Pregnancy of unknown location

Boyraz, Gökhan; Bozdağ, Gürkan

doi:10.5152/jtgga.2013.74317

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…During this surveillance period, no medical or surgical intervention is taken until a conclusive diagnosis of ectopic pregnancy is reached, and the non-viability of the embryo is concluded [31]. Thus, the clinicians' objectives are to: (1) Diagnose ectopic pregnancy as early as possible to avoid health risks, (2) Ensure that this early diagnosis is correct, to avoid ending a viable pregnancy erroneously [32]. Delayed diagnosis of EP is the most common life-threatening emergency in early pregnancy [31].…”

Section: Case Studiesmentioning

confidence: 99%

Reproducible Bioconductor Workflows Using Browser-based Interactive Notebooks and Containers

Almugbel

Hung

et al. 2017

Preprint

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Objective:Bioinformatics publications typically include complex software workflows that are difficult to describe in a manuscript. We describe and demonstrate the use of interactive software notebooks to document and distribute bioinformatics research. We provide a user-friendly tool, BiocImageBuilder, to allow users to easily distribute their bioinformatics protocols through interactive notebooks uploaded to either a GitHub repository or a private server. Materials and methods:We present three different interactive Jupyter notebooks using R and Bioconductor workflows toinfer differential gene expression, analyze cross-platform datasets and process RNA-seq data.These interactive notebooks are available on GitHub. The analytical results can be viewed in a browser. Most importantly, the software contents can be executed and modified. This is accomplished using Binder, which runs the notebook inside software containers, thus avoiding the need for installation of any software and ensuring reproducibility. All the notebooks were produced using custom files generated by BiocImageBuilder. Results:BiocImageBuilder facilitates the publication of workflows with a point-and-click user interface.We demonstrate that interactive notebooks can be used to disseminate a wide range of bioinformatics analyses. The use of software containers to mirror the original software environment ensures reproducibility of results. Parameters and code can be dynamically modified, allowing for robust verification of published results and encouraging rapid adoption of new methods.

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Section: Case Studiesmentioning

confidence: 99%

Reproducible Bioconductor Workflows Using Browser-based Interactive Notebooks and Containers

Almugbel

Hung

et al. 2017

Preprint

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“…The estimated maternal mortality rate in 2009 in the United Kingdom was around 3.4% [2]. The term "pregnancy of unknown location" is used when the biochemical test for pregnancy in the blood is positive, but the gestational sac is not seen on ultrasound [3]. This happens in about 8 -31% of women, which largely depends on the experience of the physician making the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Conservative approach in the management of ectopic pregnancy

Nišević¹,

Vuković

Milatovic

et al. 2021

Med pregl

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Introduction. Ectopic pregnancy is defined as the implantation of a fertilized ovum outside the uterine cavity and it is one of the leading causes of maternal morbidity and mortality. Localization and risk factors. The most common localization of ectopic pregnancy is within the fallopian tube, while other localizations include abdominal organs, ovaries, scars after previous cesarean sections, and cervix. Risk factors for ectopic pregnancy include previous fallopian tube injuries, infertility including multiple embryo transfers, use of contraceptives, smoking, older age, prior history of ectopic pregnancy, intentional abortions. Diagnostic procedures. Measurement of serum beta-human chorionic gonadotropin levels along with certain ultrasonography signs, i.e. extrauterine gestational sac, with a present yolk sac and/or embryo, with or without a cardiac activity, have the highest degree of reliability in making the diagnosis, whereas uncertain signs, such as ?blob? and ?bagel? signs, also have a high positive predictive value. Therapeutic modalities. Ectopic pregnancy can be treated by surgical, medical or expectant management. Expectant and medical management are reserved for hemodynamically stable patients who are adequately informed and where monitoring and control are possible. Conservative treatment. Before the initiation of treatment with methotrexate, it is necessary to rule out a vital intrauterine pregnancy, and consider the contraindications for methotrexate therapy, based on detailed medical history and laboratory tests. The Clinic of Obstetrics and Gynecology of the Clinical Center of Vojvodina uses a two-dose protocol by which methotrexate is administered intramuscularly and which has proven to be highly successful with few side effects. Surgical treatment modalities. Candidates for emergency laparoscopy or laparotomy are women who are hemodynamically unstable and who should not receive methotrexate. Conclusion. In properly selected patients, the success rate of methotrexate therapy is around 93%.

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“…Therefore management of PUL seems to be highly crucial in obstetrics clinics. [5] Ectopic pregnancy remains a leading cause of direct maternal death whose incidence has progressively increased during the past years. [6] This study was intended to determine the prevalence of pregnancy of unknown location (PUL) and its outcome.…”

Section: Introductionmentioning

confidence: 99%