Pregnancy termination in dogs with non‐hormonal compounds: evaluation of selected derivatives

Galliani, G.; Omodei‐Saléa, A.

doi:10.1111/j.1748-5827.1982.tb01668.x

Cited by 10 publications

(8 citation statements)

References 2 publications

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“…Our studies of conceptus elimination indicate that pregnancy arrest induced by DL 7 17-IT is not accompanied by uterine disturbances. This agrees with what was repeatedly demonstrated for DL 7 17-IT analogues by direct (uterine histology) or indirect (maintenance of fertility) means (Galliani & Lerner, 1976;Galliani et a/., 1981. For D L 717-IT, the above assertion is reinforced by the fact that no impairment of later reproductive performance was seen (Galliani.…”

Section: Discussionsupporting

confidence: 92%

“…For several years, we have been studying a new class of non-hormonal pregnancy-terminating compounds that arrest pregnancy in all the animal species tested. including the bitch (Lerner et al, 1975;Galliani & Lerner. 1976;Galliani ef al., 1980, 198 1).…”

Section: Introductionmentioning

confidence: 99%

“…the objective was to find a compound that is highly effective when given in a single parenteral dose at any time during a broad period of gestation. Among several analogues studied in the dog (Galliani & Lerner. 1976;Galliani er al., 1982: Galliani & Omodei-Sale, 1982.…”

Section: Introductionmentioning

confidence: 99%

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DL 717‐IT: a non‐hormonal agent for the control of fertility in the bitch

Galliani¹,

Caramel²,

Assandri³

1984

J of Small Animal Practice

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The development of a new class of non‐hormonal contragestational agents provided a derivative, 2‐(4‐chlorophenyl)‐striazole|5,1‐alisoquinoline (DL 717‐IT or L 12717), with the qualities needed for application in the veterinary field as a post‐coital pregnancy‐terminating agent. Single intramuscular injections of this compound arrest pregnancy over a wide period of gestation in the bitch. A dose of 2.5 mg/kg was found to be very well tolerated and highly effective (100 per cent) when administered between the day of mating and the 15th day of pregnancy. The desired effect was not accompanied by uterine disorders or other unwanted effects. This non‐hormonal agent appears to have several real advantages over the only other drugs (oestrogens) available in veterinary practice for the termination of unwanted pregnancies in bitches.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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DL 717‐IT: a non‐hormonal agent for the control of fertility in the bitch

Galliani¹,

Caramel²,

Assandri³

1984

J of Small Animal Practice

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“…2-Phenyl-triazole[S, 1 -alisoindoles and the corresponding isoquinolines are a unique class of non-hormonal anti-fertility agents with post-implantation activity. When administered subcutaneously or intramuscularly in single and multiple doses, these compounds terminate pregnancy in several species, including the bitch (Galliani & Lerner, 1976). Their activity was found to be dependent on the administered dose and the time of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…Their activity was found to be dependent on the administered dose and the time of pregnancy. They are maximally effective when given immediately after implantation of fertilized ova, that is on day 4 of gestation in the hamster, day 7 in the rat and day 20 in the bitch (Galliani & Lerner, 1976, 1976aGalliani et al, 1977Galliani et al, , 1980Galliani et al, , 1981.…”

Section: Introductionmentioning

confidence: 99%