Pregnancy Outcome in Patients with Common Variable Immunodeficiency

Králíčková, Pavlína; Kuřecová, Barbora; Andrýs, Ctirad; Krčmová, Irena; Jílek, Dalibor; Vlková, Marcela

doi:10.1007/s10875-015-0188-7

Cited by 14 publications

(5 citation statements)

References 23 publications

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“…Поэтому введение препаратов иммуноглобулинов в дозах, обычно назначаемых небеременным женщинам, не поддерживает оптимальный уровень материнского IgG в сыворотке и приводит к снижению эффективности ВВИГ у беременных женщин. И IgG, и IgA на протяжении всей беременности снижаются до уровня 60-70 % (на 37-41 неделе беременности) [9] от исходной концентрации на ранних сроках беременности. Это указывает на необходимость увеличения дозы IgG во время большинства беременностей для поддержания стабильного минимального уровня IgG у матери и достаточного поступления IgG к плоду [10].…”

Section: Discussionunclassified

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Features of primary immunodeficiency during pregnancy: clinical case

Negodnova,

Iskandyarova,

Krasnoglazova

et al. 2024

Immunopathol Allergol Infectol

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Primary immunodeficiencies (PIDs) are a group of hereditary diseases in which individual parts of the immune system do not function properly. Most often, patients first present with clinical symptoms in childhood, but some defects may not be recognized until later in life, such as common variable immune deficiency (CVID). The desire to have a child in people suffering from PID may be accompanied by a fear of complications in the mother and the birth of a child with immunodeficiency. Management of pregnancy in women with PID is recommended with the joint participation of an obstetrician-gynecologist and an allergist-immunologist. We report a favorable outcome in a patient with CVID who continued to receive intravenous immunoglobulin replacement therapy during pregnancy.

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Section: Discussionunclassified

“…9 /л, СОЭ 28 мм/ч. Общий анализ мочи от 12.05.23: жёлтая, прозрачная, кислая, белок 30 мг/л, эпителий 5-6 в поле зрения, лейкоциты 3-4 в поле зрения, эритроциты 2-3 в поле зрения.…”

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Features of primary immunodeficiency during pregnancy: clinical case

Negodnova,

Iskandyarova,

Krasnoglazova

et al. 2024

Immunopathol Allergol Infectol

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“…In mice, it was shown that the lack of mature B cells is associated with reduced litter size, decreased size of the embryos, and higher susceptibility to prenatal infections (Busse et al, 2019). In women with common variable immunodeficiency, a condition associated with reduced frequencies of switched memory B cells in peripheral blood (Bright et al, 2013), an elevated risk for preterm birth or other pregnancy complications, such as PE, stillbirth, or vaginal bleeding, was observed (Kralickova et al, 2015). Recurrent miscarriage (Carbone et al, 2016;Ota et al, 2014) and PE (Zeng et al, 2013) were linked to alterations in the induction of B cell memory.…”

Section: Discussionmentioning

confidence: 99%

Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus

et al. 2020

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“…Women with common variable immune deficiency (CVID) had lower fertility and the same rate of pregnancy loss as the general population in the USA [110]. However, another study showed no differences between the CVID and non-CVID populations [111].…”

Section: Infections and Immune Dysregulationmentioning

confidence: 99%

Do endometrial immune changes with age prior to menopause compromise fertility in women?

2022

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Menopause signals the end of the reproductive period in women. However, fertility and fecundity decrease with increasing age prior to menopause demonstrating that changes in the premenopausal female reproductive tract (FRT) are already occurring that negatively impact reproductive success. The effects of age on the endometrium are poorly understood, in contrast to the ovary where changes occur with increasing age that negatively affect successful reproduction. The endometrial immune system is essential for generating a receptive endometrium, but the link between the immune and reproductive systems in the endometrium in the years prior to menopause has not been well-defined. Since the endometrial immune system is tightly regulated to maximize reproductive success and pathogen protection, changes in immune function with increasing premenopausal age have the potential to impact reproduction.

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Pregnancy Outcome in Patients with Common Variable Immunodeficiency

Abstract: Fertility in CVID patients is not decreased, and their pregnancies could be considered more risky compared with those of the general population.

Cited by 14 publications

References 23 publications

Features of primary immunodeficiency during pregnancy: clinical case

Features of primary immunodeficiency during pregnancy: clinical case

Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus

Do endometrial immune changes with age prior to menopause compromise fertility in women?

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