Pregnancy in Chronic Active Hepatitis

Increased risk of preterm birth in women with autoimmune hepatitis – a nationwide cohort study

“…Previous studies of mothers with AIH have shown increased risk of preterm deliveries . Our study confirms these findings.…”

“…Many of these women reduced their medication during pregnancy and abstained from breastfeeding . Previous studies on pregnancy outcome in women with AIH have reported increased risks of pregnancy loss, preterm delivery and pre‐eclampsia, and a correlation with maternal SLA/LA antibodies has been suggested . These findings are somewhat conflicting because of the small sample size and limitations in the study design.…”

Pregnancy and birth outcomes in a Danish nationwide cohort of women with autoimmune hepatitis and matched population controls

“…We confirmed findings from other studies showing an increased risk of preterm birth in women with autoimmune hepatitis . In contrast with these studies, we evaluated first‐time births specifically, and thus our results were not affected by any excess risk of preterm birth in women who had previously given preterm birth .…”

“…Most studies were small, some included births occurring both before and after autoimmune hepatitis diagnosis, and all included twin births or successive births. An excess risk of miscarriage and a greater risk of adverse birth outcomes were reported in both the older and the more recent studies . The studies indicated that immunosuppressive regimens during pregnancy and cirrhosis were not associated with adverse birth outcomes .…”

“…Our knowledge of birth outcomes in women with autoimmune hepatitis is based on studies with methodological limitations . Most studies were small, some included births occurring both before and after autoimmune hepatitis diagnosis, and all included twin births or successive births.…”