Prefronto&amp;ndash;cerebellar transcranial direct current stimulation improves visuospatial memory, executive functions, and neurological soft signs in&amp;nbsp;patients with euthymic bipolar disorder

Minichino, Amedeo; Bersani, Francesco Saverio; Bernabei, Laura; Spagnoli, Francesco; Vergnani, Lucilla; Corrado, Alessandra; Taddei, Ines; Biondi, Massimo; Chiaie, R. Delle

doi:10.2147/ndt.s79108

Cited by 27 publications

(18 citation statements)

References 37 publications

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“…In general, anodal stimulation is believed to enhance motor and cognitive functions, whereas cathodal stimulation typically inhibits functioning. However, in several studies, cathodal stimulation was associated with a neurobehavioral effect in agreement with an enhanced function of the cerebellar cortex (Galea et al, 2011 ; Ferrucci et al, 2012 ; Pope and Miall, 2012 ; Shah et al, 2013 ; Bersani et al, 2015 ; Bocci et al, 2015 ; Bradnam et al, 2015 ; Minichino et al, 2015 ; Panouillères et al, 2015b ). On the other hand some studies have shown that anodal stimulation may impair cerebellar function (Ferrucci et al, 2008 ; Foerster et al, 2013 ; Dutta et al, 2014 ; Macher et al, 2014 ; Bocci et al, 2015 ; Doeltgen et al, 2015 ; Panouillères et al, 2015b ; Chothia et al, 2016 ).…”

Section: Technical Issuesmentioning

confidence: 67%

“…The few studies based on multiple sessions are clinical studies. Most of these studies used multiple 5-day interventions (1–4 weeks) and administered one (Gironell et al, 2014 ; Ho et al, 2014 ; Minichino et al, 2015 ; Ferrucci et al, 2016 ) or two stimulation sessions a day (Bation et al, 2016 ). Bradnam et al ( 2014 ), on the other hand, stimulated twice a week for a period of 12 weeks.…”

Section: Technical Issuesmentioning

confidence: 99%

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tDCS of the Cerebellum: Where Do We Stand in 2016? Technical Issues and Critical Review of the Literature

Dun

Bodranghien

Mariën

et al. 2016

Front. Hum. Neurosci.

100

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Transcranial Direct Current Stimulation (tDCS) is an up-and-coming electrical neurostimulation technique increasingly used both in healthy subjects and in selected groups of patients. Due to the high density of neurons in the cerebellum, its peculiar anatomical organization with the cortex lying superficially below the skull and its diffuse connections with motor and associative areas of the cerebrum, the cerebellum is becoming a major target for neuromodulation of the cerebellocerebral networks. We discuss the recent studies based on cerebellar tDCS with a focus on the numerous technical and open issues which remain to be solved. Our current knowledge of the physiological impacts of tDCS on cerebellar circuitry is criticized. We provide a comparison with transcranial Alternating Current Stimulation (tACS), another promising transcranial electrical neurostimulation technique. Although both tDCS and tACS are becoming established techniques to modulate the cerebellocerebral networks, it is surprising that their impacts on cerebellar disorders remains unclear. A major reason is that the literature lacks large trials with a double-blind, sham-controlled, and cross-over experimental design in cerebellar patients.

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Section: Technical Issuesmentioning

confidence: 67%

Section: Technical Issuesmentioning

confidence: 99%

tDCS of the Cerebellum: Where Do We Stand in 2016? Technical Issues and Critical Review of the Literature

Dun

Bodranghien

Mariën

et al. 2016

Front. Hum. Neurosci.

100

View full text Add to dashboard Cite

show abstract

“…In this regard, bilateral M1 combined with PFC stimulation has been successfully applied (Vines et al, 2008; Mordillo-Mateos et al, 2012; Leite et al, 2013; Naros et al, 2016). However, the characterization of the effects associated to concomitant stimulation of different brain regions is nearly absent in the literature (Kaminski et al, 2013; Minichino et al, 2015) due to the low focality inherent to the technique and the inability from traditional tDCS devices to simultaneously control multiple stimulation electrodes. Indeed, there has been some progression in recent years.…”

Section: Considerations On Motor Learning Modulation and New Perspectmentioning

confidence: 99%

Modulating Motor Learning through Transcranial Direct-Current Stimulation: An Integrative View

2016

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Motor learning consists of the ability to improve motor actions through practice playing a major role in the acquisition of skills required for high-performance sports or motor function recovery after brain lesions. During the last decades, it has been reported that transcranial direct-current stimulation (tDCS), consisting in applying weak direct current through the scalp, is able of inducing polarity-specific changes in the excitability of cortical neurons. This low-cost, painless and well-tolerated portable technique has found a wide-spread use in the motor learning domain where it has been successfully applied to enhance motor learning in healthy individuals and for motor recovery after brain lesion as well as in pathological states associated to motor deficits. The main objective of this mini-review is to offer an integrative view about the potential use of tDCS for human motor learning modulation. Furthermore, we introduce the basic mechanisms underlying immediate and long-term effects associated to tDCS along with important considerations about its limitations and progression in recent years.

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“…A recent literature review cites evidence of the physiological role of the cerebellum in maintaining mood as well as its implication in the pathophysiology of bipolar disorder and major depressive disorder. Minichino et al 30 suggested the cerebellum has roles in cognition, mood and behavior 31,32,33 . In their study, they pointed to the role of the cerebellum in modulating emotional processing, providing strong evidence from clinical and electrophysiological studies to support their view.…”

Section: Discussionmentioning

confidence: 99%

Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes

Iannone

Allam

Brasil‐Neto

2019

Arq. Neuro-Psiquiatr.

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Background: Transcranial direct current stimulation (tDCS) has been investigated in movement disorders, making it a therapeutic alternative in clinical settings. However, there is still no consensus on the most appropriate treatment protocols in most cases, and the presence of deep brain stimulation (DBS) electrodes has been regarded as a contraindication to the procedure. We recently studied the effects of cerebellar tDCS on a female patient already undergoing subthalamic nucleus deep brain stimulation (STN-DBS) for generalized dystonia. She also presented with chronic pain and depression. With STN-DBS, there was improvement of dystonia, and botulinum toxin significantly reduced pain. However, depressive symptoms were worse after STN-DBS surgery. Methods: Neuromodulation with 2 mA anodal cerebellar tDCS was initiated, targeting both hemispheres in each daily 30 minute session: 15 minutes of left cerebellar stimulation followed by 15 minutes of right cerebellar stimulation. The DBS electrodes were in place and functional, but the current was turned off during tDCS. Results: Although our goal was to improve dystonic movements, after 10 tDCS sessions there was also improvement in mood with normalization of Beck Depression Inventory scores. There were no complications in spite of the implanted STN-DBS leads. Conclusion: Our results indicate that tDCS is safe in patients with DBS electrodes and may be an effective add-on neuromodulatory tool in the treatment of potential DBS partial efficacy in patients with movement disorders.

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Prefronto–cerebellar transcranial direct current stimulation improves visuospatial memory, executive functions, and neurological soft signs in patients with euthymic bipolar disorder

Cited by 27 publications

References 37 publications

tDCS of the Cerebellum: Where Do We Stand in 2016? Technical Issues and Critical Review of the Literature

tDCS of the Cerebellum: Where Do We Stand in 2016? Technical Issues and Critical Review of the Literature

Modulating Motor Learning through Transcranial Direct-Current Stimulation: An Integrative View

Safety of transcranial direct current stimulation in a patient with deep brain stimulation electrodes

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