We considered ‘affected' the Early Treatment of Diabetic Retinopathy Study (ETDRS) sectors showing a mean retinal thickness greater than 350 μm on the baseline OCT thickness map. MP retinal sensitivity, PHP ‘score' and retinal thickness were measured in each ETDRS ‘affected sector'. Functional correlation between MP and PHP was also investigated. Results: Twelve eyes of 12 patients were included. MP and PHP correlated with each other at baseline (p = 0.04) but not at W-1 (p = 0.12) and M-2 (p = 0.05). Mean MP retinal sensitivity slightly improved from 12.9 ± 5.0 dB at baseline to 14.5 ± 4.7 dB at M-2 (p = 0.2). The PHP score changed from 0.33 at baseline to 0.32 at M-2 (p = 0.3). In the ETDRS ‘affected sectors', MP retinal sensitivity improved significantly from 12.9 ± 5.0 dB at baseline to 14.5 ± 4.7 dB at M-2 (p = 0.03), whereas the PHP score did not show significant changes over time. Conclusion: Half-fluence PDT achieved short-term improvement in the sensitivity of the retinal ‘affected sectors' but did not influence metamorphopsia as measured on PHP in patients with acute CSC.

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Preferential hyperacuity perimeter in assessing responsiveness to ranibizumab therapy for exudative age-related macular degeneration

Cited by 12 publications

References 13 publications

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Use of Home Device for Early Detection of Neovascular Age-Related Macular Degeneration

Short-Term Retinal Sensitivity and Metamorphopsia Changes following Half-Fluence Photodynamic Therapy in Central Serous Chorioretinopathy

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