Pregnancy and Fertility Following Bariatric Surgery: A Systematic Review

Maggard, Melinda A.; Yermilov, Irina; Li, Z.; Maglione, Marco; Newberry, Sydne J; Suttorp, Marika J; Hilton, Lara; Santry, Heena P.; Morton, John M.; Livingston, Edward H.; Shekelle, PG

doi:10.1097/01.aoa.0000362056.35613.8a

Cited by 87 publications

(137 citation statements)

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“…Reproductive age women are also of particular interest because of the link among maternal obesity, gestational diabetes, adverse perinatal outcomes, and transgenerational transmission of a metabolic phenotype to the offspring. Despite previous concerns about the potentially deleterious effect of bariatric surgery on maternal nutrition, bariatric surgery has been demonstrated to improve maternal outcomes and likely improves neonatal outcomes [11,12]. Although women disproportionately undergo bariatric surgery, the rodent models investigating the mechanisms of bariatric surgery have been limited to males.…”

Section: Discussionmentioning

confidence: 99%

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

et al. 2013

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Restriction of food intake leads to immunologic and histomorphological changes in rats demonstrated by Moriyama. This study is planned to show how sleeve gastrectomy restricts food intake and its effects on biochemical liver function, immunologic and hematologic laboratory parameters, and histomorphological changes in rats. We used sleeve gastrectomy model on seven young adult female rats and compared study group with sham and control groups. Food consumption of rats was measured. All rats were sacrificed on the 50th day, and blood and tissue samples were collected. There was a significant low food intake in sleeve gastrectomy group (p=0.013). No differences were observed on hematologic, biochemical, and immunologic laboratory parameters between groups. Toxicity parameters in liver samples such as cytoplasmic atrophy, single-cell hepatocellular necrosis, and necrotic eosinophilic cells were significantly high in sleeve gastrectomy group (p=0.005). Histomorphological examination of the spleen and kidneys revealed significant changes in sleeve gastrectomy and sham groups compared with controls (p=0.004 and p=0.018, respectively). Although sleeve gastrectomy does not lead to alteration in hematologic, biochemical, and immunologic laboratory parameters, it causes decreased food consumption, which results in toxicological histomorphological changes in rat liver as well as some changes in kidney and spleen samples.

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Section: Discussionmentioning

confidence: 99%

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

et al. 2013

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“…There are several studies that have evaluated obstetric outcome after bariatric surgery (8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Bariatric surgery in a national cohort of women: sociodemographics and obstetric outcomes

Josefsson

Blomberg

Bladh

et al. 2011

American Journal of Obstetrics and Gynecology

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Word countAbstract: 144 words women who had undergone bariatric surgery constituted the index group. Results:The index women more often have parents with lower sociodemographic status and are more often born LGA. The women surgically treated before their first child had a shorter gestational length, their children had lower birth weight and were more often born SGA compared to the children born to the reference mothers. Women whose child was born prior to their bariatric surgery more often had a cesarean section, and their children were more often LGA. Conclusion:Preconception bariatric surgery in obese women may be associated with improved obstetrical outcomes.

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“…In the USA, the incidence of bariatric surgery has increased by 800% from 1998 to 2005, with more than 50 000 women aged 18-45 currently having bariatric surgery per annum (49) . The rate of bariatric surgery is similarly increasing in other developed countries (50) .…”

Section: Bariatric/surgical Interventionsmentioning

confidence: 99%

“…A systematic review by Maggard et al (49) evaluated the effect of bariatric surgery on pregnancy outcomes. To date, there are no randomised controlled trials comparing pregnancy outcome after bariatric surgery.…”

Section: Bariatric/surgical Interventionsmentioning

confidence: 99%

Improving pregnancy outcome in obese women

Denison

Chiswick

2011

Proc. Nutr. Soc.

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The global pandemic of maternal obesity presents a major challenge for healthcare providers, and has significant short- and long-term implications for both maternal and fetal health. Currently, the evidence-base underpinning many of the interventions either currently in use or recommended to improve pregnancy outcome in obese women is limited. The nature and timing of these interventions vary widely, ranging from simple advice to more intensive dietary and exercise programmes, cognitive behavioural therapy and drug trials. In addition, a growing number of very severely obese women now enter pregnancy having had surgical interventions. Although surgical interventions such as gastric bypass or banding may be associated with improved pregnancy outcomes, these women have particular nutritional requirements, which need to be addressed to optimise pregnancy outcome. Until the outcomes of ongoing current trials are reported and provide a firm evidence base on which to base future intervention strategies and guide evidence based care for obese pregnant women, pregnancy outcome is best optimised by high-risk antenatal care delivered by healthcare providers who are experienced in supporting these high-risk women.

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Pregnancy and Fertility Following Bariatric Surgery: A Systematic Review

Cited by 87 publications

References 0 publications

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

Bariatric surgery in a national cohort of women: sociodemographics and obstetric outcomes

Improving pregnancy outcome in obese women

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